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Mashup Score: 13Hope for STAb-T cell therapy for myeloma - 2 month(s) ago
Spanish researchers have announced the development of a new cell-based immunotherapy for multiple myeloma. The treatment is based on STAb-T cells – engineered T cells secreting T cell engager (TCE) antibodies. The team claim their latest laboratory studies suggest they could be more effective than existing CAR-T treatment. The scientists say their process is similar to CAR-T, in that T cells are…
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Mashup Score: 6Call for action on ‘blood deserts’ - 2 month(s) ago
The world needs to adopt military style responses to shortages of blood in areas deemed to be ‘blood deserts’, according to a group of senior doctors. The Blood D.E.S.E.R.T. Coalition – Delivery via Emerging Strategies for Emergency Remote Transfusion – has set out its proposals in the journal Lancet Global Health, warning that more than half the world’s population does not have access to…
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Mashup Score: 17New breakthrough in leukaemia-HIV double treatment case - 2 month(s) ago
A patient, aged 68, has become the oldest to achieve remission for both leukaemia and HIV through a stem cell transplant, it has been announced. The patient, named as Paul Edmonds, is thought to be the fifth known patient to experience a double cure from a transplant, after being given donor cells known to be resistant to HIV because they carried the genetic mutation homozygous CCR5-Δ32. The…
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Mashup Score: 7Finding the best hypertension treatment for patients taking BTKi - 2 month(s) ago
A new study has shed light on the optimal treatment for high blood pressure in patients taking ibrutinib or related drugs. The type of treatment may depend on whether the hypertension is pre-existing or new onset, according to the first study of its kind, reported in Blood Advances. The team of US researchers was led by Dr Mazyar Shadman from The Fred Hutchinson Cancer Center in Seattle, USA….
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Mashup Score: 4Lipid-based classification of AML resistance risk - 2 month(s) ago
Researchers have announced a new technique which in the future could help classify acute myeloid leukaemia (AML) and identifying high-risk patients, based on analysis of sphingolipids. Reporting in Blood Advances, the researchers at the University of Virginia, USA, measured the levels of various families of sphingolipids, which are known to play a key role in resistance to treatment. By using…
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Mashup Score: 5Children’s cancer taskforce launched - 2 month(s) ago
A new taskforce will provide an extra focus on the improvement of care for children and young people with cancer, the Government announced last week. The taskforce is to be chaired by Dame Caroline Dinenage, and will involve charities including Cancer Research UK, Teenage Cancer Trust, Young Lives vs Cancer, and the Children’s Cancer and Leukaemia Group. It is expected to push for improved access…
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Mashup Score: 8AI recognises mutations from AML bone marrow images - 3 month(s) ago
A method based on artificial intelligence (AI) can be used to predict genetic features of acute myeloid leukaemia (AML), according to a German study. A team of IT specialists and physicians at the University of Münster and the University Hospital Münster used AI analysis on high-resolution microscopic images of bone marrow smears. This could enable clinicians to make decisions about precise…
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Mashup Score: 3RNA sequencing 'promising' for B-ALL paediatric patients - 3 month(s) ago
RNA sequencing is a promising and clinically applicable technology for improving diagnosis and treatment of paediatric B-acute lymphoblastic leukaemia (B-ALL), researchers have reported. The study of RNA sequencing (RNA-Seq) by researchers at the Children’s Hospital Los Angeles, and the City of Hope institute, California has been published in The Journal of Molecular Diagnostics. In a pilot…
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Mashup Score: 5Inherited genetic variants’ role in MPNs - 3 month(s) ago
British scientists have found a relationship between cancer-driving genetic mutations and inherited genetic variants in myeloproliferative neoplasms (MPNs). Researchers from the Wellcome Sanger Institute, the University of Cambridge, and collaborators, combined several comprehensive data sets to understand the impact of both cancer-driving spontaneous mutations and inherited genetic variation on…
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Mashup Score: 9Promising results for CAR-NK cells for B-cell cancers - 3 month(s) ago
Chimeric antigen receptor (CAR) natural killer (NK) cell therapy that targets the CD19 antigen has yielded promising results for patients with a range of B-cell malignancies. Researchers from The University of Texas MD Anderson Cancer Center, USA, said they were pleased with the results of a phase I/II trial of 37 patients with relapsed or refractory B-cell malignancies who were treated with cord…
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Spanish researchers have announced the development of a new cell-based immunotherapy for multiple myeloma. Read the latest #BSHNews story here: https://t.co/6XIQnn4sjc https://t.co/wqMS9GVopI