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Mashup Score: 21
Journal of Neuro-Oncology – Genomic alterations are fundamental for molecular-guided therapy in patients with breast and lung cancer. However, the turn-around time of standard next-generation…
Source: link.springer.comCategories: General Medicine News, Onc News and JournalsTweet
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Mashup Score: 7MSK Research Highlights, August 24, 2023 - 8 month(s) ago
New MSK research suggests a method for revealing DNA repair “scars” could help make treatment decisions in BRCA1- and BRCA2-deficient cancers; modified a bacteria-made compound to target mutant KRAS-driven cancers; and shed new light on brain metastasis in non-small cell lung cancer.
Source: www.mskcc.orgCategories: Hem/Onc News and Journals, Latest HeadlinesTweet-
MSK researchers are making strides against #cancer every day. Check out some of their latest discoveries in BRCA-deficient cancers, natural product drug discovery against #KRAS, & #BrainMets in #NSCLC, published in @Nature, @ScienceMagazine & @NatureComms. https://t.co/RmRG6ekEJT
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Mashup Score: 0Comparing the Addition of Radiation Either Before or After Surgery for Patients With Brain Metastases - Full Text View - ClinicalTrials.gov - 8 month(s) ago
Comparing the Addition of Radiation Either Before or After Surgery for Patients With Brain Metastases – Full Text View.
Source: classic.clinicaltrials.govCategories: Hem/Onc News and Journals, Latest HeadlinesTweet-
#TrialTuesday: Dr. Wenyin Shi is leading a phase III trial comparing stereotactic radiosurgery, a type of #RadiationTherapy, before or after surgery to treat patients whose cancer has spread - or metastasized - to the brain. #RadOnc #BrainMets @NRGonc 🔗https://t.co/uwISg05GlX https://t.co/qEjblj8P3P
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Mashup Score: 2Stereotactic Radiosurgery Before Resection of Brain Metastases From Solid Tumors - The ASCO Post - 9 month(s) ago
In a study reported in JAMA Oncology, Prabhu et al identified outcomes and associated risk factors among patients receiving stereotactic radiosurgery (SRS) prior to resection of brain metastases from solid tumors. The study involved data from an international multicenter cohort (Preoperative Radiosurgery for Brain Metastases–PROPS-BM). The current study cohort included 404 patients from eight sites in the United States and Australia who were treated between 2005 and 2021, with most being treated since
Source: ascopost.comCategories: Hem/Onc News and Journals, Latest HeadlinesTweet-
Stereotactic Radiosurgery Before Resection of Brain Metastases From Solid Tumors https://t.co/zb2N7Q1CTb #radonc #oncology #brainmets
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Mashup Score: 0Adagrasib Shows Activity in Patients With KRAS G12C Mutated NSCLC and Untreated Brain Metastases - The ASCO Post - 10 month(s) ago
By The ASCO Post Staff Posted: 6/20/2023 9:27:00 AM Last Updated: 6/20/2023 11:48:51 AM The KRAS G12C inhibitor adagrasib may be effective at suppressing cancer growth not only within the lungs but also in brain metastases for patients with KRAS G12C–mutated non–small cell lung cancer (NSCLC), according to a…
Source: ascopost.comCategories: Hem/Onc News and Journals, Latest HeadlinesTweet-
Adagrasib Shows Activity in Patients With KRAS G12C–Mutated NSCLC and Untreated Brain Metastases https://t.co/EbG7puVxlv #LCSM #lungcancer #brainmets #oncology
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Mashup Score: 0
By The ASCO Post Staff Posted: 6/3/2023 12:06:00 PM Last Updated: 6/3/2023 12:59:53 PM In a phase II clinical trial, investigators found that 42% of patients with brain metastases benefited from treatment with the immune checkpoint inhibitor pembrolizumab, with 7 of the 57 patients in the trial surviving for…
