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    The addition of the monoclonal antibody atezolizumab to the tyrosine kinase inhibitor cabozantinib failed to improve progression-free survival and overall survival vs cabozantinib alone in patients with advanced renal cell carcinoma (previously treated with an immune checkpoint inhibitor) in the phase III CONTACT-03 trial. 1 The results of this study were published in The Lancet to coincide with the presentation at the 2023 ASCO Annual Meeting. 2 According to central review, median progression-free

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    • More on Renal Cell Carcinoma From ASCO 2023: Focus on Atezolizumab Plus Cabozantinib vs Cabozantinib Alone https://t.co/Dr4uputNa1 #RCC #kcsm #kidneycancer #oncology #ASCO23

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    Ilana Graetz, PhD, Emory University, Atlanta, GA, discusses a study aimed to pilot test a mobile health intervention, the CONnected CUstomized Treatment Platform, in women with hormone receptor-positive, metastatic breast cancer. The intervention included a smartbox for real-time adherence monitoring, text message reminders for missed or extra doses, and referrals to the oncology provider or a financial navigation program as needed. Out of 29 participants, 72.4% used the smartbox, and the adherence rate for palbociclib was 95.8% ± 7.6%. Only a few participants had adherence barriers at baseline. There were no significant changes in self-reported adherence, symptom burden, or quality of life over three months. The usability score of the CONnected CUstomized Treatment Platform was 61.9 ± 14.2. The study concluded that the intervention was feasible and resulted in high adherence, but further improvements in usability should be explored. This interview took place at the American Society of

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    • 🎥@ilana_graetz of @EmoryUniversity presents a mobile health intervention for patients with metastatic #BreastCancer, showing high adherence rates with room for usability improvements: ➡️https://t.co/ACc6uCQvzP #BCSM #ASCO23

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    W. Choi1, Y. Jia1, J. Kwak2, A. P. Dicker1, N. L. Simone1, E. Storozynsky3, V. Jain1, and Y. Vinogradskiy1; 1Department of Radiation Oncology, Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, PA, 2University of Colorado School of Medicine, Aurora, CO, 3Department of Cardiology, Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia,…

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    • #ASCO23: Dr. Wookjin Choi discussing a radiomics model to predict clinical cardiac assessment of standard-of-care FDG-based PET/CT scans in #LungCancer during a quick pitch oral session at 5:30 p.m. PT: https://t.co/p0nkyNGIvK https://t.co/lmorRrhawj

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    Michael Gnant, MD, FACS, FEBS, Medical University of Vienna, Vienna, Austria, gives an overview of current CDK4/6 inhibitors in early breast cancer. Recent trials such as the Phase II NATALEE trial (NCT03701334) of ribociclib plus endocrine therapy, the Phase II monarchE trial (NCT03155997) of abemaciclib and the Phase III Penelope-B trial (NCT01864746) of palbociclib have all demonstrated promising results. Prof. Gnant additionally talks on the PHERGain trial (NCT03161353) of dual HER2 blockade in early breast cancer. This interview took place at the American Society of Clinical Oncology (ASCO) 2023 Annual Congress in Chicago, IL. These works are owned by Magdalen Medical Publishing (MMP) and are protected by copyright laws and treaties around the world. All rights are reserved.

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    • 📣October is Breast Cancer Awareness Month 📅 Check out this interview from #ASCO23, where @MichaelGnant discusses the role of #CDK4/6 inhibitors in early #breastcancer: ➡️https://t.co/c1RmY8FsgV🎥 #BCSM

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    In this podcast we’ll hear from experts in GU cancer on some of the most exciting clinical trial data in…

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    • Did you know that September is Urological Cancer Awareness Month? 🤔 Listen to our podcast on #bladdercancer highlights from #ASCO23, including results from the THOR, NORSE, and RAGNAR trials! Give it a listen 👉 https://t.co/u7BaS4bwEo #Oncology #GUsm #PCsm #uroonc https://t.co/sy8RcPqdwM

