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    Background Parkinson’s disease is generally asymptomatic at earlier stages. At an early stage, there is an extensive progression in the neuropathological hallmarks, although, at this stage, diagnosis is not possible with currently available diagnostic methods. Therefore, the pressing need is for susceptibility risk biomarkers that can aid in better diagnosis and therapeutics as well can objectively serve to measure the endpoint of disease progression. The role of small extracellular vesicles (sEV) in the progression of neurodegenerative diseases could be potent in playing a revolutionary role in biomarker discovery. Methods In our study, the salivary sEV were efficiently isolated by chemical precipitation combined with ultrafiltration from subjects (PD = 70, healthy controls = 26, and prodromal PD = 08), followed by antibody-based validation with CD63, CD9, GAPDH, Flotillin-1, and L1CAM. Morphological characterization of the isolated sEV through transmission electron microscopy. The qu

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    • New research from @aiims_newdelhi finds #Fluorescence-tagged salivary small #extracellularvesicles to have potential in screening the progression of early #Parkinsonsdisease https://t.co/52WIzxWQmT @SimranR61580474 #SarojKumarlab #clinicaldiagnostics #nanotool https://t.co/Qt8NIUxpEy

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    Cells communicate with each other by secreting signaling molecules, including proteins, lipids, and nucleic acids. Cells can package these signaling molecules in EVs (see Glossary) in an effort to avoid rapid degradation and escape immune surveillance, among other purposes, resulting in local and long-distance intercellular communication. EVs are lipid-bilayer membrane-enclosed vesicles that are…

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    • Good primer in @TrendsCellBio on the increasingly complex and heterogeneous world of extracellular vesicles: don't just call them #exosomes any more! https://t.co/Jt3rwMkUzR #extracellularvesicles #EV #EVs #cellbio https://t.co/YhpYz3Hjqg

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    Maria Barbolina, PhD, from the University of Illinois Cancer Center, presenting on Microtubules (MTs) and their Dynamics in Chemo-Resistant Ovarian Cancer. Ron Buckanovich, MD, PhD, from the Magee-Womens Research Institute, presenting on Ovarian Cancer Models: A Humanized Model of Ovarian Cancer. Uri Ben-David, PhD, from the Tel Aviv University, presenting on Aneuploidy in Cancer and in…

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    • A major theme of the 2022 Ovarian Cancer Midwest Focus Conference is the important role of intercellular communication occurring via #tunnelingnanotubes and #exosomes/#extracellularvesicles #EVs (and it's not just coming from me, I promise!) #OCRF #gyncsm https://t.co/dnWN0t1HSc

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    Extracellular vesicles (EVs) are increasingly recognized as having ubiquitous roles in the immune system. This Review focuses on the progress made in the field in the past 5 years, including the roles of EVs in innate and adaptive immunity and their potential use in diagnosis and therapy.

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    • NEW Review: The roles of extracellular vesicles in the immune system https://t.co/z4VAMCxBcA by @EditBuzas @semmelweishu including roles of #EVs in innate and adaptive immunity, and potential use for diagnosis and therapy #extracellularvesicles #exosomes https://t.co/C9ncJHu1ZF

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    Wolters Kluwer Health - 2 year(s) ago

    JavaScript Error JavaScript has been disabled on your browser. You must enable it to continue. Here’s how to enable JavaScript in the following browsers: Internet Explorer From the Tools menu, select Options Click the Content tab Select Enable JavaScript Firefox From the Tools…

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    • Are #extracellularVesicles the biomarker to assess kidney graft quality is answered in this paper by Woud et al. #VisualAbstract #TransplantTwitter @BaanCarla @RotterdamTrans https://t.co/N18FBax4G5 https://t.co/sydY8SuFtb