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Mashup Score: 1Deficiency of the Intramembrane Protease SPPL2a Alters Antimycobacterial Cytokine Responses of Dendritic Cells - 1 year(s) ago
Key Points. SPPL2a−/− mice exhibit loss of cDC2 in lymphatic tissues.SPPL2a deficiency shifts cytokine profiles of DCs activated by mycobacteria.Accumulating CD
Categories: Allergy-Immunology, Latest HeadlinesTweet
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Mashup Score: 5
Abstract. Oncolytic viral therapies induce direct killing of tumor cells and activation of conventional dendritic cells (cDCs); however, cDC activation has not been optimized with current therapies. We evaluated adenoviral delivery of engineered membrane-stable CD40L (MEM40) and IFNβ to locally activate cDCs in mouse tumor models. Combined tumor MEM40 and IFNβ expression induced the highest cDC…
Categories: General Medicine News, Latest HeadlinesTweet-
Researchers discover new pathways to activate #dendriticcells, produce strong anti-tumor immunity https://t.co/LZpgpOFARJ https://t.co/EdHhHwgpLd
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Mashup Score: 0Study Reveals Mechanism Involved in Neuropathic Pain and Could Help Develop Specific Treatment - Neuroscience News - 1 year(s) ago
Study reveals the role played by neuropathic pain in dendritic cells in the meninges via an increase in the metabolic kynurenine pathway. When the kynurenine pathway initiated by IDO1 was blocked, neuropathic pain was nullified.
Source: Neuroscience NewsCategories: Healthcare Professionals, Latest HeadlinesTweet-
Study Reveals Mechanism Involved in #NeuropathicPain: https://t.co/S3GyEJwLrp via @neurosciencenew Meningeal #dendriticcells drive neuropathic pain by elevation of the #kynurenine metabolic pathway in mice. @jclinicalinvest https://t.co/xN3hzIRQsR #ChronicPain #Neuroinflammation https://t.co/PTbeWTHXVW
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Mashup Score: 4CD40 Drives Central Nervous System Autoimmune Disease by Inducing Complementary Effector Programs via B Cells and Dendritic Cells - 1 year(s) ago
Key Points. CD40 supports distinct effector programs in B cells and DCs for EAE.CD40 expression on DCs is required for priming pathogenic Th cells.B cell CD40 i
Categories: Allergy-Immunology, Latest HeadlinesTweet-
#AAI_Fellow Richard J. Hodes @NINDSnews @NIHAging | The costimulatory molecule #CD40 drives #CNS #autoimmunity through #Bcells and #DendriticCells by distinct pathways | #ReadTheJI #immunology #EAE #MS 👉 https://t.co/Aq6DzGQQS4 https://t.co/u2L6c2MnrR
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Mashup Score: 4Vitamin E Enhances Cancer Immunotherapy by Reinvigorating Dendritic Cells via Targeting Checkpoint SHP1 - 2 year(s) ago
Among common dietary supplements, vitamin E intake increases cancer immunotherapy responses by directly inhibiting the SHP1 checkpoint in dendritic cells, which improves antigen presentation and activates T-cell antitumor immunity.
Categories: Hem/Onc News and Journals, Latest HeadlinesTweet-
From the July issue: #VitaminE Enhances Cancer #Immunotherapy by Reinvigorating #DendriticCells via Targeting Checkpoint SHP1, by @DihuaYu et al. https://t.co/QZ7DjPuWOQ @MDAndersonNews https://t.co/xfCnPvu4ve
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Mashup Score: 2Epigenetic Activation of Plasmacytoid DCs Drives IFNAR-Dependent Therapeutic Differentiation of AML - 2 year(s) ago
Type I IFN produced by plasmacytoid dendritic cells in response to histone deacetylase inhibition is required to induce differentiation of leukemia cells and ultimately tumor cell death in acute myeloid leukemia.
Categories: Hem/Onc News and Journals, Latest HeadlinesTweet-
Epigenetic activation of plasmacytoid #dendriticcells drives IFNAR-dependent therapeutic #differentiation of acute myeloid #leukemia, by @salmon_jess, @JohnstoneRicky et al. https://t.co/a4prcXAQe6 @JohnstoneLab @todorovizabela @Pilar_dominguez @PeterMacCC @PeterMacRes #leusm https://t.co/o08Fe6AiEj
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Mashup Score: 0TLR3-Activated Monocyte-Derived Dendritic Cells Trigger Progression from Acute Viral Infection to Chronic Disease in the Lung - 2 year(s) ago
This article is featured in Top Reads , p.[1115][1] [1]: /lookup/volpage/206/1115
Source: The Journal of ImmunologyCategories: Allergy-Immunology, Latest HeadlinesTweet-
#ICYMI from @MJHoltzmanlab @WUSTLmed | #TLR3-Activated #Monocyte-Derived #DendriticCells Trigger Progression from Acute Viral Infection to Chronic Disease in the Lung #Inflammation #ReadtheJI #MoDCs https://t.co/052exMOP2y https://t.co/50QL8Ik7vV
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Mashup Score: 9
Combining a retrospective analysis of clinical records with in-depth laboratory studies, researchers at The University of Texas MD Anderson Cancer Center have discovered that vitamin E can enhance immunotherapy responses by stimulating the activity of dendritic cells in the tumor. The findings were published today in Cancer Discovery.
Source: medicalxpress.comCategories: General Medicine News, Latest HeadlinesTweet-
#VitaminE can boost immunotherapy responses by reinvigorating #dendriticcells https://t.co/rkV10UkQDT
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Mashup Score: 7Epigenetic activation of plasmacytoid DC drives IFNAR-dependent therapeutic differentiation of AML - 2 year(s) ago
Abstract. Pharmacological inhibition of epigenetic enzymes can have therapeutic benefit against hematological malignancies. In addition to affecting tumor cell growth and proliferation, these epigenetic agents may induce anti-tumor immunity. Here we discovered a novel immuno-regulatory mechanism through inhibition of histone deacetylases (HDACs). In models of AML, leukemia cell differentiation…
Categories: Hem/Onc News and Journals, Latest HeadlinesTweet-
Epigenetic activation of plasmacytoid #dendriticcells drives IFNAR-dependent therapeutic #differentiation of acute myeloid #leukemia by @salmon_jess et al. https://t.co/0smmpxSKzD @todorovizabela @Pilar_dominguez @JohnstoneRicky @JohnstoneLab @PeterMacCC @PeterMacRes #leusm https://t.co/awr0q03f0Z
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Mashup Score: 6Single-cell transcriptional profiling informs efficient reprogramming of human somatic cells to cross-presenting dendritic cells - 2 year(s) ago
PU.1, IRF8, and BATF3 cooperation and inflammatory signaling orchestrate efficient programming of human cDC1-like cells.
Source: Science ImmunologyCategories: Allergy-Immunology, Latest HeadlinesTweet-
New study uses single cell transcriptomics to optimize reprogramming of human #fibroblasts into cross-presenting #DendriticCells with high efficiency. https://t.co/qo98aZbhyk https://t.co/pVZI9QMyrA
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#ICYMI from Bernd Schröder @tudresden_de | The intramembrane #protease SPPL2a shifts the balance from #antiinflammatory to #proinflammatory #cytokine production in #DendriticCells | #ReadTheJI #immunology 👉 https://t.co/2KijwJsCkq https://t.co/GMi9vdEa7T