• Mashup Score: 2

    Cancer-related fatigue (CRF) is one of the most common complications in patients with multiple cancer types and severely affects patients’ quality of life. However, there have only been single symptom-relieving adjuvant therapies but no effective pharmaceutical treatment for the CRF syndrome. Dichloroacetate (DCA), a small molecule inhibitor of pyruvate dehydrogenase kinase, has been tested as a potential therapy to slow tumor growth, based largely on its effects in vitro to halt cell division. We found that although DCA did not affect rates of tumor growth or the efficacy of standard cancer treatment (immunotherapy and chemotherapy) in two murine cancer models, DCA preserved physical function in mice with late-stage tumors by reducing circulating lactate concentrations. In vivo liquid chromatography-mass spectrometry/mass spectrometry studies suggest that DCA treatment may preserve membrane potential, postpone proteolysis, and relieve oxidative stress in muscles of tumor-bearing mice.

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    • Team reports on promising treatment for cancer-related #fatigue @yale https://t.co/tCtoamx3jR https://t.co/PtSKDlX9qD

  • Mashup Score: 0

    Explore the importance of exercise and managing fatigue. Learn when to push through and when to consult your doctor.

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    • Exercising with arthritis can lower #pain and #fatigue, and improve functionality and mental health. On the other hand, you may feel so fatigued that the thought of #exercise feels out-of-reach. Learn when to push through and when to consult your doctor: https://t.co/sUIVMOGyx0

  • Mashup Score: 3

    Fatigue is among the top 10 reasons patients visit primary care offices, and it significantly affects patients’ well-being and occupational safety. A comprehensive history and cardiopulmonary, neurologic, and skin examinations help guide the workup and diagnosis. Fatigue can be classified as physiologic, secondary, or chronic. Physiologic fatigue can be addressed by proper sleep hygiene, a healthy diet, and balancing energy expenditure. Secondary fatigue is improved by treating the underlying condition. Cognitive behavior therapy, exercise therapy, and acupuncture may help with some of the fatigue associated with chronic conditions. Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a chronic, severe, and potentially debilitating disorder with demonstrated inflammatory, neurologic, immunologic, and metabolic abnormalities. ME/CFS has a poor prognosis, with no proven treatment or cure. It may become more common after the COVID-19 pandemic because many patients with long COVI

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    • Fatigue is a common symptom in older adults. It can be hard to differentiate between normal aging and a more serious underlying condition. Read this article for tips on evaluation and management in primary care: https://t.co/KN0WCJwREA #medtwitter #familymedicine #fatigue https://t.co/kvXkZFvsw8

  • Mashup Score: 2

    Introducing Spondycast, SAA’s new podcast series, that provides the newest and most exciting source of information and inspiration for people with spondyloarthritis. Every week, we bring you in-depth conversations with the leading experts in the field, who will share their knowledge and experience on topics related to the diagnosis, treatment, and management of this complex disease. Whether you…

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    • Tune in to the latest episode of #Spondycast, hosted by Jill Miller, as she speaks with Pediatric rheumatologist, Matthew Stoll, who will discuss the diagnosis of juvenile #spondyloarthritis. Tune in now https://t.co/2j7Kx7aagj #fatigue #JuvenileArthritisawarenessmonth https://t.co/pXjAsQzCCN