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Mashup Score: 37
xygenation (ECMO) to determine a threshold where aPTT unresponsiveness occurs. Two hundred fourteen adults receiving bivalirudin during ECMO between 2018 and 2022 were included. Piecewise regression in a linear mixed effects model was used to determine a bivalirudin dose threshold of 0.21 mg/kg/hr for aPTT unresponsiveness. For doses of less than 0.21 mg/kg/hr (n = 135), every 0.1 mg/kg/hr dose increase led to an aPTT increase of 11.53 (95% confidence interval [CI] = 9.85–13.20) seconds compared to only a 3.81 (95% CI = 1.55–6.06) seconds increase when dose was greater than or equal to 0.21 mg/kg/hr (n = 79) (pinteraction < 0.001). In multivariable logistic regression, venovenous configuration (odds ratio [OR] = 2.83, 95% CI = 1.38–5.77) and higher fibrinogen concentration (OR = 1.22, 95% CI = 1.05–1.42) were associated with greater odds of unresponsiveness, whereas older age (OR = 0.79, 95% CI = 0.63–0.98), kidney dysfunction (OR = 0.48, 95% CI = 0.25–0.92), and a higher baseline aPTT
Source: journals.lww.comCategories: General Medicine News, Critical CareTweet
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Mashup Score: 0Advanced ECMO Cannulation for VV, VA, and ECPR | American College of Chest Physicians - 1 month(s) ago
In this course, you’ll acquire cannulation skills that can be used to place patients on venovenous and venoarterial ECMO.
Source: www.chestnet.orgCategories: General Medicine News, PulmonologyTweet
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Mashup Score: 35Source: link.springer.comCategories: General Medicine News, Critical CareTweet
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Mashup Score: 6Timing of Initiation of Extracorporeal Membrane Oxygenation Support and Outcomes Among Patients With Cardiogenic Shock - 2 month(s) ago
Background Venoarterial extracorporeal membrane oxygenation (ECMO) provides full hemodynamic support for patients with cardiogenic shock, but optimal timing of ECMO initiation remains uncertain. We…
Source: www.ahajournals.orgCategories: General Medicine News, Critical CareTweet
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Mashup Score: 12Novel Role for Cardiolipin as a Target of Therapy to Mitigate Myocardial Injury Caused by Venoarterial Extracorporeal Membrane Oxygenation - 2 month(s) ago
BACKGROUND: Cardiolipin is a mitochondrial-specific phospholipid that maintains integrity of the electron transport chain (ETC) and plays a central role in myocardial ischemia/reperfusion injury. Taf
Source: www.ahajournals.orgCategories: General Medicine News, Cardiology News and JournTweet
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Mashup Score: 25
are vital to maximizing cardiopulmonary parameters for definitive therapy. To minimize complications, many different techniques have been described including a novel off-pump direct apical cannulation for venoarterial-extracorporeal membrane oxygenation (VA-ECMO). This technique allows early ambulation and avoids peripheral artery access complications but has only been described in small case series. Our case series represents the largest summary of patients (50) using this technique and contains the only comparison data to date. Fifty-four percentage of our patients were Society for Cardiovascular Angiography and Interventions (SCAI) stage D and 22% were arrested before cannulation. We achieved flows on average >5 L/min and most patients required biventricular drainage (86%) and an oxygenator (92%). Thirty day survival was 56% and most survivors were bridged to heart transplant (30%). Our most common complication was bleeding (16%). This technique showed significant improvement in eje
Source: journals.lww.comCategories: General Medicine News, Critical CareTweet
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Mashup Score: 0Advanced ECMO Cannulation for VV, VA, and ECPR | American College of Chest Physicians - 2 month(s) ago
In this course, you’ll acquire cannulation skills that can be used to place patients on venovenous and venoarterial ECMO.
Source: www.chestnet.orgCategories: General Medicine News, PulmonologyTweet
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Mashup Score: 8
The use of extracorporeal membrane oxygenation (ECMO) to support patients with cardiac arrest, cardiogenic shock, and acute respiratory distress syndrome is rising worldwide. 1 While ECMO may save the lives of some of our sickest patients, the outlook of ECMO survivorship remains uncertain. Defining longer-term functional and neuropsychiatric outcomes in ECMO survivors is important for 3 reasons. First, critically ill patients are at high risk of experiencing postintensive care syndrome (PICS), defined
Source: www.neurology.orgCategories: General Medicine News, NeurologyTweet
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Mashup Score: 11Calcium Channel Blocker Overdose: What Role Does... : ASAIO Journal - 3 month(s) ago
perglycemia. Expert consensus recommends treatment with calcium, high-dose insulin, inotropes, and vasopressors. Our systematic review evaluated when to initiate ECMO in the CCBOD population and the mortality rate associated with use. Electronic literature review identified all relevant studies for CCBOD and ECMO. PRISMA guidelines for systematic review were followed. Three independent authors reviewed abstracts and full texts, and only CCB ingestion without polypharmacy was included. Two authors independently collected data, which included demographics, current medical treatments, ECMO type, and survival. From 314 abstracts, 25 papers were included with a median publication year of 2019. Twenty-six patients were included with an average age of 32.7 years and 42%/58% male/female. Average time on ECMO 4.3 days. VA and VV ECMO use were 92.3% and 7.7%, respectively, and 84.6% of patients survived to hospital discharge. Before ECMO, most patients received 4-5 medical treatments (53.8%). Ou
Source: journals.lww.comCategories: General Medicine News, Critical CareTweet-
Calcium channel blocker overdose can lead to significant cardiopulmonary dysfunction, resulting in cardiac depression & vasoplegia. Here systematic review aimed to assess the role & outcome of #ECMO support, reporting high survival rate. @asaiojournal 🖇️ https://t.co/5w4U0Nt6G7 https://t.co/lpQKpegEQl
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Mashup Score: 1COVID-19 Registry Dashboard | ECMO | ECLS - 3 month(s) ago
View details of ECMO-supported COVID-19 cases in the ELSO Registry, including COVID-19 ECMO counts by ELSO chapter. Filter patient data by region and patient age, plus view outcomes, pre-ECMO patient factors, pre-ECMO interventions, patient status and complication
Source: www.elso.orgCategories: General Medicine News, Hem/OncsTweet
Bivalirudin & aPTT in adults in #ECMO 🔍 > 200 pts, 2018-22 🩸 ⬇️ aPTT response if doses > 0.21 mg/kg/hr in ECLS ⚠️ risk factors associated with aPTT unresponsiveness: VV, ⬆️ fibrinogen, younger age, no kidney dysfunction, ⬇️ baseline aPTT @asaiojournal 🔓 https://t.co/q94YLLvvr6 https://t.co/56Tuzs9WC2