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    This Review highlights the extrapancreatic actions of the incretin hormones gastric inhibitory polypeptide and glucagon-like peptide 1. These peptides are active on tissues with cardiometabolic relevance, such as liver, adipose tissue, muscle, the immune, kidney, heart, blood vessels and the central nervous system.

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    • In our latest issue: @RolaHammoud1 & @DanielJDrucker discuss the extrapancreatic actions of the #incretin hormones gastric inhibitory polypeptide and glucagon-like peptide 1 (£) https://t.co/sCGmhSgrmy https://t.co/EkYOHCz5r0

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    Drugs like Wegovy and Ozempic are growing in popularity as obesity medications. This STAT explainer video shows how they work in the body.

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    • Watch: How do the new #obesity drugs work? https://t.co/hRJSmebVET via @statnews #glp1 #incretin #semaglutide #wegovy #Ozempic #weightloss

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    The fact that stimulation of insulin is much greater after an oral or enteral rather than isoglycaemic intravenous administration of glucose has been known for more than 60 years—this incretin effect is mediated by two gut hormones—GLP-1 and GIP. Management of people with type 2 diabetes and obesity is being revolutionised with the emergence of increasingly effective therapies based on GLP-1.1…

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    • Michael Horowitz & colleagues comment: Isseki nichō (one stone, two birds): a dual #incretin receptor agonist for type 2 #diabetes https://t.co/53Rxgpocd0 #tirzepatide #Japan #T2D https://t.co/yF51pWBw74

  • Mashup Score: 1

    The fact that stimulation of insulin is much greater after an oral or enteral rather than isoglycaemic intravenous administration of glucose has been known for more than 60 years—this incretin effect is mediated by two gut hormones—GLP-1 and GIP. Management of people with type 2 diabetes and obesity is being revolutionised with the emergence of increasingly effective therapies based on GLP-1.1…

    Tweet Tweets with this article
    • Michael Horowitz & colleagues comment on: Isseki nichō (one stone, two birds): a dual #incretin receptor agonist for type 2 #diabetes https://t.co/53Rxgpocd0 #T2D #tirzepatide https://t.co/1kUcXXA9Px

  • Mashup Score: 1

    The fact that stimulation of insulin is much greater after an oral or enteral rather than isoglycaemic intravenous administration of glucose has been known for more than 60 years—this incretin effect is mediated by two gut hormones—GLP-1 and GIP. Management of people with type 2 diabetes and obesity is being revolutionised with the emergence of increasingly effective therapies based on GLP-1.1…

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    • Also read the Linked Comment: Isseki nichō (one stone, two birds): a dual #incretin receptor agonist for type 2 #diabetes https://t.co/53Rxgpocd0 #T2D #tirzepatide https://t.co/9Bg95Zfsxu