-
Mashup Score: 0Online Event - 6 month(s) ago
Blood fats are key biomarkers for heart, liver, and other diseases, highlighting the importance of lipid metabolism for health. Lipoprotein lipase (LPL) is a key enzyme involved in hydrolyzing triglycerides from circulating lipoproteins in the blood, releasing free fatty acids. Understanding the structural and functional aspects of LPL is crucial, given its significant role in lipid metabolism and related diseases. In this webinar, the speaker will describe experiments that uncovered how LPL interacts
Source: view6.workcast.netCategories: Future of Medicine, Latest HeadlinesTweet
-
Mashup Score: 4Scaling up cryo-EM for biology and chemistry: The journey from niche technology to mainstream method - 7 month(s) ago
In this review, de la Cruz and Eng discuss major developments in single-particle analysis, electron tomography, and microcrystal electron diffraction to show how cryo-EM has matured to become an ever-improving technology for visualizing molecular structure.
Source: www.cell.comCategories: Hem/Onc News and Journals, Latest HeadlinesTweet-
Just out in @Structure_CP, MSK’s Jason de la Cruz and Edward Eng, of the New York Structural Biology Center, review recent advances in modern #cryoEM and assess how they are contributing to the future of the field. #cryoET #MicroED https://t.co/JRGfeUH3eb
-
-
Mashup Score: 2EMPIAR-11338 Cryo-EM SPA dataset for Antibody SKV09 in complex with VEEV VLP (K3 movies/.tif files) - 9 month(s) ago
EMPIAR, the Electron Microscopy Public Image Archive centered at EMBL-EBI, is a public resource for raw electron microscopy images related to EMDB, contains micrographs, particle sets and tilt-series.
Source: www.ebi.ac.ukCategories: General Medicine Journals and Societies, Latest HeadlinesTweet-
RT @EMDB_EMPIAR: https://t.co/UtgNymCogA is a #CryoEM dataset for Antibody SKV09 in complex with VEEV VLP and sheds light on the structural…
-
-
Mashup Score: 2Bipartite genome and structural organization of the parvovirus Acheta domesticus segmented densovirus - Nature Communications - 9 month(s) ago
Parvoviruses have been reported to carry a linear monopartite ssDNA genome. In this study, the authors isolated an insect-infecting parvovirus with a bipartite genome from house crickets and discovered a genome packaging strategy distinct from other parvoviruses.
Source: NatureCategories: General Medicine News, Latest HeadlinesTweet-
Bipartite genome and structural organization of a parvovirus that infects crickets (Parvoviruses have so far been reported to carry a linear monopartite ssDNA genome) @judit_penzes #cryoEM #virology #ssDNAviruses https://t.co/OiYIjTFw2w https://t.co/u72y5XsnP7
-
-
Mashup Score: 4Bipartite genome and structural organization of the parvovirus Acheta domesticus segmented densovirus - Nature Communications - 10 month(s) ago
Parvoviruses have been reported to carry a linear monopartite ssDNA genome. In this study, the authors isolated an insect-infecting parvovirus with a bipartite genome from house crickets and discovered a genome packaging strategy distinct from other parvoviruses.
Source: NatureCategories: General Medicine News, Latest HeadlinesTweet-
Bipartite genome and structural organization of a parvovirus that infects crickets (Parvoviruses have so far been reported to carry a linear monopartite ssDNA genome) @judit_penzes #cryoEM #virology #ssDNAviruses https://t.co/OiYIjTFw2w https://t.co/Vxvc8Kvjbn
-
-
Mashup Score: 7Cryo-electron microscopy of the f1 filamentous phage reveals insights into viral infection and assembly - Nature Communications - 11 month(s) ago
In this work, the authors report a system for production of short versions of a filamentous phage enables the structure to be determined by cryo-electron microscopy. Structure combined with mutagenesis allows the identification of phage domains that are important in bacterial attack and for release of new viral progeny.
