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Mashup Score: 4Multimodal single-cell analyses reveal mechanisms of perianal fistula in diverse patients with Crohn’s disease - 2 hour(s) ago
Levantovsky et al. profile perianal fistula and colorectal tissues from Crohn’s disease, integrating multiomic single-cell and in vitro models. The discovery of unique fistula fibroblasts, distinct monocyte differentiation in individuals of African ancestry, and key transcription factor binding events provides insight into mechanisms that underlie disparities in fistula prevalence.
Source: www.cell.comCategories: General Medicine News, General HCPsTweet
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Mashup Score: 1A bacterial expression cloning screen reveals single-stranded DNA-binding proteins as potent desicco-protectants - 4 hour(s) ago
Desiccation is a harsh stress that kills most cells and organisms. Hibshman et al. used an expression-cloning approach to screen for tardigrade proteins that could improve bacterial desiccation survival. They found that mitochondrial single-stranded DNA-binding proteins can significantly improve desiccation survival—an effect that relies on their ability to bind DNA.
Source: www.cell.comCategories: General Medicine News, General HCPsTweet-
A bacterial expression cloning screen reveals single-stranded DNA-binding proteins as potent desicco-protectants. A study by @JonHibsh & colleagues in @CellReports #CellBio2024 https://t.co/j8wK0NDh5S
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Mashup Score: 10How to build the virtual cell with artificial intelligence: Priorities and opportunities - 6 hour(s) ago
Advances in AI and omics enable the creation of AI virtual cells (AIVCs)—multi-scale, multimodal neural network models that simulate molecules, cells, and tissues across diverse states. This vision outlines their design and collaborative development, promising to transform biological research through high-fidelity simulations, accelerating discoveries, and fostering interdisciplinary open science collaborations.
Source: www.cell.comCategories: General Medicine News, General HCPsTweet-
Out now in @CellCellPress! How to build the virtual cell with artificial intelligence: Priorities and opportunities. @Prof_Lundberg @StephenQuake @jure Aviv Regev @Tkaraletsos @_bunnech @YanayRosen @yusufroohani #CellBio2024 https://t.co/2HNLhjTVWL
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Mashup Score: 1Myeloid-T cell interplay and cell state transitions associated with checkpoint inhibitor response in melanoma - 8 hour(s) ago
Schlenker et al. generate a high-resolution immune cell atlas of metastatic melanoma tumors and peripheral blood using single-cell RNA sequencing. They relate the baseline immune cell contexture to response to checkpoint inhibitor therapy, characterizing distinct myeloid, T, and NK cell state transitions and putative interactions across response classes.
Source: www.cell.comCategories: General Medicine News, General HCPsTweet-
Myeloid-T cell interplay and cell state transitions associated with checkpoint inhibitor response in melanoma. A collaboration btw @Roche & @UZH_en @MedCellPress #CellBio2024 https://t.co/ELOQbf1u6K
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Multimodal single-cell analyses reveal mechanisms of perianal fistula in diverse patients with Crohn’s disease. @JudyCho7 & co-workers report in @MedCellPress #CellBio2024 https://t.co/PyVCtTI5DK