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    Colorectal cancer (CRC) development is characterized by stepwise accumulation of mutations, of which the majority display early mutations in tumor suppressor gene APC.1 Previous work revealed that Apc loss confers a competitive advantage to mutant intestinal stem cells (ISCs), which consequently replace all normal ISCs and drive crypt fixation in vivo.2 Recent studies demonstrate that this advantage can be attributed to the secretion of Wnt antagonists (eg, NOTUM/WIF1/DKK2) that drive normal ISC differentiation.

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    • Calling all coffee enthusiasts! Exciting research reveals how caffeine influences #intestinal tumor initiation. Interested in learning more? Click the link ➡️ https://t.co/sqcFBDHSb4 https://t.co/MtQ8Au5Vp5

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    Wolters Kluwer Health - 11 month(s) ago

    JavaScript Error JavaScript has been disabled on your browser. You must enable it to continue. Here’s how to enable JavaScript in the following browsers: Internet Explorer From the Tools menu, select Options Click the Content tab Select Enable JavaScript Firefox From the Tools…

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    • How should providers screen for and manage #irondeficiency in children with #intestinal failure? This new #CME-eligible Society Paper from the @NASPGHAN intestinal failure special interest group provides recommendations! https://t.co/KeaMLAX2Wf https://t.co/Of3P6UAgCb

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    Share on PinterestA new study points to the gut virome as the culprit in intestinal bowel disease. NIH/NAID/IMAGE.FR/BSIP/Universal Images Group via Getty ImagesThe human microbiome contains a community of microorganisms that include viruses. This is called the human virome, a community of both beneficial and pathogenic viruses.The virome begins at birth and may be an equally important factor in…

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    • RT @holistic_Hlth: #microbiome #IBD #Intestinal #virome #INPST #DHPSP #Scicomm #NPMND https://t.co/StGnsxpqJy

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    Using human gastrointestinal tracts from three organ donors, researchers shed renewed insight into the function of different cell types across intestinal regions.

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    • What is the 'cellular atlas of the gut' and how do different cell types behave across #intestinal regions? https://t.co/eNHG41R2wA https://t.co/06zKw97Or9