-
Mashup Score: 20
Johns Hopkins Medicine scientists say their 20-year study of more than 200 people with premature aging syndromes caused by abnormally short telomeres, or shortened repetitive DNA sequences at the ends of chromosomes, may upend long-held scientific dogma and settle conflicting studies about how and whether short telomeres contribute to cancer risk.
Source: medicalxpress.comCategories: General Medicine News, Latest HeadlinesTweet
-
Mashup Score: 0The phospho-docking protein 14-3-3 regulates microtubule-associated proteins in oocytes including the chromosomal passenger Borealin - 2 year(s) ago
Author summary Accurate segregation of chromosomes during cell division is fundamental for genome stability. Chromosome segregation is mediated by the spindle, which is made of dynamic microtubules and associated proteins that regulate microtubule behaviour. How these microtubule-associated proteins are regulated is not well understood. Furthermore, as oocytes have an exceptionally large volume…
Source: journals.plos.orgCategories: Genetics, Latest HeadlinesTweet-
Repton et al show that phospho-docking protein 14-3-3 regulates microtubule-associated proteins in fly oocytes This may provide insights into chromosome mis-segregation in humans, a cause of #infertility #Genetics #chromosomes https://t.co/Arr5HoIVQi
-
-
Mashup Score: 0Translin facilitates RNA polymerase II dissociation and suppresses genome instability during RNase H2- and Dicer-deficiency - 2 year(s) ago
Author summary Human genetic diseases, including cancers, are frequently driven by substantial changes to chromosomes, including translocations, where one arm of a chromosome is exchanged for another. The human nucleic acid binding protein Translin was first identified by its ability to bind to the chromosomal sites at which some of these translocations occur. This resulted in Translin being…
Source: journals.plos.orgCategories: Genetics, Latest HeadlinesTweet-
Gomez-Escobar et al find that human nucleic acid binding protein Translin contributes to minimizing the deleterious #genome destabilizing effects of retaining gene expression machineries on #chromosomes @BangorUni #Genetics #Genomics https://t.co/ejQQjyEqZN
-
-
Mashup Score: 0Heterochiasmy and the establishment of gsdf as a novel sex determining gene in Atlantic halibut - 2 year(s) ago
Author summary Even closely related fish species can have different sex chromosomes, but this turn-over of sex determination systems is poorly understood. Here, we used large-scale genome sequencing to determine the DNA sequence of the Atlantic halibut chromosomes and compared sequencing data from males and females to identify the sex chromosomes. We show that males have much higher gene activity…
Source: journals.plos.orgCategories: Genetics, Latest HeadlinesTweet-
What causes the rapid turn-over of genetic sex determination systems in #fish? Edvardsen et al find that all Atlantic halibut #chromosomes behave similar to sex chromosomes, in that most regions only recombine in one sex #halibut #genetics #genomics https://t.co/W631UCUH8r
-
-
Mashup Score: 1Effects of aneuploidy on cell behaviour and function - Nature Reviews Molecular Cell Biology - 2 year(s) ago
Aneuploidy affects organisms from early development through to aging and is a cause of pregnancy loss and cancer. Recent studies have increased our understanding of its mechanisms and how it can be both beneficial and detrimental to cells and organisms, depending on the karyotype and external cues. These insights shed light on its roles in human pathogenesis and on genome evolution.
Source: NatureCategories: Allergy-Immunology, Latest HeadlinesTweet-
Also in April issue #Review by Rong Li and Jin Zhu discussing how #aneuploidy affects cell function @RongLabOfficial @NUSingapore @JohnsHopkins #chromosomes #genomeinstability https://t.co/sZLRhL3BJ6 https://t.co/fPWWYELIjx
-
-
Mashup Score: 3
By comparing chromosomes of different animal groups scientists at the University of Vienna led by Oleg Simakov and at the University of California made an astonishing discovery: Every animal species has almost the same chromosomal units that appear over and over again—and this has been the case since the first animals emerged about 600 million years ago. Using new principles, human chromosomes…
Source: medicalxpress.comCategories: General Medicine News, Latest HeadlinesTweet-
Animal genomes: #Chromosomes almost unchanged for over 600 million years @ScienceAdvances https://t.co/Pev9EWDoeL
-
-
Mashup Score: 11Effects of aneuploidy on cell behaviour and function - Nature Reviews Molecular Cell Biology - 2 year(s) ago
Aneuploidy affects organisms from early development through to aging and is a cause of pregnancy loss and cancer. Recent studies have increased our understanding of its mechanisms and how it can be both beneficial and detrimental to cells and organisms, depending on the karyotype and external cues. These insights shed light on its roles in human pathogenesis and on genome evolution.
Source: NatureCategories: Allergy-Immunology, Latest HeadlinesTweet-
New #Review by Rong Li and Jin Zhu discussing how #aneuploidy affects cell function @RongLabOfficial @NUSingapore @JohnsHopkins #chromosomes #genomeinstability https://t.co/sZLRhL3BJ6 https://t.co/nlDxMN6e2K
-
-
Mashup Score: 0Deficiency of Polη in Saccharomyces cerevisiae reveals the impact of transcription on damage-induced cohesion - 2 year(s) ago
Author summary The cohesin complex dynamically associates with chromosomes and holds sister chromatids together through cohesion established during replication. This ensures faithful chromosome segregation at anaphase. In budding yeast, DNA double strand breaks also trigger sister chromatid cohesion after replication. This so-called damage-induced cohesion is formed both close to the breaks, and…
Source: journals.plos.orgCategories: Genetics, Latest HeadlinesTweet-
DNA double strand breaks can trigger chromatid cohesion Wu et al study the role of polymerase eta (Polη) in #yeast & show that it's involved in cohesion via regulation of transcription #DNA #Genetics #chromosomes https://t.co/IWPTvUKTKV
-
-
Mashup Score: 40Aneuploidy May Help Tumors Become Resistant to Treatment - 3 year(s) ago
Aneuploidy—when cells have too many or too few chromosomes—may be common in cancer cells because it helps them develop resistance to drugs like chemotherapy and targeted therapies, two new studies suggest. The cancer cells that thrived tended to have the same pattern of extra or missing chromosomes, they found.
Source: National Cancer InstituteCategories: Hem/Onc News and Journals, Latest HeadlinesTweet-
About 90% of #tumors have cancer cells with extra or missing chromosomes. A new NCI-funded study shows that the gain or loss of #chromosomes may actually benefit cancer cells. https://t.co/PjP8xAJ1Ct #CancerResearch @CellPressNews https://t.co/xir4JbtRwv
-
-
Mashup Score: 1NuA4 and SAGA acetyltransferase complexes cooperate for repair of DNA breaks by homologous recombination - 3 year(s) ago
Author summary DNA double-strand breaks (DSBs) are among the most dangerous types of DNA lesions as they can produce genomic instability that leads to cancer and genetic diseases. It is therefore crucial to understand the precise molecular mechanisms used by cells to detect and repair this type of damages. Homologous recombination using sister chromatid as template is the most accurate pathway to…
Source: journals.plos.orgCategories: Genetics, Latest HeadlinesTweet-
New lessons on how double-strand breaks in #DNA are repaired by homologous #recombination: Cheng et al show that recombination-mediated repair requires #enzymes NuA4 and SAGA, which acetylate the structural components of #chromosomes near DNA breaks https://t.co/PvbnlnB3iR
-
A 20-year study may upend long-held theory about #chromosomes and #cancer https://t.co/MA8gfjFgQG