-
Mashup Score: 4
Analysis of high-quality, haplotype-resolved primate genomes provides a more complete understanding of lineage-specific, recurrent mutations and structurally divergent regions associated with primate adaptive evolution and human diseases.
Source: www.cell.comCategories: General Medicine News, General Journals & SocietTweet
-
Mashup Score: 5
Analysis of high-quality, haplotype-resolved primate genomes provides a more complete understanding of lineage-specific, recurrent mutations and structurally divergent regions associated with primate adaptive evolution and human diseases.
Source: www.cell.comCategories: General Medicine News, General Journals & SocietTweet
-
Mashup Score: 5
From a genetic perspective, modern humans are best defined as a combination of genetic features of archaic humans where each individual carries most but not necessarily all genetic features. This review examines the genetic features of modern humans, Neandertals, and Denisovans and how gene flow among them affected their physiology.
Source: www.cell.comCategories: General Medicine News, General Journals & SocietTweet
-
Mashup Score: 0
Smita K. Rao, MBBS, MS, et al gave an overview of implementing genetic counseling into oncology practices through telemedicine.
Source: www.cancernetwork.comCategories: General Medicine News, Onc News and JournalsTweet
-
Mashup Score: 0
Original Article from The New England Journal of Medicine — Myostatin Mutation Associated with Gross Muscle Hypertrophy in a Child
Source: www.nejm.orgCategories: General Medicine News, Cardiologists1Tweet
-
Mashup Score: 0Cheryl VerStrate on the Pitfalls of Direct-to-Consumer Genetic Tests - 5 month(s) ago
Cheryl VerStrate, DNP, AGPCNP-BC, OCN, discusses why nurses should be prepared to discuss direct-to-consumer genomic testing with their patients.
Source: www.oncnursingnews.comCategories: Hem/Onc News and Journals, Latest HeadlinesTweet
-
Mashup Score: 0A Polygenic Risk Score for Idiopathic Pulmonary Fibrosis and Interstitial Lung Abnormalities - 5 month(s) ago
Rationale: In addition to rare genetic variants and the MUC5B locus, common genetic variants contribute to idiopathic pulmonary fibrosis (IPF) risk. The predictive power of common variants outside …
Source: www.atsjournals.orgCategories: Latest Headlines, RheumatologyTweet-
#BWHRheumatology studied role of common genetic variants in identifying idiopathic pulmonary fibrosis (IPF) and interstitial lung abnormalities (ILA) risk. Polygenic risk scores (PRS) w/o MUC5B region associated w/ IPF, ILA, and ILA progression. https://t.co/3DUSXZnU4I #genetics https://t.co/Aaloi2FmBx
-
-
Mashup Score: 1
In a study reported in JAMA Oncology, Darst et al identified germline genetic variants that were associated with increased risk of aggressive vs nonaggressive prostate cancer. As stated by the investigators, “Germline gene panel testing is recommended for men with advanced prostate cancer or a family history of cancer. While evidence is limited for some genes currently included in panel testing, gene panels are also likely to be incomplete and missing genes that influence p rostate cancer risk and
Source: ascopost.comCategories: Hem/Onc News and Journals, Latest HeadlinesTweet
-
Mashup Score: 0Xiuning Le MD PhD on Update on the Use of Tepotinib to Treat an NSCLC Subset - The ASCO Post - 6 month(s) ago
Xiuning Le, MD, PhD, of The University of Texas MD Anderson Cancer Center, discusses resul ts of the VISION trial, the largest on-treatment liquid biopsy biomarker data set of a MET inhibitor in patients with MET exon 14 non–small cell lung cancer (NSCLC). Tepotinib showed durable efficacy in this population. Chee K. Lee, PhD, MBBS, of the University of Sydney, discusses findings of the ILLUMINATE study, which showed d urvalumab and tremelimumab with chemotherapy yielded antitumor activity in patients
Source: ascopost.comCategories: Hem/Onc News and Journals, Latest HeadlinesTweet
-
Mashup Score: 0Evidence of a genetic background predisposing to complex regional pain syndrome type 1 - 6 month(s) ago
Background Complex regional pain syndrome type 1 (CRPS-1) is a rare, disabling and sometimes chronic disorder usually arising after a trauma. This exploratory study examined whether patients with chronic CRPS-1 have a different genetic profile compared with those who do not have the condition. Methods Exome sequencing was performed to seek altered non-synonymous SNP allele frequencies in a discovery cohort of well-characterised patients with chronic CRPS-1 (n = 34) compared with population databases. Identified SNP alleles were confirmed by Sanger sequencing and sought in a replication cohort (n = 50). Gene expression of peripheral blood macrophages was assessed. Results In the discovery cohort, the rare allele frequencies of four non-synonymous SNPs were statistically increased. The replication cohort confirmed this finding. In a chronic pain cohort, these alleles were not overexpressed. In total, 25 out of 84 (29.8%) patients with CRPS-1 expressed a rare allele. The SNPs were rs41289
Source: jmg.bmj.comCategories: General Medicine Journals and Societies, Latest HeadlinesTweet
To learn more, read the Perspective from @EichlerEE @UWMedicine & colleagues in the new anniversary focus issue on #Genetics: https://t.co/UTS7sLMeFB