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Mashup Score: 35
Dysfunctions in growth hormone (GH) secretion increase the prevalence of anxiety and other neuropsychiatric diseases. GH receptor (GHR) signaling in the amygdala has been associated with fear memory, a key feature of posttraumatic stress disorder. However, it is currently unknown which neuronal population is targeted by GH action to influence the development of neuropsychiatric diseases. Here, we showed that approximately 60% of somatostatin (SST)-expressing neurons in the extended amygdala are directly responsive to GH. GHR ablation in SST-expressing cells (SSTΔGHR mice) caused no alterations in energy or glucose metabolism. Notably, SSTΔGHR male mice exhibited increased anxiety-like behavior in the light-dark box and elevated plus maze tests, whereas SSTΔGHR females showed no changes in anxiety. Using auditory Pavlovian fear conditioning, both male and female SSTΔGHR mice exhibited a significant reduction in fear memory. Conversely, GHR ablation in SST neurons did not affect memory i
Source: www.jneurosci.orgCategories: General Medicine News, General HCPsTweet
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Mashup Score: 4Diffuse traumatic brain injury substantially alters plasma growth hormone in the juvenile rat - 4 month(s) ago
Traumatic brain injury (TBI) can damage the hypothalamus and cause improper activation of the growth hormone (GH) axis, leading to growth hormone deficiency (GHD). GHD is one of the most prevalent endocrinopathies following TBI in adults; however, the extent to which GHD affects juveniles remains understudied. We used postnatal day 17 rats (n = 83), which model the late infantile/toddler period, and assessed body weights, GH levels, and number of hypothalamic somatostatin neurons at acute (1, 7 days post injury (DPI)) and chronic (18, 25, 43 DPI) time points. We hypothesized that diffuse TBI would alter circulating GH levels because of damage to the hypothalamus, specifically somatostatin neurons. Data were analyzed with generalized linear and mixed effects models with fixed effects interactions between the injury and time. Despite similar growth rates over time with age, TBI rats weighed less than shams at 18 DPI (postnatal day 35; P = 0.03, standardized effect size [d] = 1.24), which
Source: joe.bioscientifica.comCategories: General Medicine News, EndocrinologyTweet-
📍 Diffuse traumatic brain injury substantially alters plasma #growth #hormone in the juvenile rat By J Bryce Ortiz et al. @barrowpch @uazmedphx @rachelrowephx @CUBoulderIPHY 👉 Read it here: https://t.co/BCc4Loe3CD https://t.co/Y71J0L8tZ8
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Mashup Score: 0
Tackling the mechanisms underlying ageing is desirable to help to extend the duration and improve the quality of life. Life extension has been achieved in animal models by suppressing the growth hormone–insulin-like growth factor 1 (IGF-1) axis and also via dietary restriction. Metformin has become the focus of increased interest as a possible anti-ageing drug. There is some overlap in the…
Categories: Endocrinology, Latest HeadlinesTweet-
Mechanisms of #ageing: growth hormone, dietary restriction, and metformin https://t.co/v3xVZPA1I0 #aging #antiaging #metformin #GrowthHormone #DietaryRestriction
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Mashup Score: 1
Tackling the mechanisms underlying ageing is desirable to help to extend the duration and improve the quality of life. Life extension has been achieved in animal models by suppressing the growth hormone–insulin-like growth factor 1 (IGF-1) axis and also via dietary restriction. Metformin has become the focus of increased interest as a possible anti-ageing drug. There is some overlap in the…
Categories: Endocrinology, Latest HeadlinesTweet-
Mechanisms of #ageing: growth hormone, dietary restriction, and metformin https://t.co/v3xVZPA1I0 #aging #antiaging #metformin #GrowthHormone #DietaryRestriction https://t.co/FmeKMjCfAJ
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Mashup Score: 0
