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Mashup Score: 2Upper Extremity Infections in the Transplant Population - 7 month(s) ago
As the duration of lifetime survival after organ transplantation continues to increase, the consequences of long-term immunosuppression, such as opportunistic and rare infections, are a high-risk reality. This study examined upper extremity infections in the transplant population to determine the current clinical risk profile, management, and outcomes.
Source: www.jhandsurg.orgCategories: Latest Headlines, RheumatologyTweet
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Mashup Score: 1JHLT: The Podcast: Episode 33: August 2023 - 8 month(s) ago
The JHLT Digital Media Editors explore two manuscripts from the August issue of The Journal of Heart and Lung Transplantation—the first on immunosuppression in pediatric heart transplantation, and the second TA-NRP in DCD lung transplantation. Digital Media Editor Van-Khue Ton, MD, heart failure and transplant cardiologist at Massachusetts General Hospital, hosts this episode. First, hear from senior author Steven C. Greenway, MSc, MD, on his team’s study “.” Dr. Greenway shares his journey from enzyme biochemistry in mollusks, snails, and frogs to pediatric cardiology, then outlines the results of the paper. The study queried the Pediatric Heart Transplant Society’s registry to determine the efficacy and safety of monotherapy immunosuppression. The results showed better graft survival and less coronary allograft vasculopathy in the monotherapy group, even after adjusted for age at transplant, sex, neonatal transplant, infection, PTLD, and etiology of cardiomyopathy. Dr. Greenway a
Source: thejhlt.libsyn.comCategories: Cardiology News and Journals, Latest HeadlinesTweet-
Listen to the August #JHLTThePodcast for great discussions on #immunosuppression in peds #HeartTx and TA-NRP on early outcomes in #DCD #LungTx from Steven C. Greenway and @JadMalasMD. Check the 🧵thread below for details on the studies, and listen at https://t.co/pVodmrbHMV https://t.co/N7EiMw2ZzB
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Mashup Score: 0Syk Inhibition Reprograms Tumor-Associated Macrophages and Overcomes Gemcitabine-Induced Immunosuppression in Pancreatic Ductal Adenocarcinoma - 8 month(s) ago
Syk blockade induces macrophage polarization to an immunostimulatory phenotype, which enhances CD8+ T-cell responses and improves gemcitabine efficacy in pancreatic ductal adenocarcinoma, a clinically challenging malignancy.
Source: aacrjournals.orgCategories: Hem/Onc News and Journals, Latest HeadlinesTweet-
From the most recent issue— Syk Inhibition Reprograms Tumor-Associated Macrophages and Overcomes Gemcitabine-Induced #Immunosuppression in #Pancreatic Ductal #Adenocarcinoma, by Rohila et al. https://t.co/gUqHWv5r7b @UCSDCancer https://t.co/9pAP6btBCZ
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Mashup Score: 0JHLT: The Podcast: Episode 33: August 2023 - 8 month(s) ago
The JHLT Digital Media Editors explore two manuscripts from the August issue of The Journal of Heart and Lung Transplantation—the first on immunosuppression in pediatric heart transplantation, and the second TA-NRP in DCD lung transplantation. Digital Media Editor Van-Khue Ton, MD, heart failure and transplant cardiologist at Massachusetts General Hospital, hosts this episode. First, hear from senior author Steven C. Greenway, MSc, MD, on his team’s study “.” Dr. Greenway shares his journey from enzyme biochemistry in mollusks, snails, and frogs to pediatric cardiology, then outlines the results of the paper. The study queried the Pediatric Heart Transplant Society’s registry to determine the efficacy and safety of monotherapy immunosuppression. The results showed better graft survival and less coronary allograft vasculopathy in the monotherapy group, even after adjusted for age at transplant, sex, neonatal transplant, infection, PTLD, and etiology of cardiomyopathy. Dr. Greenway a
Source: thejhlt.libsyn.comCategories: Cardiology News and Journals, Latest HeadlinesTweet-
Have you listened to the August #JHLTThePodcast yet? Great stuff on #immunosuppression in peds #HeartTx and TA-NRP on early outcomes in #DCD #LungTx from Steven C. Greenway and @JadMalasMD! Check the thread🧵below for details on the studies, and listen at https://t.co/pVodmrbHMV https://t.co/N7EiMw2ZzB
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Mashup Score: 0Single-drug immunosuppression is associated with noninferior medium-term survival in pediatric heart transplant recipients - 9 month(s) ago
Patients are usually maintained on at least 2 immunosuppressive drugs (ISDs) after the first year post heart transplant. Anecdotally, some children are switched to single-drug monotherapy (a single ISD) for various reasons and varying durations. Outcomes associated with differences in immunosuppression after heart transplantation are unknown for children.
