-
Mashup Score: 2
BACKGROUND: Heart failure is typical in the elderly. Metabolic remodeling of cardiomyocytes underlies inexorable deterioration of cardiac function with aging: glycolysis increases at the expense of o
Source: www.ahajournals.orgCategories: Cardiology News and Journals, Latest HeadlinesTweet
-
Mashup Score: 3
BACKGROUND: Efferocytosis is an activity of macrophages that is pivotal for the resolution of inflammation in hypertension. The precise mechanism by which macrophages coordinate efferocytosis and int
Source: www.ahajournals.orgCategories: Cardiology News and Journals, Latest HeadlinesTweet-
Gao et al. demonstrated that effective clearance of apoptotic #cardiomyocytes through #efferocytosis is critical for resolving cardiac #inflammation. Learn how mitochondrial iron disorder can lead to proinflammatory #macrophage activation https://t.co/6Mmyo3efqT https://t.co/yS4nVcAWtc
-
-
Mashup Score: 0
BACKGROUND: Diastolic dysfunction is central to diseases such as heart failure with preserved ejection fraction and hypertrophic cardiomyopathy (HCM). However, therapies that improve cardiac relaxati
Source: www.ahajournals.orgCategories: Cardiology News and Journals, Latest HeadlinesTweet-
Algül & colleagues screened 157 different kinase inhibitors in adult mouse #cardiomyocytes and found that inhibition of the #EGFR/#IGFR signaling can promote heart muscle relaxation in #HCM. Learn more at https://t.co/bMcauLsVgB @s_algl @diederik_kuster https://t.co/ltlglDT4R6
-
-
Mashup Score: 3Interaction of Filamin C With Actin Is Essential for Cardiac Development and Function - 8 month(s) ago
BACKGROUND: FLNC (filamin C), a member of the filamin family predominantly expressed in striated muscles, plays a crucial role in bridging the cytoskeleton and ECM (extracellular matrix) in cardiomyo
Source: www.ahajournals.orgCategories: Cardiology News and Journals, Latest HeadlinesTweet-
Zhou et al identified the essential AA residues in Filamin C (#FLNC) that are necessary for #actin binding. Loss of FLNC-actin binding in embryonic #cardiomyocytes leads to developmental defects & embryonic lethality. Learn more at https://t.co/Oj5OtSVH7w @tongbinwu https://t.co/LDcGJknLLH
-
-
Mashup Score: 4Stretch Harmonizes Sarcomere Strain Across the Cardiomyocyte - 9 month(s) ago
BACKGROUND: Increasing cardiomyocyte contraction during myocardial stretch serves as the basis for the Frank-Starling mechanism in the heart. However, it remains unclear how this phenomenon occurs re
Source: www.ahajournals.orgCategories: Cardiology News and Journals, Latest HeadlinesTweet-
Li et al show that #cardiomyocytes exhibit non-uniform #sarcomere strain, as short sarcomeres are stretched by their longer neighbors. Cell lengthening harmonizes sarcomere strain. Learn more https://t.co/W2c5GkfZvx https://t.co/9tVqaenyjj
-
-
Mashup Score: 1
Background: Ischemic heart disease is a major global public health challenge, and its functional outcomes remain poor. Lysine crotonylation (Kcr) was recently identified as a post-translational histo
Source: Circulation ResearchCategories: Cardiology News and Journals, Latest HeadlinesTweet-
Cai & colleagues found that extensive #Kcr of cytoskeletal & #mitochondrial proteins is a major response to cardiac #I/R injury. Enhanced Kcr preserves myocardial function by protecting #cardiomyocytes. Learn more at https://t.co/kC2pvN8uNl https://t.co/R4aE1H0DyY
-
-
Mashup Score: 0
June 29, 2022 — While lower vertebrates can repair their adult hearts after a heart attack, mammals — including humans — cannot. The ability to regenerate dead muscle tissue in mammalian hearts disappears just a few days after birth because the heart muscle cells, called cardiomyocytes, exit the cell cycle. After that, all growth of the heart comes from enlargement of existing cells, not from…
Source: DAICCategories: Cardiologists, Latest HeadlinesTweet-
@DAICeditor Single-nucleus RNA-sequencing in a newborn #pig model showed increased cell cycle activity and proliferation in #cardiomyocytes, which helped #remuscularize the left ventricle after experimental #heartattack: https://t.co/puZPiyWEiN
-
-
Mashup Score: 2
AbstractAims. Genetic dilated cardiomyopathy (DCM) is a leading cause of heart failure. Despite significant progress in understanding the genetic aetiologies of
Source: OUP AcademicCategories: Cardiologists, Latest HeadlinesTweet-
Serine biosynthesis as a novel therapeutic target for DCM Phenotypic screening of iPSC-derived #cardiomyocytes suggests that modulation of serine biosynthesis pathway may be a potential novel therapeutic target for genetic #DCM. https://t.co/7J4eqLcYiA #EHJ @ESC_Journals https://t.co/ipkKUxkgwm
-
-
Mashup Score: 2Microscopy-based cellular contractility assay for adult, neonatal, and hiPSC cardiomyocytes: STAR Protocols - 2 year(s) ago
Summary This protocol provides instructions to acquire high-quality cellular contractility data from adult, neonatal, and human induced pluripotent stem cell-derived cardiomyocytes. Contractility parameters are key to unravel mechanisms underlying cardiac pathologies, yet difficulties in acquiring data can compromise measurement accuracy and reproducibility. We provide…
Source: star-protocols.cell.comCategories: General Medicine News, Latest HeadlinesTweet-
Online in @STARProtocols: Check out this #protocol from Dr. Silvia Guatimosim's lab @sergio_scalzo @ufmg describing a microscopy-based cellular contractility assay for adult, neonatal, and #hiPSC #cardiomyocytes: https://t.co/UEpV3TYm0l Featuring 5 method videos! https://t.co/V7LaNNRkNy
-
-
Mashup Score: 1
To receive upcoming Frontiers announcements, register/subscribe here: https://tinyurl.com/CVIannouncements For interested graduate students, medical students, postdocs, residents, and fellows – Meet and chat with our Frontiers speakers for an Early Career Investigators Session. Sign-Up Sheet: https://tinyurl.com/ECI-Fall21
Source: Zoom Video CommunicationsCategories: Cardiologists, Latest HeadlinesTweet-
Please join @StanfordCVI seminar on Tue 3/22 at 1pm PST by @ChulanKwonLab @HopkinsHeart @JHUBME on maturation of #iPSC #cardiomyocytes Zoom: https://t.co/929BNOBmSR PW: 294085 @StanfordDeptMed @Stanford_ChEMH @vascularbiology @StanCVFellows @ECI_ISHR @BCVSearlyCareer @ISSCR https://t.co/zxDyFsNPca
-
Serio et al found that epigenetically regulated modification of enhancer activity drives #metabolic changes in aging #cardiomyocytes, leading to decreased #CardiacFunction. Learn more at https://t.co/qXKeLsTWyc @xtinapag @gcondorelli @Michele_Miragol https://t.co/6vsqYfRpoh