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    Author links open overlay panel Ankita Agarwal MD, MSc a, Joseph Marion PhD b, Paul Nagy PhD c d, Matthew Robinson MD e, Allan Walkey MD, MSc f, Jonathan Sevransky MD, MHS a • Current challenges to interventional trials and critical care research include an inefficient trial design, heterogenous patient populations, heterogeneous treatment effects, and difficulties with patient enrollment. • Precise phenotyping of critically ill patients may allow more targeted enrollment of patients in critical care

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