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Mashup Score: 0SnapFISH: a computational pipeline to identify chromatin loops from multiplexed DNA FISH data - 7 month(s) ago
Nature Communications – Multiplexed DNA FISH technologies are powerful tools to reveal chromatin spatial organisation. Here, the authors developed SnapFISH, a computational pipeline to identify…
Source: www.nature.comCategories: General Medicine News, Latest HeadlinesTweet
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Mashup Score: 2
Welcome! You are invited to join a webinar: TMP Distinguished Speaker Seminar Series – Dr. Manel Esteller. After registering, you will receive a confirmation email about joining the webinar.
Source: ZoomCategories: Future of Medicine, Latest HeadlinesTweet
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Mashup Score: 2
Patient-derived xenografts (PDXs) are tumour fragments engrafted into mice for preclinical studies. PDXs offer clear advantages over simpler in vitro cancer models – such as cancer cell lines (CCLs) and organoids – in terms of structural complexity, heterogeneity, and stromal interactions. We characterised 231 colorectal cancer PDXs at the genomic, transcriptomic, and epigenetic level and…
Source: bioRxivCategories: Future of Medicine, Latest HeadlinesTweet-
Glad to be part of this beautiful story, now at @biorxivpreprint, where @Francesco_i0ri0 @IorioLab @liviotrusolino and Andrea Bertotti groups show how #multiomics (of course including #epigenomics) of #colorectalcancer #pdx predicts response to #cetuximab! https://t.co/gyrM1V3w8s https://t.co/IuBMTcO1vN
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Mashup Score: 0Dynamic DNA methylation reveals novel cis-regulatory elements in mouse hematopoiesis - 1 year(s) ago
Differentiation of hematopoietic stem and progenitor cells (HSPCs) to terminally differentiated immune cells is accompanied by large-scale remodeling …
Source: www.sciencedirect.comCategories: Hem/Onc News and Journals, Latest HeadlinesTweet
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Mashup Score: 3Characterizing cis-regulatory elements using single-cell epigenomics - Nature Reviews Genetics - 2 year(s) ago
In this Review, Preissl, Gaulton and Ren discuss single-cell epigenomic methods and data analysis tools, their readiness for profiling cis-regulatory elements in human tissues and the insight they can provide into dynamic, context-specific gene regulation.
Source: NatureCategories: Healthcare Professionals, Latest HeadlinesTweet-
Characterizing cis-regulatory elements using #singlecell #epigenomics: @NatureGenet https://t.co/Vd2bgocn85 Beyond bulk cataloging human #CRE's towards goal of tissue profiling in health & disease. Check out Tables 1 - 3 for comprehensive lists of key tools and methodologies. https://t.co/67nZohZnjz
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Mashup Score: 5Fellowships Job: Postdoctoral Research Fellow-Baca Lab at Dana-Farber Cancer Institute in 450 Brookline Ave, Boston, MA - 2 year(s) ago
Postdoctoral Research Fellow-Baca Lab job
Source: careers.dana-farber.orgCategories: Hem/Oncs, Latest HeadlinesTweet-
The @SylvanBacaLab is recruiting a postdoc to work at the interface of #cancer #epigenomics and computational biology! Sylvan is one of the most talented scientists and an absolutely incredible mentor. Please RT and apply if interested! Link to the job: https://t.co/oTOdpg6lSx https://t.co/waJVDr84vX
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Mashup Score: 3
While cutaneous melanoma is linked to UV radiation, acral melanoma is not. Epigenetic mechanisms function as sensors to exposures and determinants of cell identity. Here, the authors use DNA methylation data to identify dysregulated pathways associated with UV radiation and pathobiology in cutaneous and acral melanomas.
Source: NatureCategories: Healthcare Professionals, Latest HeadlinesTweet
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Mashup Score: 11
Here, we report a lack of diversity in epigenome-wide association studies (EWAS) and DNA methylation (DNAm) data, discuss current challenges, and propose solutions for EWAS and DNAm research in diverse populations. The strategies we propose include fostering community involvement, new data generation, and cost-effective approaches such as locus-specific analysis and ancestry variable region…
Source: BioMed CentralCategories: Genetics, Latest HeadlinesTweet
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Mashup Score: 3The role of single-cell genomics in human genetics - 2 year(s) ago
Single-cell sequencing is a powerful approach that can detect genetic alterations and their phenotypic consequences in the context of human development, with cellular resolution. Humans start out as single-cell zygotes and undergo fission and differentiation to develop into multicellular organisms. Before fertilisation and during development, the cellular genome acquires hundreds of mutations…
Source: Journal of Medical GeneticsCategories: General Medicine Journals and Societies, Latest HeadlinesTweet
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Mashup Score: 0Human Gene - Journal - Elsevier - 2 year(s) ago
Human Gene is a companion title to Gene and a member of the Gene Family…
Source: www.journals.elsevier.comCategories: Genetics, Latest HeadlinesTweet
.@afhuming @yunliunc @CCLRI @4DNucleome develop SnapFISH, a computational pipeline to identify chromatin loops from multiplexed DNA FISH data. #BiotechNatureComms #Bioinformatics #Epigenomics #BiotechNatureComms https://t.co/0hJNG8DKpS