• Mashup Score: 3

    The life history theory assumes that all organisms are under selective pressure to harvest external resources and allocate them to maximise fitness: only organisms making the best use of energy obtain the greatest fitness benefits. The trade-off of energy spans four functions: maintenance, growth, reproduction, and defence against pathogens. The innovative antihyperglycaemic agents glucagon-like peptide 1 (GLP-1) receptor agonists and sodium-glucose cotransporter 2 (SGLT2) inhibitors decrease bodyweight and have the potential to counter low-grade inflammation.

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    • Personal View: #Glucose-lowering #drugs with #cardiovascular benefits as modifiers of critical elements of the human life history https://t.co/FdnQia5S6d #diabetes #obesity #SGLT2 inhibitors #GLP-1 receptor agonists

  • Mashup Score: 20

    Researchers developed an AI system called ProteinSGM, which uses generative diffusion to create entirely new therapeutic proteins. The model learns from image representations to generate fully new proteins that appear to be biophysically real, meaning they fold into configurations that enable them to carry out specific functions within cells.

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    • RT @enilev: Novel #Proteins Designed With #GenerativeAI @UofT 👉https://t.co/u3d8BF1byR #neuroscience #drugs #HealthTech #Digitalhealth…

  • Mashup Score: 0

    This cross-sectional study evaluates regulatory decisions and health technology assessments in Australia, Canada, and the UK regarding new drugs approved by the US Food and Drug Administration in 2017 through 2020, as well as estimates the US cost per patient per year for drugs receiving negative…

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    • 23% of #FDA-approved #drugs 2017-20 not recommended for use/reimbursement in other countries: 💊unfavourable/uncertain benefits 💊unacceptably high $ Median (IQR) cost of these drugs USD 115 281 (166 690) per pt / year! Gotta wonder re data on devices! https://t.co/MXvlxXqxoB