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Mashup Score: 3Could leptin substitution therapy potentially terminate entrapment in anorexia nervosa? - Nature Reviews Endocrinology - 9 month(s) ago
Case studies of patients with anorexia nervosa revealed psychological improvements upon treatment with recombinant human leptin, including an alleviation of the entrapment in this eating disorder. Hypoleptinaemia induced by loss of adipose tissue mass might trigger psychological changes observed in starvation. Accordingly, leptin analogues might prove beneficial for treatment of anorexia nervosa.
Source: NatureCategories: Endocrinology, Latest HeadlinesTweet
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Mashup Score: 24High-Dose Leptin Reversed Severe Genetic Obesity in Two Patients - 9 month(s) ago
Metreleptin doses several times higher than recommended brought weight down to near normal
Source: www.medpagetoday.comCategories: Expert Picks, Latest HeadlinesTweet
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Mashup Score: 2Could leptin substitution therapy potentially terminate entrapment in anorexia nervosa? - Nature Reviews Endocrinology - 10 month(s) ago
Case studies of patients with anorexia nervosa revealed psychological improvements upon treatment with recombinant human leptin, including an alleviation of the entrapment in this eating disorder. Hypoleptinaemia induced by loss of adipose tissue mass might trigger psychological changes observed in starvation. Accordingly, leptin analogues might prove beneficial for treatment of anorexia nervosa.
Source: NatureCategories: Endocrinology, Latest HeadlinesTweet
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Mashup Score: 12
An international team of doctors and medical scientists has found two rare leptin variants in two children. Both variants led to hyperphagia and obesity. In their study, reported in The New England Journal of Medicine, the group found mutations in genes responsible for leptin production and explored how they impacted eating behavior in the patients.
Source: medicalxpress.comCategories: General Medicine News, Latest HeadlinesTweet
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Mashup Score: 1The History of Obesity Research - 1 year(s) ago
Perhaps the most unexpected development in pediatric endocrinology in the past 50 years has been the recognition of obesity as an endocrine/metabolic disorder rather than a life choice or moral failing. The history of obesity research is disjointed, having followed two separate paths in the 20th century, based on two independent yet overlapping par
Source: www.karger.comCategories: Healthcare Professionals, Latest HeadlinesTweet
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Mashup Score: 1The rheumatoid arthritis drug auranofin lowers leptin levels and exerts antidiabetic effects in obese mice - 1 year(s) ago
The FDA-approved rheumatoid arthritis drug auranofin accumulates in white adipose tissue, improves insulin sensitivity, and normalizes fatty-liver disease in obesity. Beta-adrenergic receptor regulation of leptin secretion generates metabolic benefits superior to anti-inflammatory effects. Consequently, studies of auranofin reinforce that partial leptin reduction represents a relevant method for…
Source: Cell MetabolismCategories: Healthcare Professionals, Latest HeadlinesTweet
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Mashup Score: 0Increase in Leptin Levels in Preeclampsia Prompts Cardiovascular Cascade That Puts Mother and Baby at Risk - 2 year(s) ago
June 30, 2022 — Before a baby is ever born, critical supply chain problems with nutrition and oxygen can result in premature birth or even death and increase the child and mother’s lifelong risk of cardiovascular disease. Scientists have found that a midgestation increase in the hormone leptin, which most of us associate with appetite suppression, produces problematic blood vessel dysfunction…
Source: DAICCategories: Cardiologists, Latest HeadlinesTweet
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Mashup Score: 4Trends in the Incidence of New‐Onset Hypertensive Disorders of Pregnancy Among Rural and Urban Areas in the United States, 2007 to 2019 - 2 year(s) ago
Background Hypertensive disorders of pregnancy are growing public health problems that contribute to maternal morbidity, mortality, and future risk of cardiovascular disease. Given established rura…
Categories: General Medicine News, Latest HeadlinesTweet
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Mashup Score: 1
To characterize the contributions of the loss of energy-expending tissues and metabolic adaptations to the reduction in resting metabolic rate (RMR) following weight loss. A secondary analysis was conducted on data from the Comprehensive Assessment of Long-term Effects of Reducing Intake of Energy study. Changes in RMR, body composition, and metabolic hormones were examined over 12 months of…
Source: NatureCategories: Healthcare Professionals, Latest HeadlinesTweet
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Mashup Score: 2Histone deacetylase 6 inhibition restores leptin sensitivity and reduces obesity - Nature Metabolism - 2 year(s) ago
Inhibiting the cytosolic enzyme histone deacetylase 6 in the periphery is sufficient to improve leptin sensitivity and metabolic outcomes in diet-induced obese mice.
Source: NatureCategories: Healthcare Professionals, Latest HeadlinesTweet
In our August issue: a Comment from Anke Hinney and colleagues discusses how #leptin substitution therapy could potentially mitigate symptoms of #anorexia nervosa (£) https://t.co/zW12wJEWC6 @HinneyAnke @MedEssen @UniklinikEssen @unidue @fgf_nrw @MedizinNRW https://t.co/tmMvwo0nwL