Source: NatureCategories: General Medicine News, Latest HeadlinesTweet-
Scientists from @the_gold_lab report the #CryoEM structure of f1 filamentous #phage & provide insights into the domains important in bacterial attack & release of new viral progeny. @conners_becky @rayenleonq @MicroMassey @LSIExeter @NatSciMassey https://t.co/bKMytlpxLH https://t.co/eJDou82ZMj
-
-
Mashup Score: 2Cryo-EM structure of human eIF5A-DHS complex reveals the molecular basis of hypusination-associated neurodegenerative disorders - Nature Communications - 12 month(s) ago
eIF5A is the only protein known to contain hypusine. Here, the authors present the cryoEM structure of the eIF5A-DHS complex and provide mechanistic insights to understand the deoxyhypusination reaction and hypusination-related neurodegeneration.
Source: NatureCategories: General Medicine News, Latest HeadlinesTweet-
Researchers @JagiellonskiUni present the cryoEM structure of the eIF5A-DHS complex and provide mechanistic insights on the deoxyhypusination reaction and hypusination-related neurodegeneration. #hypusination #cryoEM #crystallography https://t.co/ucyUMpb4GY https://t.co/VPNw9R7WN5
-
-
Mashup Score: 11Disease-relevant β2-microglobulin variants share a common amyloid fold - Nature Communications - 1 year(s) ago
The authors use cryo-EM to determine amyloid fibrils structures of disease relevant variants of β2-microglobulin in vitro. Each variant is polymorphic, but all polymorphs from all samples are built from a a lego-like assembly of common building blocks, suggesting a one amyloid fold’ paradigm.
Source: NatureCategories: General Medicine News, Latest HeadlinesTweet-
Scientists from @AstburyCentre and @radfordlab observe an #AmyloidLego like assembly in amyloid fibrils of disease relevant variants of β2-microglobulin in vitro, suggesting a one amyloid fold paradigm. @ScienceLeeds @naranson @milkowilko #CryoEM https://t.co/xHlFcEDfyS https://t.co/aiQKXZUaEL
-
-
Mashup Score: 5rRNA methylation by Spb1 regulates the GTPase activity of Nog2 during 60S ribosomal subunit assembly - Nature Communications - 1 year(s) ago
Regulation of 60S biogenesis remains poorly understood. Using cryo-EM, the authors show that failure of Spb1 to methylate the A-loop nucleotide G2922 prematurely activates the GTPase Nog2, suggesting that Spb1 and Nog2 form a kinetic checkpoint during ribosome maturation.
Source: NatureCategories: General Medicine News, Latest HeadlinesTweet-
Researchers from @erzbergerlab, @biophysics_utsw, @MolBiophysUTSW, including @victor_ecr and @sekulskikamil, report insights into the roles of rRNA methylation and GTPase Nog2 in 60S biogenesis. #ribosome, #RNA, #CryoEM https://t.co/9RYt6cIoyS https://t.co/rKxWbfIL1K
-
-
Mashup Score: 0Structural basis for clearing of ribosome collisions by the RQT complex - Nature Communications - 1 year(s) ago
Ribosome collisions serve as proxy for aberrant translation to initiate rescue and quality control pathways. Here, authors elucidate the molecular mechanism of collided ribosome clearance by the ribosome quality control trigger complex.
Source: NatureCategories: General Medicine News, Latest HeadlinesTweet-
Researchers from@BeckmannLab, @GeneCenter_LMU, @inada_lab elucidate the molecular mechanism of collided ribosome clearance by the ribosome quality control trigger complex. #ribosomes, #CryoEM https://t.co/qfV2BPJ5IX https://t.co/U0bBkiEJAF
-
Join #ScienceWebinars for their next #Technology broadcast on Wednesday, 18 October at 12 p.m ET ➡️ A fresh look at fat metabolism: Studying lipoprotein lipase oligomerization dynamics with #cryoEM and mass photometry. Register today: https://t.co/URiw43ct6F https://t.co/Ohxjtjs5Sp