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    Anusha Chidharla, MBBS, University of Kansas Medical Center, Kansas City, MO, compares the real-world data of belzutifan in VHL-associated tumors versus clinical trial data. The objective response rate (ORR) for associated renal cell cancer was 23%, lower than the clinical trial’s 49%, likely due to shorter follow-up duration (8 months vs. 21 months) and less frequent scans. Safety findings were similar, with common side effects being anemia and fatigue (65-70%). Belzutifan dose was decreased in 30% of our patients (vs. 15% in the clinical trial) due to poorer performance status (ECOG 1-2 vs. ECOG 0). These results highlight the importance of longer follow-up and more frequent scans to capture treatment responses accurately in the real-world setting. This interview took place at the American Society of Clinical Oncology (ASCO) 2023 Annual Congress in Chicago, IL. These works are owned by Magdalen Medical Publishing (MMP) and are protected by copyright laws and treaties around the world

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    • 🎥Anusha Chidharla, MBBS, of @KUMedCenter presents real-world data on belzutifan in VHL-associated tumors, highlighting the need for longer follow-up and more scans for accurate treatment assessment: ➡️https://t.co/krZX6On1k4 #ASCO23 #UroOnc #UroSoMe

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    Anna Minchom, MB BCh, MRCP, MD, discusses the need to develop an amivantamab administration method that decreases the likelihood of infusion-related reactions in patients with solid tumors, revealed the RP2D of subcutaneous amivantamab that was determined in the PALOMA trial, and emphasized potential future directions with this agent.

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    • Anna Minchom, MB BCh, MRCP, MD, discusses the need to develop an amivantamab administration method decreasing the likelihood of infusion-related reactions in patients with solid tumors. @Anna_Minchom @ICR_London #ASCO23 #oncology https://t.co/kL5zEQNGMg

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    Anna Minchom, MB BCh, MRCP, MD, discusses the need to develop an amivantamab administration method that decreases the likelihood of infusion-related reactions in patients with solid tumors, revealed the RP2D of subcutaneous amivantamab that was determined in the PALOMA trial, and emphasized potential future directions with this agent.

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    • Subcutaneous administration of amivantamab led to low rates of infusion-related reactions and a safety profile consistent with that historically associated with the IV administration of the drug in solid tumors. @Anna_Minchom @ICR_London #ASCO23 #oncology https://t.co/kL5zEQNGMg https://t.co/B1KH8Fj0HX

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    Pedro Barata, MD, University Hospitals Seidman Cancer Center, Cleveland, OH, provides important updates in genitourinary cancer at the American Society of Clinical Oncology (ASCO) 2023 Annual Congress, including findings from the PEACE-1 trial (NCT01957436), as well as updates in PARP inhibitors with radioligands in prostate cancer. Dr Barata additionally comments on trials assessing salvage chemotherapy in renal cell carcinoma (RCC) and targeting EGFR in bladder cancer. This interview took place at the ASCO 2023 Annual Congress in Chicago, IL. These works are owned by Magdalen Medical Publishing (MMP) and are protected by copyright laws and treaties around the world. All rights are reserved.

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    • Did you know that September is Urological Cancer Awareness Month? 🤔 Check out this interview from our #GUCancer channel with @PBarataMD, where he discusses highlights in #genitourinarycancer at #ASCO23 👉 https://t.co/QELNE442c5 #GUsm #PCsm #uroonc https://t.co/ZMRsMXHdJd

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    Yutaka Yamamoto, MD PhD, Kumamoto University Hospital, Kumamoto, Japan, comments on the current state of targeted therapies for HER2+ and HR+ breast cancer. Although clinically applicable results for immune checkpoint inhibitors have not yet been obtained for these types of breast cancer, antibody-drug conjugates such as trastuzumab deruxtecan (T-DXd) are being rapidly developed. This interview took place during the American Society of Clinical Oncology (ASCO) 2023 Annual Meeting in Chicago, IL. These works are owned by Magdalen Medical Publishing (MMP) and are protected by copyright laws and treaties around the world. All rights are reserved

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    • 🎥Yutaka Yamamoto, MD PhD, of @IRCMS_KU shares insights on the evolving landscape of targeted therapies for HER2+ and HR+ #BreastCancer. While ICI's are pending, ADCs like T-DXd show promise: ➡️https://t.co/pmVJH0YFbp⬅️ #ASCO23 #BCSM #ImmunOnc