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Mashup Score: 0Low-Dose Glucocorticoids Lead to Modest Weight Gain in RA - 8 month(s) ago
Although patients in both the intervention and control cohorts gained weight, patients treated with glucocorticoids gained an average of 1.1 kg more than controls.
Source: www.hcplive.comCategories: Latest Headlines, RheumatologyTweet
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Mashup Score: 0
11β-Hydroxysteroid dehydrogenase 1 (11βHSD1) is a drug target to attenuate adverse effects of chronic glucocorticoid excess. It catalyses intracellular regeneration of active glucocorticoids in tissues including brain, liver and adipose tissue (coupled to hexose-6-phosphate dehydrogenase, H6PDH). 11βHSD1 activity in individual tissues is thought to contribute significantly to glucocorticoid levels at those sites, but its local contribution vs glucocorticoid delivery via the circulation is unknown. Here, we hypothesised that hepatic 11βHSD1 would contribute significantly to the circulating pool. This was studied in mice with Cre-mediated disruption of Hsd11b1 in liver (Alac-Cre) vs adipose tissue (aP2-Cre) or whole-body disruption of H6pdh. Regeneration of [9,12,12-2H3]-cortisol (d3F) from [9,12,12-2H3]-cortisone (d3E), measuring 11βHSD1 reductase activity was assessed at steady state following infusion of [9,11,12,12-2H4]-cortisol (d4F) in male mice. Concentrations of steroids in plasm
Source: joe.bioscientifica.comCategories: Endocrinology, Latest HeadlinesTweet-
📢 New reasearch: Contribution of local regeneration of #glucocorticoids to tissue steroid pools By S Khan (@shazias51) et al. @EdinUniCVS @EdinburghUni @RuthAndrewMSEd Read this open-access article 🆓👉 https://t.co/bB68ne3gNu https://t.co/oEBg422isl
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Mashup Score: 4Viewpoint: Glucocorticoids in the Treatment of Rheumatoid Arthritis: Points to (Re)consider - 10 month(s) ago
Abstract. Glucocorticoids (prednisone) are essential in the treatment of rheumatoid arthritis and other autoimmune diseases. They are widely used, but treatment
Source: OUP AcademicCategories: Latest Headlines, RheumatologyTweet-
Is it time to reconsider #glucocorticoids in #RheumatoidArthritis? In a new Viewpoint 👀, Maarten Boers discusses: ⭐ GC efficacy in RA ⭐ Acceptable levels of harm ⭐ Current recommendations & their issues ⭐ GCs as bridge & prolonged therapy https://t.co/wdfqxkDkWW
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Mashup Score: 1NEJM Journal Watch: Summaries of and commentary on original medical and scientific articles from key medical journals - 10 month(s) ago
NEJM Journal Watch reviews over 250 scientific and medical journals to present important clinical research findings and insightful commentary
Source: www.jwatch.orgCategories: Healthcare Professionals, Latest HeadlinesTweet-
Should Patients w/ #Sepsis Receive #Glucocorticoids? R Pirracchio MD, et al. https://t.co/JUjb84pctG @NEJM @JWatch [subscription] https://t.co/unnwzzA2UT
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Mashup Score: 6
Objectives Macrophage activation syndrome (MAS) is a severe, life-threatening complication of systemic juvenile idiopathic arthritis (sJIA) and adult-onset Still’s disease (AOSD). The objective of this study was to confirm the adequacy of an emapalumab dosing regimen in relation to interferon-γ (IFNγ) activity by assessing efficacy and safety. The efficacy outcome was MAS remission by week 8,…
Source: Annals of the Rheumatic DiseasesCategories: Latest Headlines, RheumatologyTweet-
⚠️ #MAS is a life-threatening complication of #sJIA & #AOSD 🔥 ⚗️ #emapalumab -anti-IFNγ- was administered to 14 pts who had previously failed high-dose #glucocorticoids, with or without #anakinra and/or #ciclosporin 📉 remission in 13/14 pts 👉 Link: https://t.co/L96b8wdXjX https://t.co/kv2K1DwPAh
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Mashup Score: 0Rheumatoid Arthritis Quiz: Bridging Therapy - 1 year(s) ago
Glucocorticoids are sometimes used as “bridging” therapy to alleviate symptoms in newly diagnosed patients with rheumatoid arthritis until a disease-modifying antirheumatic drug (DMARD) kicks in. Test your knowledge of bridging therapy with this quiz.
Source: HCP LiveCategories: General Medicine News, Latest HeadlinesTweet-
#Glucocorticoids are sometimes used as “bridging” therapy to alleviate symptoms in newly diagnosed patients with #RheumatoidArthritis until a disease-modifying antirheumatic drug (DMARD) kicks in. Test your knowledge of bridging therapy with this quiz. https://t.co/55pCbkDkH2
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Mashup Score: 0Rheumatoid Arthritis Quiz: Tapering Glucocorticoids - 1 year(s) ago
When is the right time to taper glucocorticoids and what is the correct approach? Take this quiz to test your knowledge.
Source: HCP LiveCategories: Latest Headlines, RheumatologyTweet-
When is the right time to taper #glucocorticoids in #RheumatoidArthritis treatment? What is the correct approach? Test your knowledge with this quiz: https://t.co/ktnlfd7Mo4 #RheumatoidArthritis
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Mashup Score: 0Rheumatoid Arthritis Quiz: Tapering Glucocorticoids - 1 year(s) ago
When is the right time to taper glucocorticoids and what is the correct approach? Take this quiz to test your knowledge.
Source: HCP LiveCategories: General Medicine News, Latest HeadlinesTweet-
When is the right time to taper #glucocorticoids and what is the correct approach? Take this quiz to test your knowledge: https://t.co/3OEEHGhA9H #RheumatoidArthritis
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Mashup Score: 2Tapering Glucocorticoids >2.5 mg/day Effectively Reduces Flare Risk in Patients with Rheumatoid Arthritis - 1 year(s) ago
Despite EULAR recommendations encouraging the tapering of glucocorticoids and the rapidly expanding treatment options for patients with rheumatoid arthritis, glucocorticoids are still commonly prescribed to reduce inflammation and manage disease activity.
Source: HCP LiveCategories: Latest Headlines, RheumatologyTweet-
Despite EULAR recommendations encouraging the tapering of #glucocorticoids, patients with #RheumatoidArthritis are still commonly prescribed the drug to reduce inflammation and manage disease activity. https://t.co/rAHxHjeIoe
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Mashup Score: 2
Anti-osteoporotic treatment resulted in increased BMD to a greater extent in patients treated with less than 5 mg per day of prednisone.
Source: Rheumatology NetworkCategories: Latest Headlines, RheumatologyTweet-
The use of #glucocorticoids resulted in BMD loss for women with rheumatic diseases. Learn more:' https://t.co/tGP6YH08CR
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Although patients in both the intervention and control cohorts gained weight, patients treated with #glucocorticoids gained an average of 1.1 kg more than controls. https://t.co/1cw7M77ogv #RheumatoidArthritis