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Mashup Score: 5
Inactivation of N-linked glycosylation of the B-cell receptor (BCR) by OST-B in diffuse large B-cell lymphoma reduces clustering, internalization, and downstream signaling of BCR, suggesting OST-B may be a potential therapeutic target in lymphoma.
Source: aacrjournals.orgCategories: Hem/Onc News and Journals, Latest HeadlinesTweet
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Mashup Score: 0Targeting N-linked Glycosylation for the Therapy of Aggressive Lymphomas - 11 month(s) ago
Abstract. Diffuse large B-cell lymphoma (DLBCL) can be subdivided into activated B-cell like (ABC) and germinal center B-cell-like (GCB) DLCBL. Self-antigen engagement of B-cell receptors (BCRs) in ABC tumors induces their clustering, thereby initiating chronic active signaling and activation of NF-kB and PI3 kinase. Constitutive BCR signaling is essential in some GCB tumors but primarily…
Categories: Hem/Onc News and Journals, Latest HeadlinesTweet-
#ICYMI— Targeting N-linked #Glycosylation for the Therapy of Aggressive #Lymphoma, by Sebastian Scheich, Louis Staudt et al. https://t.co/p3UHlBGIAE @theNCI @NCIgenomics https://t.co/uwbl8J6DZo
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Mashup Score: 2Targeting N-linked Glycosylation for the Therapy of Aggressive Lymphomas - 12 month(s) ago
Abstract. Diffuse large B-cell lymphoma (DLBCL) can be subdivided into activated B-cell like (ABC) and germinal center B-cell-like (GCB) DLCBL. Self-antigen engagement of B-cell receptors (BCRs) in ABC tumors induces their clustering, thereby initiating chronic active signaling and activation of NF-kB and PI3 kinase. Constitutive BCR signaling is essential in some GCB tumors but primarily…
Categories: Hem/Onc News and Journals, Latest HeadlinesTweet-
Targeting N-linked #Glycosylation for the Therapy of Aggressive #Lymphoma— by Sebastian Scheich, Louis Staudt et al. https://t.co/LeZCMk3oT8 @theNCI @NCIgenomics https://t.co/wWXSmL8neK
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Mashup Score: 8Glycobiology of rheumatic diseases - Nature Reviews Rheumatology - 1 year(s) ago
Glycosylation is a common modification that can affect protein stability and interactions. In this Review, the authors discuss the role of glycosylation in rheumatic diseases, as well as the therapeutic potential of glycosylation-based interventions.
Source: NatureCategories: Latest Headlines, RheumatologyTweet-
Learn about the role of #Glycosylation in rheumatic diseases and potential glycosylation-based interventions in this latest #Review from @kisselth and colleagues @LUMC_Leiden https://t.co/JwgIImrLsy https://t.co/Zl6luduLIi
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Mashup Score: 2Plasmalogen-Mediated Activation of GPCR21 Regulates Cytolytic Activity of NK Cells against the Target Cells - 2 year(s) ago
It is widely known that the immune system becomes slower to respond among elderly people, making them more susceptible to viral infection and cancer. The mechanism of aging-related immune deficiency remained mostly elusive. In this article, we report that plasmalogens (Pls), special phospholipids
Source: The Journal of ImmunologyCategories: Allergy-Immunology, Latest HeadlinesTweet-
#AuthorChoice: #plasmalogens can stimulate #NKcells to increase cytolysis from Md Shamim Hossain #FreetoRead #ReadTheJI #immunology #glycosylation https://t.co/6IlIZxPCVu https://t.co/0Uidye1Rxb
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Mashup Score: 34How One Change to The Coronavirus Spike Influences Infectivity - 2 year(s) ago
Since joining NIH, I’ve held a number of different leadership positions. But there is one position that thankfully has remained constant for me: lab chief. I run my own research lab at NIH’s Nation…
Source: NIH Director's BlogCategories: Healthcare Professionals, Latest HeadlinesTweet-
A new study suggests that part of the #delta #variant’s secret is explained by a biochemical process known as #glycosylation. How it works on the NIH Director’s Blog. #NIH https://t.co/QXTWwIPlXM
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Mashup Score: 0
To describe the clinical, biochemical, and genetic features of both new and previously reported patients with congenital disorders of glycosylation (CDGs) diagnosed in Portugal over the last 20 years.
Source: The Journal of PediatricsCategories: Latest Headlines, PediatricsTweet-
Quelhas et al describe the clinical, biochemical, and genetic features of both new and previously reported patients with congenital disorders of #glycosylation (CDGs) diagnosed in Portugal over the last 20 years. https://t.co/yIdqlsGaaP https://t.co/m6VrmcNEkB
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Mashup Score: 0Secret3D Workflow for Secretome Analysis: STAR Protocols - 3 year(s) ago
Summary Secretome analysis is crucial to unravel extracellular processes. However, secreted proteins are difficult to detect in mass-spectrometry-based analysis due to contamination of serum proteins deriving from cell culture media and to high glycosylation, which hampers tryptic digestion. Secret3D workflow is an optimized protocol for the global analysis of secretome…
Source: star-protocols.cell.comCategories: General Medicine News, Latest HeadlinesTweet-
Check out this #protocol by Dr. Bachi @IFOMresearch, describing Secret3D workflow for the analysis of #secretome from cultured cells, allowing efficient and robust identification of secreted proteins and their putative #glycosylation sites @STARProtocols: https://t.co/8W9GRZp9HR https://t.co/iAS4zd8fnD
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Mashup Score: 5When molecules collide: new method for analyzing sugar-protein interactions could enable better biologic drugs - 3 year(s) ago
The method, aimed at predicting how sugars stabilize proteins, should have broad applications in biology and medicine. March 15, 2021 LA JOLLA, CA—Scientists at Scripps Research have found a new way to explain how small sugar molecules called glycans can help stabilize proteins that form the basis of certain medicines. The new approach represents a powerful tool for basic…
Source: www.scripps.eduCategories: General Medicine News, Latest HeadlinesTweet-
With the help of #AI and #quantummechanics, Prof. Jeff Kelly’s lab has found a new way to predict protein stabilization by #glycosylation. Understanding these interactions could lead to better, more affordable biologic drugs https://t.co/b3uYfh5TkS @NatureChemistry https://t.co/inUYYiTJuU
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Mashup Score: 5
Glycosylation is the most abundant and diverse form of protein post-translational modification. Recent technical developments are enabling the dissection of the glycome in single cells, providing new insights into its regulation and roles in physiology and disease, and new possibilities for controlling glycosylation for therapy.
Categories: Allergy-Immunology, Latest HeadlinesTweet-
Take a global view of human protein glycosylation pathways and functions with this super-comprehensive #Review by Henrik Clausen an co. @cphglyco @hirenj @kattesch #glycosylation #glcome #glycoprotein https://t.co/mxV4PUM6P9 !FREE! pdf: https://t.co/02zbQP0X4B https://t.co/BnTLY2M7vA
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From the August issue— Targeting N-linked #Glycosylation for the Therapy of Aggressive #Lymphoma, by Sebastian Scheich, Louis Staudt et al. https://t.co/I57mgPe7fk @theNCI @NCIgenomics https://t.co/zUBaIdVp05