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Mashup Score: 14Tumor and Peritoneum-Associated Macrophage Gene Signature as a Novel Molecular Biomarker in Gastric Cancer - 10 day(s) ago
A spectrum of immune states resulting from tumor resident macrophages and T-lymphocytes in the solid tumor microenvironment correlates with patient outcomes. We hypothesized that in gastric cancer (GC), macrophages in a polarized immunosuppressive transcriptional state would be prognostic of poor survival. We derived transcriptomic signatures for M2 (M2TS, MRC1; MS4A4A; CD36; CCL13; CCL18; CCL23; SLC38A6; FGL2; FN1; MAF) and M1 (M1TS, CCR7; IL2RA; CXCL11; CCL19; CXCL10; PLA1A; PTX3) macrophages, and cytolytic T-lymphocytes (CTLTS, GZMA; GZMB; GZMH; GZMM; PRF1). Primary GC in a TCGA stomach cancer dataset was evaluated for signature expressions, and a log-rank test determined overall survival (OS) and the disease-free interval (DFI). In 341 TCGA GC entries, high M2TS expression was associated with histological types and later stages. Low M2TS expression was associated with significantly better 5-year OS and DFI. We validated M2TS in prospectively collected peritoneal fluid of a GC patie
Source: www.mdpi.comCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 18
VYLOY approved in combination with chemotherapy for patients with human epidermal growth factor receptor 2 (HER2)-negative, CLDN18.2 positive, unresectable, advanced or recurrent gastric cancer…
Source: newsroom.astellas.usCategories: General Medicine News, PayerTweet
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Mashup Score: 0GI Cancer Chronicles - 1 month(s) ago
Navigating a gastric cancer diagnosis? Hear from those who have been through it. Information on gastric cancer, also known as stomach cancer, can be complicated and overwhelming, making it difficult to answer the question, “What now?”. GI Cancer Chronicles aims to help answer this question and more through the stories of people who experience gastric cancer from different lenses. Through these stories, we’re diving deeper into questions like, “What are biomarkers?”, “How can I advocate for myself during treatment decision-making?” and “How can I be the best version of a caregiver?”. Our hope is that these raw, real conversations help you feel educated and empowered to take on your personal gastric cancer journey, no matter your role. This channel is intended for U.S. residents only. The information provided is for educational purposes and is not intended to replace discussions with a healthcare provider. ©2023 Astellas Pharma US, Inc. All rights reserved. 074-1139-PM 11/2023.
Source: www.youtube.comCategories: General Medicine News, PayerTweet
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Mashup Score: 0GI Cancer Chronicles - 2 month(s) ago
Navigating a gastric cancer diagnosis? Hear from those who have been through it. Information on gastric cancer, also known as stomach cancer, can be complicated and overwhelming, making it difficult to answer the question, “What now?”. GI Cancer Chronicles aims to help answer this question and more through the stories of people who experience gastric cancer from different lenses. Through these stories, we’re diving deeper into questions like, “What are biomarkers?”, “How can I advocate for myself during treatment decision-making?” and “How can I be the best version of a caregiver?”. Our hope is that these raw, real conversations help you feel educated and empowered to take on your personal gastric cancer journey, no matter your role. This channel is intended for U.S. residents only. The information provided is for educational purposes and is not intended to replace discussions with a healthcare provider. ©2023 Astellas Pharma US, Inc. All rights reserved. 074-1139-PM 11/2023.
Source: www.youtube.comCategories: General Medicine News, PayerTweet
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Mashup Score: 1First Patient Dosed With Drug Combo in Phase 2 Gastric Cancer Trial - 2 month(s) ago
A patient in a phase 2 trial has received the first dose of a novel combination of botensilimab and balstilimab plus agenT-979, an allogeneic cell therapy.
Source: www.curetoday.comCategories: General Medicine News, NursingTweet
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Mashup Score: 0Second-Line Fruquintinib Plus Paclitaxel Improves PFS But Not OS in Advanced Gastric or GEJ Adenocarcinoma - 2 month(s) ago
Fruquintinib/paclitaxel significantly improved PFS but not OS vs paclitaxel alone in the second-line treatment in patients with advanced gastric cancer.
Source: www.onclive.comCategories: General Medicine News, Onc News and JournalsTweet
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Mashup Score: 0Second-Line Fruquintinib Plus Paclitaxel Improves PFS But Not OS in Advanced Gastric or GEJ Adenocarcinoma - 2 month(s) ago
Fruquintinib/paclitaxel significantly improved PFS but not OS vs paclitaxel alone in the second-line treatment in patients with advanced gastric cancer.
Source: www.onclive.comCategories: General Medicine News, Onc News and JournalsTweet
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Mashup Score: 0Second-Line Fruquintinib Plus Paclitaxel Improves PFS But Not OS in Advanced Gastric or GEJ Adenocarcinoma - 3 month(s) ago
Fruquintinib/paclitaxel significantly improved PFS but not OS vs paclitaxel alone in the second-line treatment in patients with advanced gastric cancer.
Source: www.onclive.comCategories: General Medicine News, Onc News and JournalsTweet
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Mashup Score: 0Development of a tongue image-based machine learning tool for the diagnosis of gastric cancer: a prospective multicentre clinical cohort study - 3 month(s) ago
Our results suggest that tongue images can be used as a stable method for GC diagnosis and are significantly superior to conventional blood biomarkers. The three kinds of tongue image-based AI deep learning diagnostic models that we developed can be used to adequately distinguish patients with GC from participants with NGC, even early GC and precancerous lesions, such as atrophic gastritis (AG).
Source: www.thelancet.comCategories: General Medicine News, General HCPsTweet-
@DrCMJones @RFitzgerald_lab @EarlyCancerCam @CRUK_CI @CR_UK @The_OIRO @HPBCambridge Cohort study: Development of a tongue image-based machine learning tool for diagnosis of #GastricCancer Results suggest that tongue images can be used as a stable method for gastric cancer diagnosis and are superior to conventional blood biomarkers https://t.co/vYSx51QeMI 6/9 https://t.co/oNzms71845
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Mashup Score: 7Zolbetuximab for Claudin18.2-positive gastric or gastroesophageal junction cancer - Yohei Kubota, Kohei Shitara, 2024 - 3 month(s) ago
Claudins (CLDNs) are a family of major membrane proteins that form components of tight junctions. In normal tissues, CLDNs seal the intercellular space in the e…
Source: journals.sagepub.comCategories: General Medicine News, Hem/OncsTweet
Nice paper from @Yanghee61217641's group at @cityofhope defining a tumor/peritoneum-associated macrophage gene signature associated with outcome in #gastriccancer - full paper in @IJMS_MDPI here: https://t.co/LJlU0a0AMt https://t.co/3c6ced5Jd3