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Mashup Score: 0Complement: The Road Less Traveled - 1 year(s) ago
Abstract. The complement field has recently experienced a strong resurgence of interest because of the unexpected discovery of new complement functions extendin
Categories: Allergy-Immunology, Latest HeadlinesTweet
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Mashup Score: 2The Role of Complement in Autoimmune Disease-Associated Thrombotic Microangiopathy and the Potential for Therapeutics - 1 year(s) ago
The complement system is a tightly regulated, cascading protein network representing a key component linking the innate and humoral immune systems. However, if misdirected or dysregulated, it can be similarly damaging to host-tissue. The role of complement dysregulation on vascular endothelial cells has been well established in atypical hemolytic uremic syndrome (aHUS), a thrombotic…
Source: The Journal of RheumatologyCategories: Latest Headlines, RheumatologyTweet-
IMO, thrombotic microangiopathies (TMAs) are underdiagnosed in autoimmune diseases such as SLE. Led by @anuja_java, we discuss the role & extent of #complement involvement in secondary autoimmune TMAs, and how this can guide Tx with targeted therapies. https://t.co/vtfrt4rr2C
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Mashup Score: 0Molecular signatures of intrarenal complement receptors C3AR1 and C5AR1 correlate with renal outcome in human lupus nephritis - 1 year(s) ago
Objective Lupus nephritis is one of the most common and serious complications of systemic lupus erythematosus (SLE). Lupus nephritis is a major cause of kidney failure in patients with SLE, attributed to increased morbidity and mortality. The in situ deposition of intrarenal immune complexes promotes the accumulation of inflammatory cells and causes kidney injury. Methods We here extracted…
Source: Lupus Science & MedicineCategories: Latest Headlines, RheumatologyTweet-
This week on LSM: Here show that #intrarenal expression of #complement #receptor C3AR1 and C5AR1 is correlated with treatment success specifically in class III #lupusnephritis. #Lupus #SLE #Autoimmunity #Rheumatology https://t.co/UHAcgpRsZW
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Mashup Score: 1
Key Points. The complement system plays a pathophysiologic role in the synovium of early RA.Correlations were found between DAS28 and complement genes in the ea
Categories: Allergy-Immunology, Latest HeadlinesTweet-
#ICYMI from V. Michael Holers @CUMedicalSchool | Analysis of #complement expression and biodistribution in the synovium of early #RheumatoidArthritis patients | #ReadTheJI #immunology #RheumTwitter #RA 👉 https://t.co/wL2mv0ctfc https://t.co/P1e3JEDxWU
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Mashup Score: 0Molecular signatures of intrarenal complement receptors C3AR1 and C5AR1 correlate with renal outcome in human lupus nephritis - 1 year(s) ago
Objective Lupus nephritis is one of the most common and serious complications of systemic lupus erythematosus (SLE). Lupus nephritis is a major cause of kidney failure in patients with SLE, attributed to increased morbidity and mortality. The in situ deposition of intrarenal immune complexes promotes the accumulation of inflammatory cells and causes kidney injury. Methods We here extracted…
Source: Lupus Science & MedicineCategories: Latest Headlines, RheumatologyTweet-
This week on LSM: Here show that #intrarenal expression of #complement #receptor C3AR1 and C5AR1 is correlated with treatment success specifically in class III #lupusnephritis. #Lupus #SLE #Autoimmunity #Rheumatology https://t.co/UHAcgpRsZW
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Mashup Score: 0Insights into the Antibacterial Properties of Complement Peptides C3a, C4a, and C5a across Vertebrates - 1 year(s) ago
Key Points. The antibacterial properties of vertebrate C3a, C4a, and C5a have evolved divergently.Net charge is the determining factor of the antibacterial prop
Categories: Allergy-Immunology, Latest HeadlinesTweet-
Insights into the #Antibacterial properties of #complement peptides C3a, C4a, and C5a across vertebrates | from Yong-An Zhang at Huazhong Agricultural University | #ReadTheJI #VisualAbstract #structuralimmunology #comparativeimmunology 👉 https://t.co/t6dTxDuWY1 https://t.co/F9cgthOYt4
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Mashup Score: 0Molecular signatures of intrarenal complement receptors C3AR1 and C5AR1 correlate with renal outcome in human lupus nephritis - 1 year(s) ago
Objective Lupus nephritis is one of the most common and serious complications of systemic lupus erythematosus (SLE). Lupus nephritis is a major cause of kidney failure in patients with SLE, attributed to increased morbidity and mortality. The in situ deposition of intrarenal immune complexes promotes the accumulation of inflammatory cells and causes kidney injury. Methods We here extracted…
Source: Lupus Science & MedicineCategories: Latest Headlines, RheumatologyTweet-
This week on LSM: Here show that #intrarenal expression of #complement #receptor C3AR1 and C5AR1 is correlated with treatment success specifically in class III #lupusnephritis. #Lupus #SLE #Autoimmunity #Rheumatology https://t.co/UHAcgpRsZW
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Mashup Score: 4Paper: Cold Exposure Induces Vaso-Occlusion and Hyperalgesia in Mice with Sickle Cell Disease That Is Dependent on Complement Activation - 1 year(s) ago
Oral and Poster Abstracts Oral 113. Hemoglobinopathies, Excluding Thalassemia: Basic and Translational: Cognitive Deficit, Pain, and Inflammation in Sickle Cell Disease: What We Learned from Mouse Models Research, Fundamental Science, Sickle Cell Disease, Translational Research, Hemoglobinopathies, Diseases, Biological Processes, Study Population, pathogenesis, Animal…
Source: ash.confex.comCategories: Hem/Oncs, Latest HeadlinesTweet-
Cold weather can trigger a pain crisis for people living with #SickleCellDisease. By studying mechanisms that lead to this response, including the role of #complement, an ancient part of the immune system, researchers aim to inform future treatment: https://t.co/OCcn9URtS8 #ASH22 https://t.co/Zwnm8QUm9N
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Mashup Score: 1Breakthrough Hemolysis in PNH with Proximal or Terminal Complement Inhibition | NEJM - 2 year(s) ago
Review Article from The New England Journal of Medicine — Breakthrough Hemolysis in PNH with Proximal or Terminal Complement Inhibition
Source: New England Journal of MedicineCategories: Hem/Oncs, Latest HeadlinesTweet-
#Breakthrough #Hemolysis in #PNH with Proximal or Terminal #Complement Inhibition👇 https://t.co/0ksGVDWLAc @lucioluzzatto #C5Inhibition https://t.co/I6dYxyU5T9
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Mashup Score: 0
This article is featured in Top Reads , p.[][1] [1]: /lookup/volpage/208/2079
Source: The Journal of ImmunologyCategories: Allergy-Immunology, Latest HeadlinesTweet-
#JI_TopRead #AuthorChoice from Piet Gros @UniUtrecht | Multi-faceted activities of seven #nanobodies against #complement C4b #ReadTheJI #immunology #Antibodies #MolecularBiology https://t.co/SvCrJRzDPs https://t.co/Zvvl16iJXE
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Noncanonical roles of #complement: #BriefReview by @CKemperLab Viviana Ferreira, @JeanneTPaz V. Michael Holers, @LionakisLab & Jessy Alexander | #ReadTheJI #fungalimmunity #neuroimmunity @NIH @UBuffalo @UToledoMed @GladstoneInst @CUAnschutz 👉 https://t.co/ic2YweXaRf https://t.co/PJ50ZxY2i4