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An enhanced requirement for nutrients is a hallmark property of cancer cells. Here, we optimized an in vivo genetic screening strategy in acute myeloid...

While germline and somatic mutations in the gene PTPN11, encoding a phosphatase which regulates the RAS signaling pathway, are well characterized in children with...

Acalabrutinib, venetoclax, and obinutuzumab is a highly active and well tolerated frontline therapy for chronic lymphocytic leukaemia. Although the primary endpoint of this study...

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The bone marrow aspirate is arguably the most straightforward aspect of the bone marrow workup. A syringe with applied negative pressure gently removes approximately 5...

The marrow aspirate clot particle is one of the 4 specimens assessed by hematopathologists in a routine marrow examination.Since the marrow is abundantly deep...

CAMBRIDGE, Mass., September 15, 2021–Magenta Therapeutics, Inc. (Nasdaq: MGTA), a clinical-stage biotechnology company developing novel medicines to bring the curative power of stem cell...

CRISPR-Cas9-based genetic screens have successfully identified cell type-dependent liabilities in cancer, including acute myeloid leukemia (AML), a devastating hematologic malignancy with poor overall survival....

During the 47th Annual Meeting of the European Society for Blood and Marrow Transplantation (EBMT), the AML Hub spoke to Claudia Núñez-Torrón, Hospital Universitario...

Key Points. PTPN11 mutations are recurrent alterations in patients with AML and are an independent prognostic factor for poor survival.The deleterious effect...

The addition of venetoclax to fludarabine, cytarabine, idarubicin and G-CSF resulted in high complete response rates and enables a high consolidative allogeneic transplantation rate...