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    Home > mCRPC > Is Abiraterone Acetate More Effective With or Without Cabazitaxel for mCRPC? Gene expression profiling has shown that metastatic castration-resistant prostate cancer (mCRPC) cells are deficient in retinoblastoma proteins (RB), resulting in a hypersensitivity to taxanes such as cabazitaxel. Preclinical studies have found that cabazitaxel has superior antitumor efficacy compared with docetaxel for mCRPC. A phase 2, randomized trial i nvestigated the potential efficacy of abiraterone acetate/pre

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    • Is abiraterone more effective with cabazitaxel for mCRPC? #mCRPC cells are deficient in retinoblastoma proteins, resulting in a hypersensitivity to taxanes such as #cabazitaxel, which has demonstrated superior antitumor efficacy for mCRPC. Learn more: https://t.co/JlCQDivLf3 https://t.co/75s9Qts0bY

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    In the first of a 2-part article series, Joshua Lang, MD, and live event participants discuss how the addition of cabazitaxel to the treatment of patients with metastatic castration-resistant prostate cancer can improve outcomes despite some challenging adverse events.

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    • This article features a discussion with Joshua Lang, MD, on the addition of #cabazitaxel for the treatment of patients with #mCRPC. #pcsm | @JoshLangMD @UWMedicine https://t.co/dATfwJnKnm https://t.co/6depYvu5X3

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    During a Targeted Oncology case-based roundtable event, Atish D. Choudhury, MD, PhD, discussed with participants the use of cabazitaxel in a patient with metastatic castration-resistant prostate cancer who did not tolerate docetaxel.

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    • During a Targeted Oncology case-based roundtable event, Atish D. Choudhury, MD, PhD, discussed the use of #cabazitaxel in a patient with metastatic castration-resistant prostate cancer who did not tolerate docetaxel. #pcsm #mcrpc | @DanaFarber https://t.co/yXCXWalUEH

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    During a live virtual event, Emmanuel S. Antonarakis, MD, discussed the results of the CARD trial of cabazitaxel for patients with metastatic castration-resistant prostate cancer. This is part 1 of 2 articles based on this event.

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    • PART 1: During a live virtual event, Emmanuel S. Antonarakis, MD, discussed the results of the CARD trial of #cabazitaxel for patients with metastatic castration-resistant prostate cancer. @UMNCancer #mCRPC #pcsm https://t.co/MD5WFOZKoG

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    The CARD study was a head-to-head comparison of cabazitaxel chemotherapy versus either abiraterone or enzalutamide in mCRPC patients who had been exposed to one series of the docetaxel chemotherapy cycle and the alternative AR-targeted agents. There was a 30% reduction in the risk of death by cabazitaxel chemotherapy. This data was presented at the 2019 ESMO meeting by Ronald de Wit, MD, Ph.D….

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    • Real-world evidence for patients with #mCRPC treated with #cabazitaxel. Ronald de Wit, MD, PhD @ErasmusMC joins @CaPsurvivorship @DanaFarber highlighting the posthoc analysis completed in a large real-world dataset within the #CARD-eligible population > https://t.co/aJ7zP7sEOm https://t.co/s7HbL6ricU

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    The CARD study was a head-to-head comparison of cabazitaxel chemotherapy versus either abiraterone or enzalutamide in mCRPC patients who had been exposed to one series of the docetaxel chemotherapy cycle and the alternative AR-targeted agents. There was a 30% reduction in the risk of death by cabazitaxel chemotherapy. This data was presented at the 2019 ESMO meeting by Ronald de Wit, MD, Ph.D….

    Tweet Tweets with this article
    • Real-world evidence for patients with #mCRPC treated with #cabazitaxel. Ronald de Wit, MD, PhD @ErasmusMC joins @CaPsurvivorship @DanaFarber highlighting the posthoc analysis completed in a large real-world dataset within the #CARD-eligible population > https://t.co/aJ7zP7sEOm https://t.co/JFK6o4iyMF