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Mashup Score: 6Ancient skeleton with RA may suggest ‘we’ve been dealing with these diseases forever’ - 13 day(s) ago
Archaeologists in Egypt recently discovered evidence of an ancient case of rheumatoid arthritis, potentially filling in the timeline of humanity’s relationship with autoimmune disease. The skeleton was excavated in 2018 from an ancient cemetery in what is now Aswan, in southern Egypt, and determined to be that of a woman aged 25 to 30 years who lived between 1750 BCE and 1550 BCE.
Source: www.healio.comCategories: General Medicine News, RheumatologyTweet
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Mashup Score: 2Severe joint pain more prevalent in Black, Hispanic, Indigenous patients vs white patients - 17 day(s) ago
Among adults with arthritis, severe joint pain is significantly more prevalent in Black, Hispanic, American Indian and Alaska Native patients vs. white patients, according to data published in Arthritis Care & Research.In addition, the researchers found that fewer than 60% of any of these groups receive counseling on physical activity.
Source: www.healio.comCategories: General Medicine News, RheumatologyTweet
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Mashup Score: 7Podcast: Debunking Arthritis Myths | Arthritis Foundation - 1 month(s) ago
Get the real story on arthritis. In this episode, a patient and rheumatologist debunk harmful myths and shed light on the truth, offering clear information for those living with the disease.
Source: www.arthritis.orgCategories: General Medicine News, RheumatologyTweet
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Mashup Score: 13
A University of Colorado Department of Medicine faculty member says she and her colleagues have identified the means in which bacteria in the digestive system can break down tryptophan in the diet into …
Source: medicalxpress.comCategories: General Medicine News, General HCPsTweet
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Mashup Score: 11Immune response to post-translationally modified proteins in rheumatoid arthritis: what makes it special? - 2 month(s) ago
Rheumatoid arthritis (RA) exhibits common characteristics with numerous other autoimmune diseases, including the presence of susceptibility genes and the presence of disease-specific autoantibodies. Anti-citrullinated protein antibodies (ACPA) are the hallmarking autoantibodies in RA and the anti-citrullinated protein immune response has been implicated in disease pathogenesis. Insight into the immunological pathways leading to anti-citrullinated protein immunity will not only aid understanding of RA pathogenesis, but may also contribute to elucidation of similar mechanisms in other autoantibody-positive autoimmune diseases. Similarly, lessons learnt in other human autoimmune diseases might be relevant to understand potential drivers of RA. In this review, we will summarise several novel insights into the biology of the anti-citrullinated protein response and their clinical associations that have been obtained in recent years. These insights include the identification of glycans in the
Source: ard.bmj.comCategories: General Medicine News, RheumatologyTweet
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Mashup Score: 33Comorbidity clusters in patients with rheumatoid arthritis identify a patient phenotype with a favourable prognosis - 2 month(s) ago
Objectives We aimed to cluster patients with rheumatoid arthritis (RA) based on comorbidities and then examine the association between these clusters and RA disease activity and mortality. Methods In this population-based study, residents of an eight-county region with prevalent RA on 1 January 2015 were identified. Patients were followed for vital status until death, last contact or 31 December 2021. Diagnostic codes for 5 years before the prevalence date were used to define 55 comorbidities. Latent class analysis was used to cluster patients based on comorbidity patterns. Standardised mortality ratios were used to assess mortality. Results A total of 1643 patients with prevalent RA (72% female; 94% white; median age 64 years, median RA duration 7 years) were studied. Four clusters were identified. Cluster 1 (n=686) included patients with few comorbidities, and cluster 4 (n=134) included older patients with 10 or more comorbidities. Cluster 2 (n=200) included patients with five or mor
Source: ard.bmj.comCategories: General Medicine News, RheumatologyTweet
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Mashup Score: 25New PET tracer detects inflammatory arthritis before symptoms appear - 2 month(s) ago
A novel PET imaging technique can noninvasively detect active inflammation in the body before clinical symptoms arise, according to research published in the February issue of The Journal of Nuclear Medicine. …
Source: medicalxpress.comCategories: General Medicine News, General NewsTweet
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Mashup Score: 0
Patients with inflammatory arthritis demonstrated significantly increased odds of depression and anxiety health care encounters and use of anxiolytics and antidepressants.
Source: www.hcplive.comCategories: General Medicine News, General HCPsTweet
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Mashup Score: 0
Patients with inflammatory arthritis demonstrated significantly increased odds of depression and anxiety health care encounters and use of anxiolytics and antidepressants.
Source: www.hcplive.comCategories: General Medicine News, General HCPsTweet
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Mashup Score: 17Diurnal production of cortisol and prediction of treatment response in rheumatoid arthritis: a 6-month, real-life prospective cohort study - 3 month(s) ago
Objectives A reduced adrenal reserve-associated cortisol production relative to the enhanced needs of chronic inflammation ( disproportion principle ) has been observed in rheumatoid arthritis (RA). We examined the possible clinical value of diurnal cortisol measurements in active RA on treatment response prediction. Methods Diurnal cortisol production (measured at: 08–12:00/18:00–22:00) was assessed by electrochemiluminescence immunoassay in 28 consecutive patients with moderately/highly active RA, as well as 3 and 6 months after treatment initiation or/escalation. Twenty-eight COVID-19 patients and 28 age-matched healthy individuals (HC) served as controls. Results Saliva diurnal cortisol production in patients with RA was similar to that of HC, despite 12-fold higher serum C reactive protein (CRP) levels, and lower than COVID-19 patients (area under the curve: RA: 87.0±37.6 vs COVID-19: 146.7±14.3, p<0.001), having similarly high CRP. Moreover, a disturbed circadian cortisol rhythm
Source: rmdopen.bmj.comCategories: General Medicine News, RheumatologyTweet
What can we learn from an ancient skeleton 🦴 with signs of rheumatoid #arthritis excavated from the sands of Egypt? 🔍It could be one more clue "that we’ve been dealing with these diseases forever," @AdamJBrownMD says Find out more in this Q&A 👇 https://t.co/uoqXRh10x8