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Mashup Score: 0Fluorescence-tagged salivary small extracellular vesicles as a nanotool in early diagnosis of Parkinson’s disease - BMC Medicine - 7 month(s) ago
Background Parkinson’s disease is generally asymptomatic at earlier stages. At an early stage, there is an extensive progression in the neuropathological hallmarks, although, at this stage, diagnosis is not possible with currently available diagnostic methods. Therefore, the pressing need is for susceptibility risk biomarkers that can aid in better diagnosis and therapeutics as well can objectively serve to measure the endpoint of disease progression. The role of small extracellular vesicles (sEV) in the progression of neurodegenerative diseases could be potent in playing a revolutionary role in biomarker discovery. Methods In our study, the salivary sEV were efficiently isolated by chemical precipitation combined with ultrafiltration from subjects (PD = 70, healthy controls = 26, and prodromal PD = 08), followed by antibody-based validation with CD63, CD9, GAPDH, Flotillin-1, and L1CAM. Morphological characterization of the isolated sEV through transmission electron microscopy. The qu
Source: bmcmedicine.biomedcentral.comCategories: General Medicine Journals and Societies, Latest HeadlinesTweet
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Mashup Score: 0Extracellular vesicles and nanoparticles: emerging complexities - 1 year(s) ago
Cells communicate with each other by secreting signaling molecules, including proteins, lipids, and nucleic acids. Cells can package these signaling molecules in EVs (see Glossary) in an effort to avoid rapid degradation and escape immune surveillance, among other purposes, resulting in local and long-distance intercellular communication. EVs are lipid-bilayer membrane-enclosed vesicles that are…
Source: Trends in Cell BiologyCategories: Hem/Oncs, Latest HeadlinesTweet
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Mashup Score: 1Lipopolysaccharide Primes Human Macrophages for Noncanonical Inflammasome-Induced Extracellular Vesicle Secretion - 1 year(s) ago
Key Points. Noncanonical inflammasome activation triggers release of extracellular vesicles.This EV secretion is caspase-4–, NLRP3- and type I IFN–dependent.PGJ
Categories: Allergy-Immunology, Latest HeadlinesTweet
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Mashup Score: 3Nicotine exacerbates endothelial dysfunction and drives atherosclerosis via extracellular vesicle-miRNA - 1 year(s) ago
AbstractAims. Nicotine, a major component of tobacco, is an important factor contributing to atherosclerosis. However, the molecular mechanisms underlying the l
Source: OUP AcademicCategories: Cardiology News and Journals, Latest HeadlinesTweet
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Mashup Score: 0Ovarian Cancer Midwest Focus - 1 year(s) ago
Maria Barbolina, PhD, from the University of Illinois Cancer Center, presenting on Microtubules (MTs) and their Dynamics in Chemo-Resistant Ovarian Cancer. Ron Buckanovich, MD, PhD, from the Magee-Womens Research Institute, presenting on Ovarian Cancer Models: A Humanized Model of Ovarian Cancer. Uri Ben-David, PhD, from the Tel Aviv University, presenting on Aneuploidy in Cancer and in…
Categories: Hem/Oncs, Latest HeadlinesTweet
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Mashup Score: 0
Background Tunneling nanotubes (TNTs) are naturally-occurring filamentous actin-based membranous extensions that form across a wide spectrum of mammalian cell types to facilitate long-range intercellular communication. Valid assays are needed to accurately assess the downstream effects of TNT-mediated transfer of cellular signals in vitro. We recently reported a modified transwell assay system…
Source: SpringerLinkCategories: Hem/Oncs, Latest HeadlinesTweet
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Mashup Score: 4
Welcome! You are invited to join a webinar: Frontiers in Cardiovascular Science Seminar. After registering, you will receive a confirmation email about joining the webinar.
Source: Zoom Video CommunicationsCategories: Cardiologists, Latest HeadlinesTweet-
Please join @StanfordCVI seminar on Tue 9/27 at 12-1pm PST by Asa Gustafsson @UCSDHealth on #ExtracellularVesicles in #heart. Zoom link: https://t.co/oD1xyw95rv @StanfordDeptMed @StanCVFellows @Stanford_ChEMH @vascularbiology @UCSD_CardioLabs @SeanM_Wu @ECI_ISHR @BCVSearlyCareer https://t.co/RYTfRyZ3i9
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Mashup Score: 3
Exosomes Extracellular Vesicles Liquid Biopsy Circulating Tumour Cells Microfluidics Flow Cytometry Single Cell Analysis
Source: SELECTBIOCategories: Hem/Onc News and Journals, Latest HeadlinesTweet
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Mashup Score: 20The roles of extracellular vesicles in the immune system - Nature Reviews Immunology - 2 year(s) ago
Extracellular vesicles (EVs) are increasingly recognized as having ubiquitous roles in the immune system. This Review focuses on the progress made in the field in the past 5 years, including the roles of EVs in innate and adaptive immunity and their potential use in diagnosis and therapy.
Source: NatureCategories: Allergy-Immunology, Latest HeadlinesTweet
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Mashup Score: 2Wolters Kluwer Health - 2 year(s) ago
JavaScript Error JavaScript has been disabled on your browser. You must enable it to continue. Here’s how to enable JavaScript in the following browsers: Internet Explorer From the Tools menu, select Options Click the Content tab Select Enable JavaScript Firefox From the Tools…
Source: lww.comCategories: Latest Headlines, TransplantationTweet
New research from @aiims_newdelhi finds #Fluorescence-tagged salivary small #extracellularvesicles to have potential in screening the progression of early #Parkinsonsdisease https://t.co/52WIzxWQmT @SimranR61580474 #SarojKumarlab #clinicaldiagnostics #nanotool https://t.co/Qt8NIUxpEy