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    Single-cell RNA sequencing analysis shows that CD19, primarily considered as a B cell-specific surface antigen, is expressed in human brain mural cells that are critical for blood-brain-barrier integrity, suggesting that this cell population may contribute to the neurotoxicity of CD19-directed immunotherapy including CAR-T.

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    • Neat! Single-cell RNA sequencing shows #CD19 expression in brain mural cells that could explain #neurotoxicity of #immunotherapy by #CART cells or #BiTE antibodies, article in @CellPressNews by @Satpathology @IAmDrDex @HowardYChang @carlhjune! https://t.co/NStwgrqbUH https://t.co/Vv2OOwSdq5