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Mashup Score: 4Spatial Transcriptomics Depict Ligand–Receptor Cross-talk Heterogeneity at the Tumor-Stroma Interface in Long-Term Ovarian Cancer Survivors - 11 month(s) ago
Generation of spatially resolved gene expression patterns in tumors from patients with ovarian cancer surviving more than 10 years allows the identification of novel predictive biomarkers and therapeutic targets for better patient management.
Categories: Hem/Onc News and Journals, Latest HeadlinesTweet
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Mashup Score: 3The Journal of Immunology - 1 year(s) ago
Read Volume 210 Issue 2 of The Journal of Immunology.
Categories: Allergy-Immunology, Latest HeadlinesTweet-
Congratulations to Jessy Alexander @UBuffalo on their cover image: in vitro invasion of #RheumatoidArthritis #fibroblast-like #synoviocytes, which were infected with HAFML overexpression lentivirus 👉https://t.co/j3YYVyTatx https://t.co/nQcAAXBuR5
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Mashup Score: 2Eplerenone Improves Pulmonary Vascular Remodeling and Hypertension by Inhibition of the Mineralocorticoid Receptor in Endothelial Cells - 3 year(s) ago
Pulmonary hypertension is characterized by progressive remodeling of the pulmonary arteries, however, this is not therapeutically targeted yet. Aldosterone and the MR (mineralocorticoid receptor) are
Source: HypertensionCategories: Cardiology News and Journals, Latest HeadlinesTweet-
Eplerenone improves vascular remodeling and #PH by inhibiting the mineralocorticoid receptor in #endothelial cells, independent from MR in #VSMC, #fibroblast, or #macrophage. @AchimLother https://t.co/QcmaFVCA09 https://t.co/tREMLdAk2C
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Mashup Score: 3
Rationale: Cardiomyopathy is characterized by the deposition of extracellular matrix by activated resident cardiac fibroblasts called myofibroblasts. There are currently no therapeutic approaches to
Source: Circulation ResearchCategories: Cardiology News and Journals, Latest HeadlinesTweet-
Burke & colleagues found that the polyether ionophore #salinomycin blocks pathological #CardiacRemodeling following #ischemic and non-ischemic injury. Learn more about how salinomycin prevents #fibroblast activation at https://t.co/bvD4nDBDfv @Eric66867284 https://t.co/ngBVqgq8Ku
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Mashup Score: 0Fibroblast cells reveal their ancestry - 3 year(s) ago
Cellular lineages of fibroblast cells in different organs revealed.
Source: www.nature.comCategories: Healthcare Professionals, Latest HeadlinesTweet-
#Fibroblast cells reveal their ancestry https://t.co/MKJ24q8ZIe
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Mashup Score: 11Netrin G1 Promotes Pancreatic Tumorigenesis through Cancer-Associated Fibroblast–Driven Nutritional Support and Immunosuppression - 3 year(s) ago
Pancreatic ductal adenocarcinoma (PDAC) has a poor 5-year survival rate and lacks effective therapeutics. Therefore, it is of paramount importance to identify new targets. Using multiplex data from patient tissue, three-dimensional coculturing in vitro assays, and orthotopic murine models, we identified Netrin G1 (NetG1) as a promoter of PDAC tumorigenesis. We found that NetG1+ cancer-associated…
Source: Cancer DiscoveryCategories: Hem/Onc News and Journals, Latest HeadlinesTweet-
In the #AACR21 “Puppet Master Cells” Minisymposium on Ch. 5, @DebVendramini discusses work published in @CD_AACR showing Netrin G1 promotes #PancreaticCancer through cancer associated #fibroblast–driven nutritional support and immunosuppression. https://t.co/vKjag2GhG3 https://t.co/Cm66z03JEl
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Mashup Score: 2Cancer-associated fibroblast secretion of PDGFC promotes gastrointestinal stromal tumor growth and metastasis - 3 year(s) ago
Targeted therapies for gastrointestinal stromal tumor (GIST) are modestly effective, but GIST cannot be cured with single agent tyrosine kinase inhibitors. In this study, we sought to identify new therapeutic targets in GIST by investigating the tumor microenvironment. Here, we identified a paracrine signaling network by which cancer-associated fibroblasts (CAFs) drive GIST growth and metastasis….
Source: OncogeneCategories: Hem/Onc News and Journals, Latest HeadlinesTweet-
A study by @JasonSicklick lab shows new way of cell-to-cell signalling in #gastrointestinal stromal tumours which promotes growth and metastasis. Read now in @oncogenejournal. #cancer #fibroblast #therapy @UCSDsurgery https://t.co/0V5eMkYJ3Q
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Mashup Score: 3
Older patients with melanoma (>50 years old) have poorer prognoses and response rates to targeted therapy compared with young patients (<50 years old), which can be driven, in part, by the aged microenvironment. Here, we show that aged dermal fibroblasts increase the secretion of neutral lipids, especially ceramides. When melanoma cells are exposed to the aged fibroblast lipid secretome, or...
Source: Cancer DiscoveryCategories: Hem/Onc News and Journals, Latest HeadlinesTweet-
We're watching Ashani T. Weeraratna present at #AACRtme21. ICYMI: Changes in aged #fibroblast lipid #metabolism induce age-dependent #melanoma cell resistance to #TargetedTherapy via the fatty acid transporter FATP2. #Aging @gretchen_alicea @AshaniTW https://t.co/hJ8lcfFahd https://t.co/TizCjl1ESI
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Mashup Score: 5Infarct Collagen Topography Regulates Fibroblast Fate via p38-Yes-Associated Protein Transcriptional Enhanced Associate Domain Signals - 4 year(s) ago
Rationale: Myocardial infarction causes spatial variation in collagen organization and phenotypic diversity in fibroblasts, which regulate the heart’s ECM (extracellular matrix). The relationship bet
Source: Circulation ResearchCategories: Cardiology News and Journals, Latest HeadlinesTweet-
Bugg & colleagues demonstrate that aligned #collagen in #MyocardialInfarction induces #p38, #YAP, & #TEAD interactions & these signals are required for #cardiac #fibroblast to #myofibroblast transitions. https://t.co/mf9n0JpA2l @rossbreth @kellystevenslab @JD98119 https://t.co/4obhdCWugs
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Mashup Score: 0Single-Cell Analysis Reveals Fibroblast Clusters Linked to Immunotherapy Resistance in Cancer - 4 year(s) ago
A subset of cancer-associated fibroblasts (FAP+/CAF-S1) mediates immunosuppression in breast cancers, but its heterogeneity and its impact on immunotherapy response remain unknown. Here, we identify 8 CAF-S1 clusters by analyzing more than 19,000 single CAF-S1 fibroblasts from breast cancer. We validate the five most abundant clusters by flow cytometry and in silico analyses in other cancer…
Source: Cancer DiscoveryCategories: Hem/Onc News and Journals, Latest HeadlinesTweet-
In recognition of #BreastCancerAwareness Month: #SingleCell analysis reveals #fibroblast clusters linked to #immunotherapy resistance in #cancer. @institut_curie @FatimaMechta https://t.co/sSIqaMfYWs https://t.co/RI9JFtvQIZ
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Spatial transcriptomics and scRNA-seq were integrated to generate and compare spatially resolved profiles of #ovariancancer from LTS and STS and to establish the association between cancer-associated #fibroblast heterogeneity and survival in patients. https://t.co/UDYkD38o3O https://t.co/8oqIqrxZb2