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Mashup Score: 0Structure of the membrane-bound formate hydrogenlyase complex from Escherichia coli - Nature Communications - 1 year(s) ago
New cryo-EM structures of the formate hydrogenlyase complex from the model bacterium E. coli clarify how electrons and protons move through the complex and are combined to make H2 gas. The complex shows important similarities and differences to related bioenergetic complexes across the tree of life.
Source: NatureCategories: General Medicine News, Latest HeadlinesTweet
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Mashup Score: 5Structural basis for safe and efficient energy conversion in a respiratory supercomplex - Nature Communications - 2 year(s) ago
Aerobic energy metabolism is driven by proton-pumping respiratory supercomplexes. The study reports the structural basis for energy conversion in such supercomplex. It may aid metabolic engineering and drug design against diphtheria and tuberculosis.
Source: NatureCategories: General Medicine News, Latest HeadlinesTweet-
Researchers from @CIBSS_UniFR report the Cryo-EM structure of the cytochrome bcc-aa3 (III2-IV2) supercomplex from the actinobacterium Corynebacterium glutamicum. @W_C_K_ #bioenergetics #cryo-EM #Actinobacteria #supercomplex https://t.co/NeJ8lXtZ34 https://t.co/c3fDS1cLHU
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Mashup Score: 7
Ca2+ flow from the ER to mitochondria promotes ATP production through oxidative phosphorylation. Gutiérrez et al . investigated the role of calnexin, an ER chaperone that interacts with SERCA, the ATPase that pumps Ca2+ into the ER, in mitochondrial bioenergetics. The authors found that calnexin maintained SERCA in a redox state that was optimal for activity. Mitochondria were closer to the ER in…
Source: Science SignalingCategories: Future of Medicine, Latest HeadlinesTweet-
Researchers discover that the protein #calnexin fine-tunes cellular #bioenergetics by controlling the flow of calcium ions from a subcellular structure called the endoplasmic reticulum to #mitochondria. @scisignal https://t.co/L3KDCTlFH3 Credit: Keith R. Porter/Science Source https://t.co/oQrrjJkUF9
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Mashup Score: 24
Ca2+ flow from the ER to mitochondria promotes ATP production through oxidative phosphorylation. Gutiérrez et al . investigated the role of calnexin, an ER chaperone that interacts with SERCA, the ATPase that pumps Ca2+ into the ER, in mitochondrial bioenergetics. The authors found that calnexin maintained SERCA in a redox state that was optimal for activity. Mitochondria were closer to the ER in…
Source: Science SignalingCategories: Future of Medicine, Latest HeadlinesTweet-
Researchers discover that the protein #calnexin fine-tunes cellular #bioenergetics by controlling the flow of calcium ions from a subcellular structure called the endoplasmic reticulum to #mitochondria. @SciSignal https://t.co/SBLVWI4Z6Z Credit: Keith R. Porter/Science Source https://t.co/j33o0kF0Ey
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Mashup Score: 155Mitochondrial pyruvate and fatty acid flux modulate MICU1-dependent control of MCU activity - 4 year(s) ago
Ca2+ entering mitochondria through the mitochondrial Ca2+ uniporter (MCU) normally promotes the generation of ATP through the TCA cycle. Nemani et al. found that nutrient stress initiated a transcriptional program that restricted Ca2+ influx into mitochondria through the MCU to prevent changes in mitochondrial dynamics and bioenergetics. Pharmacological or genetic disruptions in glycolysis or…
Source: Science SignalingCategories: Future of Medicine, Latest HeadlinesTweet-
How do cells deal with nutrient stress? In the new issue of @SciSignal, scientists detail a genetic rheostat that limits #bioenergetics crises by preventing mitochondria from becoming overloaded with calcium ions. #Metabolism https://t.co/jX23ldV2xM Credit: Nemani et al. https://t.co/mpDeQCt9yJ
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Mashup Score: 30Mitochondrial pyruvate and fatty acid flux modulate MICU1-dependent control of MCU activity - 4 year(s) ago
Ca2+ entering mitochondria through the mitochondrial Ca2+ uniporter (MCU) normally promotes the generation of ATP through the TCA cycle. Nemani et al. found that nutrient stress initiated a transcriptional program that restricted Ca2+ influx into mitochondria through the MCU to prevent changes in mitochondrial dynamics and bioenergetics. Pharmacological or genetic disruptions in glycolysis or…
Source: Science SignalingCategories: Future of Medicine, Latest HeadlinesTweet-
How do cells deal with nutrient stress? In the new issue of @SciSignal, scientists detail a genetic rheostat that limits #bioenergetics crises by preventing mitochondria from becoming overloaded with calcium ions. #Metabolism https://t.co/jX23ldV2xM Credit: Nemani et al. https://t.co/mN2Q9VKzqZ
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Scientists from @MPIb, @RalfSteinhilper @_Murphy_Lab report cryoEM structures of the formate-hydrogen lyase complex & clarify how electrons & protons move through the complex & are combined to make H2 gas. #CryoEM #hydrogenase #bioenergetics https://t.co/PH7jLSXXHy https://t.co/M9CTcHAQCO