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Mashup Score: 5Targeted TLR9 Agonist Elicits Effective Antitumor Immunity against Spontaneously Arising Breast Tumors - 10 month(s) ago
Key Points. PIP-CpG is a systemically administered, tumor-targeting TLR9 agonist.PIP-CpG drives effective T cell–mediated immunity against spontaneous breast tu
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Mashup Score: 1Antisense Oligonucleotide Therapy Decreases IL-1β Expression and Prolongs Survival in Mutant Nlrp3 Mice - 10 month(s) ago
Key Points. Nlrp3-specific ASO treatment downregulates Nlrp3 expression and IL-1β release in murine CAPS.Nlrp3-specific ASO treatment reduces systemic inflammat
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Mashup Score: 0Th1 Cells Alter the Inflammatory Signature of IL-6 by Channeling STAT Transcription Factors to Alu-like Retroelements - 10 month(s) ago
Key Points. Th1 cells alter the transcriptional output of IL-6 during acute inflammation.IL-6 and IFN-γ activities combine to steer tissue responses to inflamma
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Mashup Score: 4SARS-CoV-2 ORF8 Mediates Signals in Macrophages and Monocytes through MyD88 Independently of the IL-17 Receptor - 10 month(s) ago
Key Points. SARS-CoV-2 ORF8 but not IL-17 upregulates cytokines in monocytes/macrophages.Monocytes and macrophages infected with SARS-CoV-2 do not express IL-17
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Mashup Score: 0Recent Thymic Emigrants Require RBPJ-Dependent Notch Signaling to Transition into Functionally Mature Naive T Cells - 10 month(s) ago
Key Points. Recent thymic emigrants transition into mature naive cells via a CD45RBint stage.Immature naive T cells require Notch signals to undergo functional
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Mashup Score: 0Proteogenomic and V(D)J Analysis of Human Decidual T Cells Highlights Unique Transcriptional Programming and Clonal Distribution - 10 month(s) ago
Key Points. scRNA/CITE-seq results show that decidual T cells maintain a unique transcriptome.Decidual T cells overexpress negative regulators of inflammatory p
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Mashup Score: 0Transcriptional Regulation and Signaling of Type IV IFN with Identification of the ISG Repertoire in an Amphibian Model, Xenopus laevis - 11 month(s) ago
Key Points. IFN-υ can be activated by IRF1, IRF3, IRF7, and p65.The ISG repertoire contains major expanded families of AMNTR, GVIN, GBP, RTP, and IFIT.AMNTR50 n
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Mashup Score: 3Chromatin Regulator Mll1 Supports T Follicular Helper Cell Differentiation by Controlling Expression of Bcl6, LEF-1, and TCF-1 - 11 month(s) ago
Key Points. Mll1 is a positive regulator of TFH differentiation.Mll1 regulates expression of LEF-1, TCF-1, and Bcl6.
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Mashup Score: 0Interaction of Nmi and IFP35 Promotes Mutual Protein Stabilization and IRF3 and IRF7 Degradation to Suppress Type I IFN Production in Teleost Fish - 12 month(s) ago
Key Points. Nmi can interact with IRF3 and IRF7 to regulate negatively type I IFN expression.Nmi and IFP35 can interact with each other to maintain mutual stabi
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Mashup Score: 1Small Molecule RIG-I Agonist Serves as an Adjuvant to Induce Broad Multifaceted Influenza Virus Vaccine Immunity - 1 year(s) ago
Key Points. KIN1148 is a small molecule compound that binds directly to RIG-I for activation.KIN1148 serves as an adjuvant for H1N1 and H5N1 influenza virus vac
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#JI_TopRead from @CaitlynBioE @CochranLab @CarolynBertozzi @StanfordHealth | #TLR9 agonist, PIP-CpG, enhances the CD8 #Tcell response to spontaneous tumors | #ReadTheJI #immunology #AuthorChoice #FreetoRead #TumorImmunology 👉 https://t.co/KdOxutKuLh https://t.co/rb99fBIOLb