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Mashup Score: 0Altered methylation pattern in EXOC4 is associated with stroke outcome: an epigenome-wide association study - Clinical Epigenetics - 2 year(s) ago
Background and purpose The neurological course after stroke is highly variable and is determined by demographic, clinical and genetic factors. However, other heritable factors such as epigenetic DNA methylation could play a role in neurological changes after stroke. Methods We performed a three-stage epigenome-wide association study to evaluate DNA methylation associated with the difference…
Source: BioMed CentralCategories: Future of Medicine, Latest HeadlinesTweet
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Mashup Score: 11
Here, we report a lack of diversity in epigenome-wide association studies (EWAS) and DNA methylation (DNAm) data, discuss current challenges, and propose solutions for EWAS and DNAm research in diverse populations. The strategies we propose include fostering community involvement, new data generation, and cost-effective approaches such as locus-specific analysis and ancestry variable region…
Source: BioMed CentralCategories: Genetics, Latest HeadlinesTweet
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Mashup Score: 1
Thieme E-Books & E-Journals
Source: www.thieme-connect.deCategories: Future of Medicine, Latest HeadlinesTweet
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Mashup Score: 0
Author summary As epigenetic variation is cell-type specific, an ongoing challenge in epigenetic epidemiology is how to interpret studies performed using bulk tissue (for example, whole blood) which comprises a mix of different cell types. In this study, we identified major differences in DNA methylation (DNAm) across multiple peripheral tissues and different blood cell types, with each sample…
Source: journals.plos.orgCategories: Genetics, Latest HeadlinesTweet
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Mashup Score: 3Epigenome-wide association study of COVID-19 severity with respiratory failure - PubMed - 3 year(s) ago
The Unstoppable campaign of the Josep Carreras Leukaemia Foundation, the Cellex Foundation and the CERCA Programme/Generalitat de Catalunya.
Source: PubMedCategories: Future of Medicine, Latest HeadlinesTweet
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Mashup Score: 1
We identified DNA methylation sites as epigenetic susceptibility loci for respiratory failure in COVID-19 patients. These candidate biomarkers, combined with other clinical, cellular and genetic factors, could be useful in the clinical stratification and management of patients infected with the SARS-CoV-2.
Source: EBioMedicineCategories: Future of Medicine, Latest HeadlinesTweet
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Mashup Score: 6
We identified DNA methylation sites as epigenetic susceptibility loci for respiratory failure in COVID-19 patients. These candidate biomarkers, combined with other clinical, cellular and genetic factors, could be useful in the clinical stratification and management of patients infected with the SARS-CoV-2.
Source: EBioMedicineCategories: Future of Medicine, Latest HeadlinesTweet
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Mashup Score: 1
Objective To assess the association between DNA methylation and acute myocardial infarction, the predictive added value of the identified methylation marks, and the causality of those associations. Approach and Results We conducted a case-control, two-stage, epigenome-wide association study on acute myocardial infarction (ndiscovery=391, nvalidation=204). DNA methylation was assessed using the…
Source: bioRxivCategories: Future of Medicine, Latest HeadlinesTweet
Our #EWAS collaboration with Natalia Cullell and @israelcadenas1 @IIBSantPau @HospitalSantPau @Mutua_Terrassa @UniBarcelona relates EXOC4 #methylation with #stroke outcome, article in Clinical Epigenetics @BioMedCentral https://t.co/xAxNwF9KFp https://t.co/jIKIpVkBSm