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    In a study reported in JAMA Oncology, Darst et al identified germline genetic variants that were associated with increased risk of aggressive vs nonaggressive prostate cancer. As stated by the investigators, “Germline gene panel testing is recommended for men with advanced prostate cancer or a family history of cancer. While evidence is limited for some genes currently included in panel testing, gene panels are also likely to be incomplete and missing genes that influence p rostate cancer risk and

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    • Germline Variants and Risk of Aggressive Prostate Cancer https://t.co/t2u30nfjRv #pcsm #prostatecancer #oncology #genetics

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    Xiuning Le, MD, PhD, of The University of Texas MD Anderson Cancer Center, discusses resul ts of the VISION trial, the largest on-treatment liquid biopsy biomarker data set of a MET inhibitor in patients with MET exon 14 non–small cell lung cancer (NSCLC). Tepotinib showed durable efficacy in this population. Chee K. Lee, PhD, MBBS, of the University of Sydney, discusses findings of the ILLUMINATE study, which showed d urvalumab and tremelimumab with chemotherapy yielded antitumor activity in patients

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    • Xiuning Le, MD, PhD, on Update on the Use of Tepotinib to Treat an NSCLC Subset https://t.co/gnDhcSPbkt #LCSM #lungcancer #WCLC23 #genetics @MDAndersonNews @LeXiuning

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    Background Complex regional pain syndrome type 1 (CRPS-1) is a rare, disabling and sometimes chronic disorder usually arising after a trauma. This exploratory study examined whether patients with chronic CRPS-1 have a different genetic profile compared with those who do not have the condition. Methods Exome sequencing was performed to seek altered non-synonymous SNP allele frequencies in a discovery cohort of well-characterised patients with chronic CRPS-1 (n = 34) compared with population databases. Identified SNP alleles were confirmed by Sanger sequencing and sought in a replication cohort (n = 50). Gene expression of peripheral blood macrophages was assessed. Results In the discovery cohort, the rare allele frequencies of four non-synonymous SNPs were statistically increased. The replication cohort confirmed this finding. In a chronic pain cohort, these alleles were not overexpressed. In total, 25 out of 84 (29.8%) patients with CRPS-1 expressed a rare allele. The SNPs were rs41289

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    • New study in @JMG_BMJ: Genes linked to 1 in 3 cases of complex regional pain syndrome (CRPS) 🧬 Surprisingly, men carry more genetic variants but are less likely to develop syndrome. #CRPS #Genetics #PainResearch Read full article here: https://t.co/a8ahAEyaCW