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Mashup Score: 6Structure-Aided Development of Small-Molecule Inhibitors of ENPP1, the Extracellular Phosphodiesterase of the Immunotransmitter cGAMP - 3 year(s) ago
As the dominant hydrolase of the immunotransmitter cGAMP, the extracellular enzyme ENPP1 dampens the anti-cancer immune response. Carozza et al. have solved the crystal structure of ENPP1 in complex with a lead inhibitor, followed by structure-activity relationship studies. The resulting potent and specific extracellular ENPP1 inhibitor delays tumor growth in mice.
Source: Cell Chemical BiologyCategories: General Medicine News, Latest HeadlinesTweet
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Mashup Score: 2
Visualization of nuclear translocation of HIV-1 capsids by 3D correlative fluorescence light and electron microscope, combined with cryoelectron tomography, demonstrates that nuclear pore complexes in infected T cells are sufficiently dilated to allow cone-shaped HIV-1 capsids to pass through.
Source: CellCategories: General Medicine News, Latest HeadlinesTweet-
Visualization of #nuclear translocation of HIV-1 capsids demonstrates that nuclear pore complexes in #infected #Tcells are sufficiently dilated to allow the passage of these cone-shaped capsids https://t.co/0J9TjWcgWX #bps2021 https://t.co/uFmQKCS4sZ
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Mashup Score: 6
X-ray structures of the hantavirus surface glycoprotein lattice reveal a built-in mechanism controlling envelope glycoprotein membrane insertion and provide important information for development of immunogen protection against these deadly viruses.
Source: CellCategories: General Medicine News, Latest HeadlinesTweet-
The #hantavirus surface #glycoprotein lattice and its #fusion control mechanism. https://t.co/8vlx12RMvF @institutpasteur #bps2021 https://t.co/XeP7kBJBLW
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Mashup Score: 5Structures of FHOD1-Nesprin1/2 complexes reveal alternate binding modes for the FH3 domain of formins - 3 year(s) ago
Nuclear movement depends on LINC complexes: physical, nucleo-cytoplasmic connections across the nuclear envelope. Lim et al. employ crystallographic, biochemical, and cell biological tools to reveal how Nesprin-1 and -2, KASH proteins of the LINC complex, interact with cytosolic FHOD1 to connect to actin cables.
Source: StructureCategories: General Medicine News, Latest HeadlinesTweet-
In @Structure_CP by Lim et al. and Thomas Schwartz of @MIT describe how nesprin-1 and-2, #KASH #proteins of the LINC complex, interact with cytosolic FHOD1 to connect to actin cables. https://t.co/xm0foXQ6yX #bps2021
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Mashup Score: 7Catalytic Nucleic Acids: Biochemistry, Chemical Biology, Biosensors, and Nanotechnology - 3 year(s) ago
Chemistry; Biochemistry; Biochemistry Applications; Enzymology; Biomolecules; Nanotechnology
Source: iScienceCategories: General Medicine News, Latest HeadlinesTweet-
RNA and DNA don't just carry genetic information, they can also be enzymes. They power applications in chemistry, nanotechnology and materials @bionaloo @WaterlooSci @WINano #BPS21 https://t.co/vTrHl8axwF #bps2021
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Mashup Score: 1
Super-resolution microscopy, and specifically single-molecule localization microscopy (SMLM), is becoming a transformative technology for cell biology, as it allows the study of cellular structures with nanometer resolution. Here, we review a wide range of data analyses approaches for SMLM that extract quantitative information about the distribution, size, shape, spatial organization, and…
Source: Trends in Cell BiologyCategories: General Medicine News, Latest HeadlinesTweet-
"Quantitative data analysis in single molecule localization microscopy" from @embl @TrendsCellBio #bps2021 https://t.co/EGzoZoOTcu
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Mashup Score: 1A Single-Molecule Surface-Based Platform to Detect the Assembly and Function of the Human RNA Polymerase II Transcription Machinery - 3 year(s) ago
Park et al. develop optimized surface preparation procedures for single-molecule experiments. The increased biocompatibility achieved enables visualizing the assembly and function of a large, multi-component molecular machinery, the human RNA Polymerase II Transcription Pre-Initiation Complex, on a natural promoter, at the single-molecule level.
Source: StructureCategories: General Medicine News, Latest HeadlinesTweet-
A Resource article @Structure_CP! A Single-Molecule Surface-Based Platform for Detecting the Assembly and Function of the Human RNA Polymerase II Transcription Machinery. https://t.co/jfwezjBgGS #bps2021
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Mashup Score: 1Issue: Cell Chemical Biology - 3 year(s) ago
Chemical Tools in Biological DiscoveryEranthie WeerapanaWe are excited to welcome you to our special issue on Chemical Tools in Biological Discovery. The past few decades have given rise to exciting developments in the field of chemical biology. Advancements in biochemical techniques and analytical instrumentation, the ability to collect and access large amounts of “big omics data” (including…
Source: www.cell.comCategories: General Medicine News, Latest HeadlinesTweet-
A recent special issue in @CellChemBiol, #Chemical #Tools in #Biological #Discovery. Check it out at: https://t.co/PECQFpETGa #bps2021
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Mashup Score: 2Cell Press: Biophysical Reports - 3 year(s) ago
Biophysical Reports—the newest addition of the Biophysical Society family and a Cell Press partner journal—is a high-quality, forward-looking gold open access (OA) publishing option for the research community. We help you advance biophysics by making it easier for specialists and generalists to share new insights into experimental data or new technologies and methodologies….
Source: www.cell.comCategories: General Medicine News, Latest HeadlinesTweet-
Biophysical Reports is open for infinite possibilities. Have new insights into experimental data or new technologies and methodologies? Submit your #biophysics research. #bps2021 https://t.co/9hDAYNIbZ8 https://t.co/nM3mIXkda7
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Mashup Score: 1CRISPR/Cas12a-mediated labeling of MET receptor enables quantitative single-molecule imaging of endogenous protein organization and dynamics - 3 year(s) ago
Biochemistry; Molecular Biology; Biophysics; Biological Sciences Research Methodologies
Source: iScienceCategories: General Medicine News, Latest HeadlinesTweet-
CRISPR/Cas12a based labelling for endogenous receptor visualisation by super resolution techniques, from Heilemann lab @GoetheUni #CRISPR #SMLM #BPS21 https://t.co/sETe9OGHWz #bps2021 https://t.co/Awsr89wgtQ
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At @CellChemBiol, Lingyin Li lab @Stanford CheME) developed potent inhibitors of ENPP1, the extracellular phosphodiesterase of the immunotransmitter cGAMP, that delays tumor growth in a breast cancer model. https://t.co/IetF9knnhy #bps2021