-
Mashup Score: 1Enhancing Hepatitis B Screening Aiming Towards Elimination Goals - 1 month(s) ago
Wireless test kit transforms screening efforts towards combating the virus.
Source: www.contagionlive.comCategories: General Medicine News, Infectious DiseaseTweet
-
Mashup Score: 1Need for Hepatitis B Clinical Trials in Africa - 2 month(s) ago
Shortage in hepatitis b virus (HBV) clinical trials within the WHO African region.
Source: www.contagionlive.comCategories: General Medicine News, Infectious DiseaseTweet
-
Mashup Score: 1Phenotypic CD8 T cell profiling in chronic hepatitis B to predict HBV-specific CD8 T cell susceptibility to functional restoration in vitro - 6 month(s) ago
Objective Exhausted hepatitis B virus (HBV)-specific CD8 T cells in chronic HBV infection are broadly heterogeneous. Characterisation of their functional impairment may allow to distinguish patients with different capacity to control infection and reconstitute antiviral function. Design HBV dextramer+CD8 T cells were analysed ex vivo for coexpression of checkpoint/differentiation markers, transcription factors and cytokines in 35 patients with HLA-A2+chronic hepatitis B (CHB) and in 29 control HBsAg negative CHB patients who seroconverted after NUC treatment or spontaneously. Cytokine production was also evaluated in HBV peptide-stimulated T cell cultures, in the presence or absence of antioxidant, polyphenolic, PD-1/PD-L1 inhibitor and TLR-8 agonist compounds and the effect on HBV-specific responses was further validated on additional 24 HLA-A2 negative CHB patients. Results Severely exhausted HBV-specific CD8 T cell subsets with high expression of inhibitory receptors, such as PD-1,
Source: gut.bmj.comCategories: Gastroenterology, Latest HeadlinesTweet
-
Mashup Score: 6HIV pre-exposure prophylaxis as an entry point to the elimination of hepatitis B virus - 8 month(s) ago
In 2022, the Global Fund to Fight AIDS, Tuberculosis and Malaria made a welcome move to enable increased financial support for viral hepatitis. International organisations and patient groups have called on countries to include viral hepatitis prevention and treatment services in their national proposals to the Global Fund, and also called on funders such as the US President’s Emergency Plan for AIDS Relief (PEPFAR) to integrate viral hepatitis into their programmes.1
Source: www.thelancet.comCategories: Gastroenterology, Latest HeadlinesTweet
-
Mashup Score: 3
An estimated 20–30% of people with hepatitis B virus (HBV) infection will die in the absence of antiviral treatment.1 Until now, international liver society guidelines have been based on the same logic: to try to identify these higher risk patients so that treatment can be initiated before they develop irreversible complications.2–4 Typically, treatment decisions are based on clinical signs, liver fibrosis assessment by transient elastography, and blood tests such as serum aminotransferase and HBV DNA concentrations.
Source: www.thelancet.comCategories: Gastroenterology, Latest HeadlinesTweet
-
Mashup Score: 7Targeted viral adaptation generates a simian-tropic hepatitis B virus that infects marmoset cells - 9 month(s) ago
Nature Communications – Hepatitis B virus is an almost uniquely human-tropic pathogen for which model systems are scarce. Here, the authors determine key residues within the HBV receptor that form…
Source: www.nature.comCategories: General Medicine News, Latest HeadlinesTweet
-
Mashup Score: 3Targeted viral adaptation generates a simian-tropic hepatitis B virus that infects marmoset cells - 9 month(s) ago
Nature Communications – Hepatitis B virus is an almost uniquely human-tropic pathogen for which model systems are scarce. Here, the authors determine key residues within the HBV receptor that form…
Source: www.nature.comCategories: General Medicine News, Latest HeadlinesTweet
-
Mashup Score: 0WHO 2030 HBV elimination goals: a goal too far? - 9 month(s) ago
In The Lancet Gastroenterology & Hepatology, the Polaris Observatory Collaborators report their latest iteration of the modelling of HBV prevalence, cascade of care, and prophylaxis.1 Some refinements have been made to the modelling, with better quality data, which have led to an estimated global burden of HBV infection of 257·5 million (95% uncertainty interval 216·6–316·4) in 2022—a reduction of around 34·5 million cases compared with the 292·0 million estimated for 2016.2 By contrast, Cui and colleagues’ recent study,3 which used WHO-collected data, estimated that 295·9 million (95% CI 228·2–422·6) people were living with chronic HBV infection in 2019.
Source: www.thelancet.comCategories: Gastroenterology, Latest HeadlinesTweet
-
Mashup Score: 10Poor disease knowledge among people living with hepatitis B in The Gambia and Tanzania - 9 month(s) ago
In 2008, the World Hepatitis Alliance launched the World Hepatitis Day in honour of the birthday of Dr Baruch Blumberg (July 28, 1925), who discovered the hepatitis B virus (HBV) in 1967. The worldwide number of deaths per year attributable to HBV was estimated at 700 000 in 2013. This number is projected to increase to 1·3 million per year by 2040, which is more than the annual number of deaths related to HIV/AIDS (741 000), tuberculosis (875 000), or malaria (332 000).1
Source: www.thelancet.comCategories: Gastroenterology, Latest HeadlinesTweet
-
Mashup Score: 0Global prevalence, cascade of care, and prophylaxis coverage of hepatitis B in 2022: a modelling study - 9 month(s) ago
As 2030 approaches, the elimination targets remain out of reach for many countries under the current frameworks. Although prevention measures have had the most success, there is a need to increase these efforts and to increase diagnosis and treatment to work towards the elimination goals.
Source: www.thelancet.comCategories: Gastroenterology, Latest HeadlinesTweet
Enhancing Hepatitis B #HBV Screening with a Wireless Test Kit Aims to Transform Efforts Toward Combating the Virus. https://t.co/6Bzt4UoLes https://t.co/ieyo0SsCXH