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Mashup Score: 3BHLHE40 drives protective polyfunctional CD4 T cell differentiation in the female reproductive tract against Chlamydia - 2 month(s) ago
Author summary Chlamydia is the leading cause of bacterial sexually transmitted disease worldwide. A better understanding of host immunity to this pathogen is required to develop a protective vaccine. In this study, we demonstrate that a polyfunctional CD4 T cell population capable of producing multiple cytokines (IFN-γ, IL-17A and GM-CSF) is essential for protective immunity against Chlamydia in the female reproductive tract. Moreover, we show that transcription factor Bhlhe40 acts as a key regulator that drives the differentiation of these polyfunctional CD4 T cells. Our findings provide new insights into the features of protective CD4 T cells in the host, which will guide the development of a Chlamydia vaccine.
Source: journals.plos.orgCategories: General Medicine News, Infectious DiseaseTweet
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Mashup Score: 1Elimination of Chlamydia muridarum from the female reproductive tract is IL-12p40 dependent, but independent of Th1 and Th2 cells - 2 month(s) ago
Author summary The mechanism that CD4 T cells use to mediate clearance of Chlamydia infection in the female reproductive tract remains unclear. Contrary to prevailing ideas, previous work from our lab demonstrated that the Th1 subset characterized by T-bet expression is not required for clearance. Here, we explore other T helper subsets and determine that Th2 cells are likewise not required while Th17 cells contribute to the early phase of infection clearance. Ultimately, the cytokine subunit IL-12p40 plays a substantial role in driving an effective CD4 T cell response that is not neatly defined by canonical CD4 subset Th1, Th2, or Th17 identity. Vaccine development thus should focus on this IL-12p40-driven CD4 T cell response rather than relying on markers of classical T helper subsets.
Source: journals.plos.orgCategories: General Medicine News, Infectious DiseaseTweet
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Mashup Score: 4VIDEO: What to know about CDC’s draft guidance on doxy-PEP - 6 month(s) ago
BOSTON — In this video from IDWeek, Annie Luetkemeyer, MD, discusses the CDC’s pending recommendations for prescribing doxycycline as post-exposure prophylaxis for sexually transmitted infections.
Source: www.healio.comCategories: Infectious Disease, Latest HeadlinesTweet
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Mashup Score: 0Design of a novel multiepitope vaccine against Chlamydia pneumoniae using the extracellular protein as a target - 6 month(s) ago
Scientific Reports – Design of a novel multiepitope vaccine against Chlamydia pneumoniae using the extracellular protein as a target
Source: www.nature.comCategories: Infectious Disease, Latest HeadlinesTweet
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Mashup Score: 0
An IDSA Reading Room selection
Source: www.medpagetoday.comCategories: General Medicine News, Latest HeadlinesTweet
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Mashup Score: 0
‘Seek, test, and treat’ program yields clinical benefits without a hefty price-tag
Source: www.medpagetoday.comCategories: General Medicine News, Latest HeadlinesTweet
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Mashup Score: 0Doxycycline Preferred for the Treatment of Chlamydia - 1 year(s) ago
Letter
Source: www.aafp.orgCategories: General Medicine Journals and Societies, Latest HeadlinesTweet
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Mashup Score: 0Binx IO Point-of-Care Test for Chlamydia trachomatis and Neisseria gonorrhoeae Infections - 1 year(s) ago
Binx IO is a cartridge-based test with a Clinical Laboratory Improvement Amendment (CLIA) waiver that detects Chlamydia trachomatis and Neisseria gonorrhoeae infections in patients with or without symptoms.1 The molecular assay is performed by clinicians using vaginal swabs or male urine specimens. Results are available in 30 minutes, allowing for testing and treatment in a single visit.1
Source: www.aafp.orgCategories: General Medicine Journals and Societies, Latest HeadlinesTweet
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Mashup Score: 1
What can the individual do, especially those who are underserved, to protect themselves against sexually transmitted infections, including chlamydia, gonorrhea, and syphilis, and complicated with monkeypox.
Source: Infection Control TodayCategories: Infectious Disease, Latest HeadlinesTweet
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Mashup Score: 0
What can the individual do, especially those who are underserved, to protect themselves against sexually transmitted infections, including chlamydia, gonorrhea, and syphilis, and complicated with monkeypox.
Source: Infection Control TodayCategories: Infectious Disease, Latest HeadlinesTweet
Dr. Lin-Xi Li and scientists at @uamshealth 🔎 investigated the role of Bhlhe40 in protective T cell responses to the intracellular bacterium #Chlamydia in the female reproductive tract. 📖 @PLOSPathogens | https://t.co/g1UU9WdSiG https://t.co/fSduYpTYEx