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Mashup Score: 1Blocking Genomic Instability Prevents Acquired Resistance to MAPK Inhibitor Therapy in Melanoma - 11 month(s) ago
Focal amplicons via extrachromosomal DNA and intrachromosomal complex genomic rearrangements drive acquired MAPK inhibitor resistance, revealing nonhomologous end-joining DNA repair as key to their biogenesis and thereby DNA-PKCS as a cotarget to prevent resistance.
Categories: Hem/Onc News and Journals, Latest HeadlinesTweet
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Mashup Score: 3Blocking Genomic Instability Prevents Acquired Resistance to MAPK Inhibitor Therapy in Melanoma - 1 year(s) ago
Abstract. Blocking cancer genomic instability may prevent tumor diversification and escape from therapies. We show that, after MAPK inhibitor (MAPKi) therapy in patients and patient-derived xenografts (PDXs), acquired-resistant genomes of metastatic cutaneous melanoma specifically amplify resistance-driver, non-homologous end-joining (NHEJ), and homologous recombination repair (HRR) genes via…
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Mashup Score: 0Blocking Genomic Instability Prevents Acquired Resistance to MAPK Inhibitor Therapy in Melanoma - 1 year(s) ago
Abstract. Blocking cancer genomic instability may prevent tumor diversification and escape from therapies. We show that, after MAPK inhibitor (MAPKi) therapy in patients and patient-derived xenografts (PDXs), acquired-resistant genomes of metastatic cutaneous melanoma specifically amplify resistance-driver, non-homologous end-joining (NHEJ), and homologous recombination repair (HRR) genes via…
Categories: Hem/Onc News and Journals, Latest HeadlinesTweet
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Mashup Score: 3Human topoisomerases and their roles in genome stability and organization - Nature Reviews Molecular Cell Biology - 2 year(s) ago
Topoisomerases have essential roles in transcription, DNA replication, chromatin remodelling and, as recently revealed, 3D genome organization. However, topoisomerases also generate DNA–protein crosslinks coupled with DNA breaks, which are increasingly recognized as a source of disease-causing genomic damage.
Source: NatureCategories: Allergy-Immunology, Latest HeadlinesTweet
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Mashup Score: 2Molecular Profiling of Exceptional Responders to Cancer Therapy - 3 year(s) ago
The Oncologist is committed to helping physicians excel in the constantly changing fields of oncology and hematology through the publication of timely reviews, original studies, and commentaries on important developments.
Source: The OncologistCategories: Hem/Onc News and Journals, Latest HeadlinesTweet
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Mashup Score: 0Genomic destabilization and its associated mutagenesis increase with senescence‐associated phenotype expression - 3 year(s) ago
Genomic destabilization risk is elevated in association with cellular senescence. Genomic destabilization is associated with mutagenesis. Genomic destabilization induces clonal evolution of cells wit…
Source: Wiley Online LibraryCategories: General Medicine Journals and Societies, Latest HeadlinesTweet
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Mashup Score: 3The regulation and functions of DNA and RNA G-quadruplexes - 4 year(s) ago
G-quadruplexes (G4s) are structures formed in guanine-rich DNA or RNA, which are linked to transcription, translation, chromatin biology, genome instability and RNA modifications. Recent studies connect G4 formation with cancer-cell lethality and indicate that G4s could be therapeutic targets.
Categories: Allergy-Immunology, Latest HeadlinesTweet
In the April issue of Cancer Discovery— Blocking #GenomicInstability Prevents Acquired Resistance to MAPK Inhibitor Therapy in #Melanoma, by— @pdharanipragada, Xiao Zhang, Gatien Moriceau, Roger Lo et al. https://t.co/d6btd0BBLC @UCLA @dgsomucla https://t.co/dMFWXxRgwQ