• Mashup Score: 2

    Patient-derived xenografts (PDXs) are tumour fragments engrafted into mice for preclinical studies. PDXs offer clear advantages over simpler in vitro cancer models – such as cancer cell lines (CCLs) and organoids – in terms of structural complexity, heterogeneity, and stromal interactions. We characterised 231 colorectal cancer PDXs at the genomic, transcriptomic, and epigenetic level and…

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    • Glad to be part of this beautiful story, now at @biorxivpreprint, where @Francesco_i0ri0 @IorioLab @liviotrusolino and Andrea Bertotti groups show how #multiomics (of course including #epigenomics) of #colorectalcancer #pdx predicts response to #cetuximab! https://t.co/gyrM1V3w8s https://t.co/IuBMTcO1vN

  • Mashup Score: 3

    In this Review, Preissl, Gaulton and Ren discuss single-cell epigenomic methods and data analysis tools, their readiness for profiling cis-regulatory elements in human tissues and the insight they can provide into dynamic, context-specific gene regulation.

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    • Characterizing cis-regulatory elements using #singlecell #epigenomics: @NatureGenet https://t.co/Vd2bgocn85 Beyond bulk cataloging human #CRE's towards goal of tissue profiling in health & disease. Check out Tables 1 - 3 for comprehensive lists of key tools and methodologies. https://t.co/67nZohZnjz

  • Mashup Score: 11

    Here, we report a lack of diversity in epigenome-wide association studies (EWAS) and DNA methylation (DNAm) data, discuss current challenges, and propose solutions for EWAS and DNAm research in diverse populations. The strategies we propose include fostering community involvement, new data generation, and cost-effective approaches such as locus-specific analysis and ancestry variable region…

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    • RT @charles_breeze: So glad our work on diversity in EWAS is finally out! 🎉 https://t.co/Nouye1nkEW #genomics #epigenomics #EWAS #diversi…

  • Mashup Score: 3

    Single-cell sequencing is a powerful approach that can detect genetic alterations and their phenotypic consequences in the context of human development, with cellular resolution. Humans start out as single-cell zygotes and undergo fission and differentiation to develop into multicellular organisms. Before fertilisation and during development, the cellular genome acquires hundreds of mutations…

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    • Fantastic new #OpenAccess Review: The role of single-cell genomics in human genetics https://t.co/rR9M6lc6jH #Genomics #Transcriptomics #Proteomics #Epigenomics @kas_varun @SaranyaBalach13 @malte_spielmann #Genetics #Research #RareDisease #MedicalGenetics #SingleCell https://t.co/Hbw1pzbWIj

  • Mashup Score: 0

    Human Gene is a companion title to Gene and a member of the Gene Family…

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    • Announcing a new member of the gene journal family, Human Gene. It will publish papers on #epigenomics, #geneexpression, #RNA and #genomeprojects Go to journal homepage: https://t.co/xNOX34jQre https://t.co/nDGHx2GRuB