• Mashup Score: 1

    An accurate diagnosis of IgE-mediated allergies is necessary to inform risk management for severe allergic reactions including anaphylaxis for food, venom, and drug allergies. The most widely available laboratory test for allergy is serum-specific IgE testing, which is routinely used for food allergy and insect sting allergy. Testing for specific IgE is limited by high sensitivity and low specificity, resulting in concern regarding overdiagnosis. Testing of allergen components has led to improved diagnosis for some food and venom allergens.

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  • Mashup Score: 2

    Drug reaction with eosinophilia and systemic symptoms (DRESS) is a type IV hypersensitivity reaction manifesting with internal organ involvement, lymphadenopathy, hematologic abnormalities, and cutaneous lesions.1 Common culprits include allopurinol, antiepileptics, and antibiotics. Systemic corticosteroids are the mainstay of active intervention for this severe cutaneous adverse reaction (SCAR); however, this is associated with negative side effects, particularly with prolonged use, as is often required for DRESS.

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    The CDC has awarded $279 million to 49 states, the District of Columbia and 40 local health departments to address rising drug overdoses in communities, the agency announced.“The growing overdose crisis particularly among young people requires urgent action,” CDC Director Mandy K. Cohen, MD, MPH, said in a press release. “To help, CDC is providing funding that will allow

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