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    Objective The role of N6-methyladenosine (m6A) in tumour immune microenvironment (TIME) remains understudied. Here, we elucidate function and mechanism of YTH N6-methyladenosine RNA binding protein 1 (YTHDF1) in colorectal cancer (CRC) TIME. Design Clinical significance of YTHDF1 was assessed in tissue microarrays (N=408) and TCGA (N=526) cohorts. YTHDF1 function was determined in syngeneic…

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    • #GastroEdPick A new study explores the role of YTHDF1 (YTH N6-methyladenosine RNA binding protein 1) in CRC anti-tumour immunity @Gut_BMJ https://t.co/oSNo2OnIpa

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    Hepatocyte growth and proliferation depends on membrane phospholipid biosynthesis. Short chain fatty acids (SCFA) generated by bacterial fermentation, delivered through the gut-liver axis, significantly contribute to lipid biosynthesis. We therefore hypothesized that dysbiotic insults like antibiotics treatment not only affect gut microbiota, but also impair hepatic lipid synthesis and liver…

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    • #GastroEdPick Researchers have investigated the role of the #gutmicrobiota in hepatic membrane phospholipid biosynthesis and liver regeneration in mice @JHepatology https://t.co/i4sLsnCWxy

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    NeuroString, a tissue-like biological interface created by laser patterning of polyimide into a graphene/nanoparticle network embedded in an elastomer, is introduced, allowing in vivo real-time detection of neurotransmitters in the brain and gut.

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    • #GastroEdPick A study reports a tissue-like neurotransmitter sensor for the mouse brain and gut – to enable real-time monitoring of monoamine dynamics in both tissues @Nature https://t.co/Pr0la9GdHO