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Mashup Score: 9
Background Hematopoietic acute radiation syndrome (H-ARS) occurring after exposure to ionizing radiation damages bone marrow causing cytopenias, increasing susceptibility to infections and death. We and others have shown that cellular therapies like human mesenchymal stromal cells (MSCs), or monocytes/macrophages educated ex-vivo with extracellular vesicles (EVs) from MSCs were effective in a lethal H-ARS mouse model. However, given the complexity of generating cellular therapies and the potential risks of using allogeneic products, development of an “off-the-shelf” cell-free alternative like EVs may have utility in conditions like H-ARS that require rapid deployment of available therapeutics. The purpose of this study was to determine the feasibility of producing MSC-derived EVs at large scale using a bioreactor and assess critical quality control attributes like identity, sterility, and potency in educating monocytes and promoting survival in a lethal H-ARS mouse model. Methods EVs w
Source: stemcellres.biomedcentral.comCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 3Study Sheds Light on Why Wounds Heal Poorly in People with Diabetes - Practical Dermatology - 7 month(s) ago
These insights open the door to new exosome-focused therapies to promote healing of chronic wounds.
Source: practicaldermatology.comCategories: Dermatology, Latest HeadlinesTweet
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Mashup Score: 1Exosomes 101 - Practical Dermatology - 10 month(s) ago
Exosomes are today’s hottest skincare ingredient, and Glynis Ablon, MD, gives viewers the scoop on how and when to use them.
Source: Practical DermatologyCategories: Dermatology, Latest HeadlinesTweet
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Mashup Score: 0Extracellular vesicles and nanoparticles: emerging complexities - 1 year(s) ago
Cells communicate with each other by secreting signaling molecules, including proteins, lipids, and nucleic acids. Cells can package these signaling molecules in EVs (see Glossary) in an effort to avoid rapid degradation and escape immune surveillance, among other purposes, resulting in local and long-distance intercellular communication. EVs are lipid-bilayer membrane-enclosed vesicles that are…
Source: Trends in Cell BiologyCategories: Hem/Oncs, Latest HeadlinesTweet
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Mashup Score: 0
Imatinib is a tyrosine kinase inhibitor that is widely used to combat gastrointestinal stromal tumours (GISTs). However, secondary resistance to imatinib is an important challenge in GIST treatment. Recent studies have demonstrated that cancer-derived nanosized exosomes play a key role in intercellular communication, but little is known about the roles of exosomes in imatinib-resistant GISTs….
Source: NatureCategories: Hem/Onc News and Journals, Latest HeadlinesTweet
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Mashup Score: 0The Multifaceted Role of Connexins in Tumor Microenvironment Initiation and Maintenance - 1 year(s) ago
Today’s research on the processes of carcinogenesis and the vital activity of tumor tissues implies more attention be paid to constituents of the tumor microenvironment and their interactions. These interactions between cells in the tumor microenvironment can be mediated via different types of protein junctions. Connexins are one of the major contributors to intercellular communication. They form…
Source: MDPICategories: Hem/Oncs, Latest HeadlinesTweet
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Mashup Score: 1Day 1 Agenda | LBx Surveillance & Early Detection Summit - 1 year(s) ago
View the agenda to see what’s on over the conference. Find out what sessions, speakers and networking opportunities are set for day one.
Categories: Hem/Oncs, Latest HeadlinesTweet
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Mashup Score: 0Ovarian Cancer Midwest Focus - 1 year(s) ago
Maria Barbolina, PhD, from the University of Illinois Cancer Center, presenting on Microtubules (MTs) and their Dynamics in Chemo-Resistant Ovarian Cancer. Ron Buckanovich, MD, PhD, from the Magee-Womens Research Institute, presenting on Ovarian Cancer Models: A Humanized Model of Ovarian Cancer. Uri Ben-David, PhD, from the Tel Aviv University, presenting on Aneuploidy in Cancer and in…
Categories: Hem/Oncs, Latest HeadlinesTweet
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Mashup Score: 0
Background Tunneling nanotubes (TNTs) are naturally-occurring filamentous actin-based membranous extensions that form across a wide spectrum of mammalian cell types to facilitate long-range intercellular communication. Valid assays are needed to accurately assess the downstream effects of TNT-mediated transfer of cellular signals in vitro. We recently reported a modified transwell assay system…
Source: SpringerLinkCategories: Hem/Oncs, Latest HeadlinesTweet
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Mashup Score: 20The roles of extracellular vesicles in the immune system - Nature Reviews Immunology - 2 year(s) ago
Extracellular vesicles (EVs) are increasingly recognized as having ubiquitous roles in the immune system. This Review focuses on the progress made in the field in the past 5 years, including the roles of EVs in innate and adaptive immunity and their potential use in diagnosis and therapy.
Source: NatureCategories: Allergy-Immunology, Latest HeadlinesTweet
Congrats to John Kink and team @WiscPediatrics @uwsmph @UWCarbone @UWSCRMC @MCWCancerCenter for developing a GMP compliant protocol for generating #exosomes for hematopoietic acute radiation syndrome https://t.co/0oa9adDY4o