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Mashup Score: 4Senators ask defense department for update on steps to cut risks to military drug supply chain - 7 day(s) ago
The group requested details on implementation progress by April 1.
Source: www.cidrap.umn.eduCategories: General Medicine News, Infectious DiseaseTweet
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Mashup Score: 17Drug-resistant tuberculosis responds rapidly to bedaquiline-based second-line therapy - 30 day(s) ago
Patients who have drug-resistant tuberculosis (TB) have a similar microbiological response to bedaquiline-based second-line medications as patients with drug-sensitive TB taking first-line regimens, according …
Source: medicalxpress.comCategories: General Medicine News, General HCPsTweet
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Mashup Score: 6US FDA breakthrough therapy designation and consumer drug advertising: a recipe for confusion - 1 month(s) ago
Neeraj G Patel and colleagues examine how drugs approved through the FDA breakthrough pathway are advertised to consumers and argue that the name contributes to overestimation of benefits In 2012, the US Congress gave the Food and Drug Administration authority to grant “breakthrough therapy” designation to expedite development and regulatory review of new drugs. The designation is used for potential treatments for serious conditions when preliminary evidence suggests they may perform substantially better than available alternatives on “clinically significant endpoints.” Preliminary evidence can include surrogate marker endpoints reasonably likely to predict clinical benefit, such as imaging changes and biomarkers. The programme has been successful in at least one way: an analysis of FDA approved drugs from 2015 to 2022 found that breakthrough designation was associated with a two year reduction in clinical development time.1 However, these therapies are approved on the basis of less ri
Source: www.bmj.comCategories: General Medicine News, General HCPsTweet
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Mashup Score: 26
Astrocytomas are the most common type of brain tumors in children. Activated BRAF protein kinase mutations are characteristic of pediatric astrocyt…
Source: www.pnas.orgCategories: General Medicine News, General HCPsTweet
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Mashup Score: 0Reducing drug use improves clinical outcomes in patients with stimulant use disorder - 2 month(s) ago
Reduced drug use was linked to lower levels of craving, depression and other drug-related problems among individuals with stimulant use disorder, even if they did not achieve abstinence, according to a study published in Addiction.“These findings align with an evolving understanding in the field of addiction, affirming that abstinence should be neither the sole aim nor only valid outcome of
Source: www.healio.comCategories: General Medicine News, General HCPsTweet
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Mashup Score: 11
Nature Chemical Biology – A chemical screen identified a small molecule inhibitor of CHEK2 that boosts insulin secretion in human β cells, including those from both healthy and type 2 diabetic…
Source: www.nature.comCategories: General Medicine News, General HCPsTweet
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Mashup Score: 1The Value of Current Laboratory Tests in Diagnosing Food, Venom, and Drug Allergies - 6 month(s) ago
An accurate diagnosis of IgE-mediated allergies is necessary to inform risk management for severe allergic reactions including anaphylaxis for food, venom, and drug allergies. The most widely available laboratory test for allergy is serum-specific IgE testing, which is routinely used for food allergy and insect sting allergy. Testing for specific IgE is limited by high sensitivity and low specificity, resulting in concern regarding overdiagnosis. Testing of allergen components has led to improved diagnosis for some food and venom allergens.
Source: www.jaci-inpractice.orgCategories: Allergy-Immunology, Latest HeadlinesTweet
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Mashup Score: 0Omalizumab Drug Survival in Chronic Urticaria: A Retrospective Multicentric French Study - 6 month(s) ago
Omalizumab (OMA) dramatically improves disease control and quality of life in patients with chronic urticaria (CU).
Source: www.jaci-inpractice.orgCategories: Allergy-Immunology, Latest HeadlinesTweet
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Mashup Score: 2Dupilumab to treat drug reaction with eosinophilia and systemic symptoms: A case series - 6 month(s) ago
Drug reaction with eosinophilia and systemic symptoms (DRESS) is a type IV hypersensitivity reaction manifesting with internal organ involvement, lymphadenopathy, hematologic abnormalities, and cutaneous lesions.1 Common culprits include allopurinol, antiepileptics, and antibiotics. Systemic corticosteroids are the mainstay of active intervention for this severe cutaneous adverse reaction (SCAR); however, this is associated with negative side effects, particularly with prolonged use, as is often required for DRESS.
Source: www.jaci-inpractice.orgCategories: Allergy-Immunology, Latest HeadlinesTweet
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Mashup Score: 0CDC gives $279M toward reducing drug overdoses in US - 7 month(s) ago
The CDC has awarded $279 million to 49 states, the District of Columbia and 40 local health departments to address rising drug overdoses in communities, the agency announced.“The growing overdose crisis particularly among young people requires urgent action,” CDC Director Mandy K. Cohen, MD, MPH, said in a press release. “To help, CDC is providing funding that will allow
Source: www.healio.comCategories: General Medicine News, Latest HeadlinesTweet
Senators ask defense department for update on steps to cut risks to military #drug supply chain The group requested details on implementation progress by April 1. https://t.co/a90E37nTeI https://t.co/vn0xLczWwj