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    R-loops are RNA-DNA-hybrid-containing nucleic acids with important cellular roles. Deregulation of R-loop dynamics can lead to DNA damage and genome instability1, which has been linked to the action of endonucleases such as XPG2-4. However, the mechanisms and cellular consequen …

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    • SCI member Karlene Cimprich and others reveal a new mechanistic connection linking R-loop deregulation and processing with innate immune activation that could be relevant to many human diseases, such as cancer. https://t.co/iEJdx3y6nq #immuneresponse https://t.co/j6C0eja2Um

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    Editor’s Picks Dr. Earl D. Silverman, MD, shares his monthly Editor’s Picks and their relevance in current clinical practice: December 2022 Featured articles:​ Koo, et al: Relationship Between Inflammation and Radiographic Progression in Patients With Ankylosing Spondylitis Attaining a BASDAI of Less Than 4 During Tumor Necrosis Factor Inhibitor Treatment Sun, et al: Development and…

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    • 🎙️ December 2022 Editor's Picks Podcast 🎧 https://t.co/pfyQc6gLXf #immuneresponse #vaccine #coronavirus #rheumatoidarthritis https://t.co/vDnY5S9wyZ