• Mashup Score: 3

    Topoisomerases have essential roles in transcription, DNA replication, chromatin remodelling and, as recently revealed, 3D genome organization. However, topoisomerases also generate DNA–protein crosslinks coupled with DNA breaks, which are increasingly recognized as a source of disease-causing genomic damage.

    Tweet Tweets with this article
    • Fantastic #Review from Yves Pommier, André Nussenzweig, Shunichi Takeda & Caroline Austin Human #topoisomerases and their roles in #genomestability and organization @NCIResearchCtr @nussenza #genomicinstability #DNAdamage 👉https://t.co/XJM4pbx0Co https://t.co/vZ2ffzOiQh

  • Mashup Score: 3

    G-quadruplexes (G4s) are structures formed in guanine-rich DNA or RNA, which are linked to transcription, translation, chromatin biology, genome instability and RNA modifications. Recent studies connect G4 formation with cancer-cell lethality and indicate that G4s could be therapeutic targets.

    Tweet Tweets with this article
    • From August cover #Review by Shankar Balasubramanian on the regulation and functions of DNA and RNA G-quadruplexes @Cambridge_Uni #Gquadruplexes #genomicinstability #cancer Access here: https://t.co/TZ52Z6OBJd https://t.co/ozIvNX4XX7