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    In a Healio video exclusive, Rene D. Gomez-Esquivel, MD, discusses risk factors for pediatric colon cancer, as well as best practices for screening and lesion resection, from his presentation at the 2023 NASPGHAN annual meeting. “Colon cancer is the most common solid tumor of the GI tract in pediatrics,” Gomez-Esquivel, associate professor of medicine and pediatrics at Morsani

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    • In a @GoHealio #GI 🎥 exclusive, Rene D. Gomez-Esquivel, MD, of @USFHealthMed, discussed risk factors for pediatric 👧🏻👦🏾 #coloncancer, as well as best practices for screening and lesion resection Learn more from #NASPGHAN23 below 👇🏻 https://t.co/eZv5gC9F39

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    There have been demonstrated differences in tumor cell metabolism between right-sided and left-sided colorectal tumors, which could explain the differences observed in their clinical behavior, especially in metastatic disease. Now, new research has found that patients with right-sided colorectal tumors that spread to the liver had worse survival rates than those with left-sided tumors that had also metastasized to the liver. The findings, published by Morris et al in Cancer Letters, provide i nsight into

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    • Does Colon Tumor Location Matter? https://t.co/leQTLZ9Ic4 #crcsm #coloncancer

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    Increases in colorectal cancer screening are linked to the declining incidence of the disease over the past 3 decades. These favorable trends, however, are not observed in marginalized racial and ethnic populations with disproportionately lower rates of screening, higher disease incidence, and increased mortality, despite advances in health technology and policy. This review describes the differences in screening uptake and test selection among racial and ethnic groups, discusses known obstacles and facilitators that impact screening, and highlights existing frameworks developed to achieve health equity in colorectal cancer screening.

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    • #ColonCancer is the 3rd most common cancer in the US. While strides in screening have been made, there are persistent #disparities in screening amongst racial/ethnic groups. Equity strategies outlined https://t.co/AYoOcJsTI5 https://t.co/IzHDLubvPc

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    Abstract. Oncogenic KRAS (KRAS*) contributes to many cancer hallmarks. In colorectal cancer (CRC), KRAS* suppresses anti–tumor immunity to promote tumor invasion and metastasis. Here, we uncovered that KRAS* transforms the phenotype of carcinoma-associated fibroblasts (CAFs) into lipid–laden CAFs, promoting angiogenesis and tumor progression. Mechanistically, KRAS* activates the transcription factor CP2 (TFCP2) which upregulates the expression of the pro–adipogenic factors BMP4 and WNT5B, triggering the transformation of CAFs into lipid–rich CAFs. These lipid-rich CAFs, in turn, produce vascular endothelial growth factor A (VEGFA) to spur angiogenesis. In KRAS*–driven CRC mouse models, genetic or pharmacological neutralization of TFCP2 reduced lipid-rich CAFs, lessened tumor angiogenesis, and improved overall survival. Correspondingly, in human CRC, lipid-rich CAF and TFCP2 signatures correlate with worse prognosis. This work unveils a new role for KRAS* in transforming CAFs, driving t

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    • Oncogenic #KRAS Drives Lipo-fibrogenesis to Promote #Angiogenesis and #ColonCancer Progression, by Wen-Hao Hsu, @RonDePinho et al. https://t.co/rwDRNyf8od @MDAndersonNews https://t.co/AF2MahRbVi

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    James Casey, acclaimed saxophonist for the Trey Anastasio Band, died Aug. 28 at age 40 after a 2-year battle with colon cancer. Earlier this year, Casey shared his diagnosis and cancer battle at the “Colorectal Cancer in Young Black Americans” webinar event, presented by the Association for Black Gastroenterologists and Hepatologists (ABGH).

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    • 🌟 saxophonist 🎷, patient advocate @JamesCaseySax dies of #coloncancer “His story highlights some of the challenges we [the Black community] face when we are saying what is happening with us," @vgustavemd said. @blackingastro @DrR_Williams https://t.co/UvpoM2oVQN