• Mashup Score: 232
    Unveiling TMEM106B: SARS-CoV-2’s secret entrance to the cell - 9 month(s) ago

    The lysosomal membrane protein TMEM106B functions as a proviral factor in SARS-CoV-2 infection, though it was not known how. In this issue of Cell, Baggen et al. demonstrate that TMEM106B serves as an ACE2-independent receptor for SARS-CoV-2 entry by promoting the fusion of the viral membrane with the lysosomal membrane.

    Source: www.cell.com
    Categories: Expert Picks, Latest Headlines
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      EricTopol

      The "secret entrance" for #SARSCoV2 to get into cells https://t.co/4Lx0NYdBYs the lysosomal membrane protein (TMEM106B) is tightly linked to #FTD and brain aging disorders @CellCellPress @AlexanderLacra6 @fenghua_hu https://t.co/inglLZVtRC

  • Mashup Score: 1
    Bruce Willis' Dementia Is Not Your Grandpa's Dementia - 1 year(s) ago

    A neuroscientist reviews how FTD differs from more common forms of dementia with little initial impact on a patient’s broader memory and associated cognitive abilities.

    Source: Medscape
    Categories: Healthcare Professionals, Latest Headlines
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      westr

      Bruce Willis' #Dementia Is Not Your Grandpa's Dementia https://t.co/vawEJrlX9r via @medscape #Alzheimer #FTD Great commentary by accomplished @UCSF #Neuroscientist, Michael Merzenich, PhD

  • Mashup Score: 0
    Frontotemporal dementia presentation in patients with heterozygous p.H157Y variant of TREM2 - 1 year(s) ago

    Background The triggering receptor expressed on myeloid cell 2 (TREM2) is a major regulator of neuroinflammatory processes in neurodegeneration. To date, the p.H157Y variant of TREM2 has been reported only in patients with Alzheimer’s disease. Here, we report three patients with frontotemporal dementia (FTD) from three unrelated families with heterozygous p.H157Y variant of TREM2 : two patients…

    Source: Journal of Medical Genetics
    Categories: General Medicine Journals and Societies, Latest Headlines
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      JMG_BMJ

      #TREM2 H157Y (known in familial #Alzheimers) Also now #frontotemporalDementia (#FTD) 🧠 @AgustinMIbanez report 3 unrelated families, highlights phenotypic variability - https://t.co/cqzCJGlLft @BrainlatUAI @CNCUdeSA @Neuro_Colombia @GeneticaPUJ #Dementia #EndFTD https://t.co/MOrY9E0oLO

  • Mashup Score: 14
    Towards Better Management of Disinhibition in Frontotemporal Dementia - Neuroscience News - 1 year(s) ago

    People with behavioral variant frontotemporal dementia (bvFTD) exhibit behaviors that are considered socially unacceptable. While there is no current cure for FTD, researchers are finding methods to help inhibit some of the negative behaviors associated with FTD. A new study reports impulsivity and negative behaviors are greatly reduced in those with bvFTD when the patient is focused on a task.

    Source: Neuroscience News
    Categories: Latest Headlines, Neurology
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      NeuroscienceNew

      Towards Better Management of Disinhibition in Frontotemporal Dementia A new study reports impulsivity and negative behaviors are greatly reduced in those with bvFTD when the patient is focused on a task. #ftd #neuroscience #science https://t.co/sUNtsUPhNB

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