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Mashup Score: 6
Membrane-bound E3 ubiquitin ligases RNF43 and ZNRF3 are overexpressed in colorectal cancer, and can be repurposed using proteolysis-targeting antibodies (PROTABs) to selectively degrade cell-surface receptors in tumours.
Source: NatureCategories: Hem/Oncs, Latest HeadlinesTweet-
New exciting kind of protein degraders "proteolysis-bispecific antibodies". The receptor can be degraded by using E3 ubiquitin ligases with exposed extracellular domain: work by @genentech scientists in @Nature. Fascinating! #PROTABs https://t.co/jNW1zWht9d https://t.co/BkUrn3fiEs
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Mashup Score: 9Mapping the Degradable Kinome Provides a Resource for Expedited Degrader Development - 3 year(s) ago
A synthetic chemistry and chemo-proteomics platform used to annotate the “degradable kinome” provides chemical leads for developing degraders of approximately 200 distinct kinase targets and offers new general design principles for developing future kinase degraders.
Source: CellCategories: General Medicine Journals and Societies, Latest HeadlinesTweet-
New Resource Out Now! This synthetic #chemistry and chemo-#proteomics platform provides chemical leads for developing #degraders of ~200 distinct #kinase targets and offers new design principles for developing kinase degraders https://t.co/TWCYad8DnG @fischerlab1 @DanaFarber https://t.co/FEEQ3NhvbE
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Mashup Score: 8Mapping the Degradable Kinome Provides a Resource for Expedited Degrader Development - 3 year(s) ago
A synthetic chemistry and chemo-proteomics platform used to annotate the “degradable kinome” provides chemical leads for developing degraders of approximately 200 distinct kinase targets and offers new general design principles for developing future kinase degraders.
Source: CellCategories: General Medicine Journals and Societies, Latest HeadlinesTweet-
New Resource online now! A synthetic #chemistry and chemo-#proteomics platform provides chemical leads for developing #degraders of approximately 200 distinct #kinase targets and offers new #design principles for developing kinase degraders. https://t.co/9eaBLJPv9d https://t.co/HrFsdoZXnn
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New exciting kid in the block of degraders: proteolysis-targeting antibodies. These bispecific molecules allow ‘on-demand’ receptor degradation by using E3 ubiquitin ligases with exposed extracellular domains. #cancer #degraders https://t.co/8aEo8RmSz1 https://t.co/iGgEUm8Ieb