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    DEFINE_ME - 3 year(s) ago

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    • Association of Baclofen With Falls and Fractures in Patients With CKD https://t.co/gGkKyCtBK2 (FREE) @FloryTsobo @matthewweir @ICESOntario @LouiseMoist1 @AmitXGarg #CKD #baclofen https://t.co/Moig9GyU37

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    Baclofen is a popular muscle relaxant that is eliminated primarily unchanged in the urine.1 We recently reported a higher risk of encephalopathy in a cohort of 15,942 older adults with chronic kidney disease (CKD) who started baclofen at≥20 versus<20mg/d; a higher risk was also observed in all baclofen users versus nonusers.2 In another study of patients receiving dialysis, 1 in 14 were...

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    • Association of Baclofen With Falls and Fractures in Patients With CKD https://t.co/i5FzyXQHaL (FREE) @FloryTsobo @matthewweir @ICESOntario @LouiseMoist1 @AmitXGarg #CKD #baclofen https://t.co/97XoldgBHJ

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    Two years ago, French regulators overruled one of their own expert committees to approve a controversial drug for combating alcohol use disorder.

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    • A pill to fight alcoholism causes an uproar in France over a regulator’s view of a clinical trial.. https://t.co/wFBEGb5VLU #pharma #baclofen #alcoholism #transparency #France #clinicaltrials

  • Mashup Score: 1

    Baclofen, a commonly prescribed muscle relaxant, is primarily excreted via the kidneys; toxicity is a potentially serious adverse outcome in patients with decreased kidney function. We describe a patient with end-stage kidney disease receiving hemodialysis who developed neurotoxicity and hemodynamic instability after receiving baclofen for muscle spasms. In this case, prompt recognition of…

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    • ICYMI Teaching Case from Feb 2018: Baclofen Toxicity in Kidney Disease https://t.co/LmtBAGIrPl @NirajRKothari @John_K_Roberts @Nephro_Sparks #baclofen https://t.co/N5fTPADfuM