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Mashup Score: 0
August 17, 2022 — A study carried out by scientists at the Centro Nacional de Investigaciones Cardiovasculares (CNIC) and led by Dr. Guadalupe Sabio has identified a key role for the MKK3/6–p38γ/δ signaling pathway in the development of cardiac hypertrophy. The results, published in the journal eLife, suggest that inhibition of p38γ/δ could be a useful therapeutic strategy for diseases such as…
Source: DAICCategories: Cardiologists, Latest HeadlinesTweet
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Mashup Score: 2MKK6 deficiency promotes cardiac dysfunction through MKK3-p38γ/δ-mTOR hyperactivation - 2 year(s) ago
Lack of cardiac MKK6 results in premature death with the development of heart hypertrophy and cardiac dysfunction in aging.
Source: eLifeCategories: General Medicine News, Latest HeadlinesTweet
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Mashup Score: 9Discovery could herald new treatment for cardiac hypertrophy - 2 year(s) ago
Scientists have identified an important new mechanism that causes the heart’s muscle to thicken, which markedly increases the risk of irregular heart rhythms and heart failure.
Source: medicalxpress.comCategories: General Medicine News, Latest HeadlinesTweet
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Mashup Score: 3
Background: Pathological cardiac hypertrophy is one of the leading causes of heart failure with highly complicated pathogeneses. The E3 ligase TRIM16 (tripartite motif–containing protein 16) has been
Source: Circulation ResearchCategories: Cardiology News and Journals, Latest HeadlinesTweet
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Mashup Score: 1
Background: Transcriptional remodeling is known to contribute to heart failure (HF). Targeting stress-dependent gene expression mechanisms may represent a clinically relevant gene therapy option. We
Source: Circulation ResearchCategories: Cardiology News and Journals, Latest HeadlinesTweet
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Mashup Score: 4
Rationale: RBPs (RNA-binding proteins) play critical roles in human biology and disease. Aberrant RBP expression affects various steps in RNA processing, altering the function of the target RNAs. The
Source: Circulation ResearchCategories: Cardiology News and Journals, Latest HeadlinesTweet
@DAICeditor @cnic #p38 proteins regulate many processes, and their #dysregulation is linked to several #diseases, making them a promising target for drug development: https://t.co/MlwM18CXf4 #cardiachypertrophy