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Mashup Score: 0Inhibition of VEGF-B signaling prevents non-alcoholic fatty liver disease development by targeting lipolysis in the white adipose tissue - 1 year(s) ago
Hepatosteatosis is a hallmark of Non-alcoholic fatty liver disease (NAFLD), a common co-morbidity in Type 2 diabetes (T2DM). The pathogenesis of NAFLD is complex and involves the crosstalk between the liver and the white adipose tissues (WAT). Vascular Endothelial Growth Factor B (VEGF-B) has been described to control tissue lipid accumulation by regulating the transport properties of the…
Source: Journal of HepatologyCategories: Gastroenterology, Latest HeadlinesTweet
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Mashup Score: 0Targeting m6A reader YTHDF1 augments antitumour immunity and boosts anti-PD-1 efficacy in colorectal cancer - 1 year(s) ago
Objective The role of N6-methyladenosine (m6A) in tumour immune microenvironment (TIME) remains understudied. Here, we elucidate function and mechanism of YTH N6-methyladenosine RNA binding protein 1 (YTHDF1) in colorectal cancer (CRC) TIME. Design Clinical significance of YTHDF1 was assessed in tissue microarrays (N=408) and TCGA (N=526) cohorts. YTHDF1 function was determined in syngeneic…
Source: GutCategories: Gastroenterology, Latest HeadlinesTweet
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Mashup Score: 0The antitumour effects of caloric restriction are mediated by the gut microbiome - Nature Metabolism - 1 year(s) ago
The authors show that caloric restriction increases the intestinal abundance of Bifidobacterium bifidum, which in turn blunts tumour development in mice.
Source: NatureCategories: Gastroenterology, Latest HeadlinesTweet
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Mashup Score: 0Gut microbiota promote liver regeneration through hepatic membrane phospholipid biosynthesis - 1 year(s) ago
Hepatocyte growth and proliferation depends on membrane phospholipid biosynthesis. Short chain fatty acids (SCFA) generated by bacterial fermentation, delivered through the gut-liver axis, significantly contribute to lipid biosynthesis. We therefore hypothesized that dysbiotic insults like antibiotics treatment not only affect gut microbiota, but also impair hepatic lipid synthesis and liver…
Source: Journal of HepatologyCategories: Gastroenterology, Latest HeadlinesTweet
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Mashup Score: 0HK1 from hepatic stellate cell–derived extracellular vesicles promotes progression of hepatocellular carcinoma - Nature Metabolism - 2 year(s) ago
Hexokinase 1 is found to be secreted from hepatic stellate cells in large extracellular vesicles in response to TGF-β, and is subsequently taken up by hepatocellular carcinoma cells, where it promotes tumor progression and metastasis.
Source: NatureCategories: Gastroenterology, Latest HeadlinesTweet
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Mashup Score: 0Molecular characterization of colorectal cancer related peritoneal metastatic disease - Nature Communications - 2 year(s) ago
Colorectal cancer can lead to the development of peritoneal metastases, which are associated with worse disease outcome. Here, the authors characterize peritoneal metastases from 52 patients using RNA-seq and mutational sequencing and show a distinct molecular subtype.
Source: NatureCategories: Gastroenterology, Latest HeadlinesTweet
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Mashup Score: 0The rising burden of inflammatory bowel disease in Denmark over two decades: a nationwide cohort study - 2 year(s) ago
Shifts in epidemiological stages of inflammatory bowel disease (IBD) carry implications towards understanding IBD etiology and managing clinical care. We conducted a temporal analysis of the epidemiology of IBD between 1995 and 2016 in the Danish nationwide cohort.
Source: GastroenterologyCategories: Gastroenterology, Latest HeadlinesTweet
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Mashup Score: 0A critical role of the mechanosensor PIEZO1 in glucose-induced insulin secretion in pancreatic β-cells - Nature Communications - 2 year(s) ago
Insulin secretion depends on action potential firing in pancreatic islet beta-cells, but the underlying mechanism is unclear. Here, the authors show that activation of the mechanosensor ion channel PIEZO1 plays a central role in beta-cell electrical activity and insulin release.
Source: NatureCategories: Gastroenterology, Latest HeadlinesTweet
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Mashup Score: 0
The BMP inhibitor GREM1 is a key regulator of cellular heterogeneity in pancreatic cancer in human and mouse.
Source: NatureCategories: Gastroenterology, Latest HeadlinesTweet
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Mashup Score: 0
NeuroString, a tissue-like biological interface created by laser patterning of polyimide into a graphene/nanoparticle network embedded in an elastomer, is introduced, allowing in vivo real-time detection of neurotransmitters in the brain and gut.
Source: NatureCategories: Gastroenterology, Latest HeadlinesTweet
#GastroEdPick Data from mouse models indicate that VEGFB antagonism reduced #NAFLD in diabetic mice by suppressing lipolysis in white adipose tissue. In biopsies from pts with NAFLD, VEGFB signalling was upregulated in white adipose tissue @JHepatology https://t.co/T6Ma6K3oAZ