Source: ascopost.comCategories: Hem/Onc News and Journals, Latest HeadlinesTweet-
Is Pembrolizumab Effective in Patients With Brain Metastases? https://t.co/N2t6h2wPBa #ASCO23 #brainmets #immunotherapy #oncology
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Mashup Score: 1Survival in Patients With Brain Metastases Limited or Stable Extracranial Disease - The ASCO Post - 1 year(s) ago
By Matthew Stenger Posted: 3/1/2023 10:12:00 AM Last Updated: 3/1/2023 10:22:16 AM In a systematic review and meta-analysis reported in JAMA Network Open, Li et al found that patients with intracranial metastatic disease in the context of limited or stable extracranial disease (IMD-SE) secondary to any…
Source: ascopost.comCategories: Hem/Onc News and Journals, Latest HeadlinesTweet-
Survival in Patients With Brain Metastases: Limited or Stable Extracranial Disease https://t.co/cqdg4lNWIN #cancer #brainmets #oncology
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Mashup Score: 2Long-Term Quality-of-Life and Cognition Outcomes in Patients Receiving SRS vs WBRT for Resected Brain Metastasis - The ASCO Post - 1 year(s) ago
By Matthew Stenger Posted: 11/22/2022 11:07:00 AM Last Updated: 11/22/2022 3:21:43 PM In an analysis from a Canadian/U.S. phase III trial (Alliance N107C/CEC.3) reported in JAMA Oncology, Palmer et al found that use of stereotactic radiosurgery (SRS) vs whole-brain radiotherapy (WBRT) among patients who had…
Source: ascopost.comCategories: Hem/Onc News and Journals, Latest HeadlinesTweet-
Long-Term Quality-of-Life and Cognition Outcomes in Patients Receiving SRS vs WBRT for Resected Brain Metastasis https://t.co/DcZ0xgwK1E #radonc #cancer #brainmets #oncology
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Mashup Score: 0Comparing Pre-Operative Versus Post-Operative Single and Multi-Fraction Stereotactic Radiotherapy for Patients with Resectable Brain Metastases - 1 year(s) ago
Brain metastases are a cause of substantial morbidity and mortality for cancer patients. Whole brain radiation therapy (WBRT) plus surgery is a historical standard that has been shown to improve overall survival (OS) and local control for patients with brain metastases [1]. Adjuvant WBRT after surgical resection of a brain metastasis, compared to surgery alone, has been shown to reduce the risk…
Categories: Hem/Oncs, Latest HeadlinesTweet-
If you’re not pre-opping your resection-indicated brain mets, it’s time to start reconsidering! Great work by one of our outstanding residents, Dr Haley Perlow & @joshuapalmermd in assembling this data #srs #brainmets #StopLMD https://t.co/KwckSDJHrZ
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Mashup Score: 2Local control of brain metastases with osimertinib alone in patients with EGFR-mutant non-small cell lung cancer - Journal of Neuro-Oncology - 2 year(s) ago
Purpose Although osimertinib has excellent intracranial activity in metastatic non-small cell lung cancer (NSCLC) with exon 19 deletion or L858R EGFR alterations, measures of local control of brain metastases are less well-reported. We describe lesion-level outcomes of brain metastases treated with osimertinib alone. Methods We retrospectively reviewed patients with EGFR-mutant NSCLC with…
Source: SpringerLinkCategories: Hem/Onc News and Journals, Latest HeadlinesTweet-
Though patients with EGFR-mutant #NSCLC #brainmets have good response to osimertinib, over 10% of mets will progress at 1 year. Check out this recent study from @StanfordNsurg regarding rates of local recurrence based on initial response to osimertinib: https://t.co/PLw0mZWT3Q https://t.co/Hme0zTFABd
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Arjuna et al. evaluated cell free total nucleic acids from CSF of patients with lung and breast #brainmets to identify targetable mutations with a turn around time < 24 hrs. @AntonioDonoMD @PavelPichardoMD @RoyRiascosMD @EsquenaziMD @leoballester https://t.co/24b0GqWRvT https://t.co/XXTfHWTqJA