Source: www.jhltonline.orgCategories: Cardiology News and Journals, Latest HeadlinesTweet-
1⃣ Senior author Steven C. Greenway @UCalgaryMed shares the team's study on single-drug #immunosuppression in #pediaric #HeartTx. Learn about their findings on the safety and efficacy of #monotherapy based on the @PHTSociety registry: https://t.co/LpwftDCKwt
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Mashup Score: 0
Tumors induce systemic immunosuppression that outlasts tumor burden via osteoprogenitor (OP)–GMP cross-talk.
Categories: Hem/Onc News and Journals, Latest HeadlinesTweet-
Read this week's #ResearchWatch: Tumors Induce Systemic #Immunosuppression through Osteoprogenitor–GMP Cross-talk, a summary of the paper by Xiaoxin Hao, Yichao Shen, @XiangHFZhang1, @lab_bcm et al. https://t.co/Roi4E9Ttrd @bcmhouston https://t.co/VMYYnZDYJn
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Mashup Score: 2CD73-Dependent Adenosine Signaling through Adora2b Drives Immunosuppression in Ductal Pancreatic Cancer - 1 year(s) ago
Ductal-derived pancreatic tumors have elevated epithelial and CD8+GZM+ T-cell CD73 expression that confers sensitivity to small-molecule inhibition of CD73 or Adora2b to promote CD8+ T-cell–mediated tumor regression.
Categories: Hem/Onc News and Journals, Latest HeadlinesTweet-
In pancreatic ductal adenocarcinoma, Faraoni et al. have identified that CD73 as a key determinant of #immunosuppression and a therapeutic target to promote immune-mediated tumor regression. https://t.co/m0k2yN1cNy @UTHealthHouston https://t.co/QqCXRTd73R
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Mashup Score: 1
Immunosuppression is a well-documented risk factor for skin cancer, as exemplified by the 65- to 250-fold higher squamous cell carcinoma risk, 10-fold higher basal cell carcinoma risk, and 0 to 8-fold higher melanoma risk in solid organ transplant recipients (SOTRs) receiving potent, prolonged courses of immunosuppressive therapies. Numerous immune system components have been shown to either…
Categories: Dermatology, Latest HeadlinesTweet-
#Immunosuppression is a well-documented risk factor for #skincancer, exemplified by a 65-250 fold higher SCC risk, 10-fold higher BCC risk, and 0-8 fold higher melanoma risk in solid organ transplant recipients with prolonged immunosuppressive therapies. https://t.co/2zvdSKQ3Yv
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Mashup Score: 1Androgen Signaling Contributes to Sex Differences in Cancer by Inhibiting NF-κB Activation in T Cells and Suppressing Antitumor Immunity - 1 year(s) ago
Androgen signaling induces immunosuppression in cancer by blocking T-cell activity through upregulation of USP18 and subsequent inhibition of NF-κB activity, providing a targetable axis to improve antitumor immunity in males.
Categories: Hem/Onc News and Journals, Latest HeadlinesTweet-
Zhang et al. find that androgen signaling induces #immunosuppression in cancer by blocking #Tcell activity, uncovering a mechanism underlying sex differences in cancer and providing a targetable axis to improve antitumor immunity in males. https://t.co/WMlULQw7Vz https://t.co/HaR9QCGIWF
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Mashup Score: 0Androgen Signaling Contributes to Sex Differences in Cancer by Inhibiting NF-κB Activation in T Cells and Suppressing Antitumor Immunity - 1 year(s) ago
Androgen signaling induces immunosuppression in cancer by blocking T-cell activity through upregulation of USP18 and subsequent inhibition of NF-κB activity, providing a targetable axis to improve antitumor immunity in males.
Categories: Hem/Onc News and Journals, Latest HeadlinesTweet-
Zhang et al. find that androgen signaling induces #immunosuppression in cancer by blocking #Tcell activity, uncovering a mechanism underlying sex differences in cancer and providing a targetable axis to improve antitumor immunity in males. https://t.co/zEJfhfCuap https://t.co/G0jTgBZZgD
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#UpperExtremityInfections in the #Transplant Population @ClevelandClinic #HandInfection #Immunosuppression #OrganTransplantation #Outcomes #HandSurgery https://t.co/A1u3a3SkQD