Márta Korbonits talks with The Lancet Diabetes & Endocrinology about mechanisms of ageing: growth hormone, dietary restriction, and metformin.Read the full article:Mechanisms of ageing: growth hormone, dietary restriction, and metformin
Source: BuzzsproutCategories: Endocrinology, Latest HeadlinesTweet-
Also listen to the Linked Podcast: Márta Korbonits talks with The Lancet Diabetes & Endocrinology about mechanisms of ageing: growth hormone, dietary restriction, and metformin https://t.co/MhcWznKbhF #aging #antiaging #metformin #GrowthHormone #DietaryRestriction
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Mashup Score: 0
Márta Korbonits talks with The Lancet Diabetes & Endocrinology about mechanisms of ageing: growth hormone, dietary restriction, and metformin.Read the full article:Mechanisms of ageing: growth hormone, dietary restriction, and metformin
Source: BuzzsproutCategories: Endocrinology, Latest HeadlinesTweet-
In conversation with.... Márta Korbonits talks with The Lancet Diabetes & Endocrinology about mechanisms of #ageing: growth hormone, dietary restriction, and #metformin https://t.co/MhcWznKbhF #aging #antiaging #DietaryRestriction #GrowthHormone
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Mashup Score: 1
Tackling the mechanisms underlying ageing is desirable to help to extend the duration and improve the quality of life. Life extension has been achieved in animal models by suppressing the growth hormone–insulin-like growth factor 1 (IGF-1) axis and also via dietary restriction. Metformin has become the focus of increased interest as a possible anti-ageing drug. There is some overlap in the…
Categories: Endocrinology, Latest HeadlinesTweet-
In this Review, we examine the evidence for the effect of growth hormone, dietary restriction, and #metformin on #ageing, and postulate the possible overlapping mechanisms at play https://t.co/v3xVZPAzxy #aging #antiaging #DietaryRestriction #GrowthHormone https://t.co/ADCk2dEdRk
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Mashup Score: 151
Tackling the mechanisms underlying ageing is desirable to help to extend the duration and improve the quality of life. Life extension has been achieved in animal models by suppressing the growth hormone–insulin-like growth factor 1 (IGF-1) axis and also via dietary restriction. Metformin has become the focus of increased interest as a possible anti-ageing drug. There is some overlap in the…
Categories: Endocrinology, Latest HeadlinesTweet-
In this Review, we draw on evidence from both animal models and human studies to assess the effects of suppression of the growth hormone–IGF-1 axis, dietary restriction, and metformin on #ageing https://t.co/v3xVZPAzxy #metformin #GrowthHormone #DietaryRestriction #antiageing
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Mashup Score: 5
Márta Korbonits talks with The Lancet Diabetes & Endocrinology about mechanisms of ageing: growth hormone, dietary restriction, and metformin.Read the full article:Mechanisms of ageing: growth hormone, dietary restriction, and metformin
Source: BuzzsproutCategories: Endocrinology, Latest HeadlinesTweet-
In conversation with.... Márta Korbonits talks with The Lancet Diabetes & Endocrinology about mechanisms of #ageing: growth hormone, dietary restriction, and metformin https://t.co/MhcWznKJ7d #metformin #GrowthHormone #DietaryRestriction #antiageing
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Mashup Score: 8
Tackling the mechanisms underlying ageing is desirable to help to extend the duration and improve the quality of life. Life extension has been achieved in animal models by suppressing the growth hormone–insulin-like growth factor 1 (IGF-1) axis and also via dietary restriction. Metformin has become the focus of increased interest as a possible anti-ageing drug. There is some overlap in the…
Categories: Endocrinology, Latest HeadlinesTweet-
Mechanisms of #ageing: growth hormone, dietary restriction, and metformin https://t.co/v3xVZPAzxy #aging #metformin #GrowthHormone #AntiAging #DietaryRestriction https://t.co/2uI9JCVBri
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#GrowthHormone found to influence regulation of anxiety via a specific group of neurons @sfnjournals https://t.co/91ksLnEEMu https://t.co/KAAXNsspWh