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    Therapy resistance to second-generation androgen receptor (AR) antagonists, such as enzalutamide, is common in patients with advanced prostate cancer (PCa). To understand the metabolic alterations involved in enzalutamide resistance, we performed metabolomic, transcriptomic, and cistromic analyses of enzalutamide-sensitive and -resistant PCa cells, xenografts, patient-derived organoids,…

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    • From @gr8straj , @EliotBlatt & co-workers: Identification of the central role of #antioxidant programs in enzalutamide-resistant #ProstateCancer 🔬https://t.co/5i0Bv2FXmv

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    The human nucleus is metabolically active, according to the findings of a new study in Molecular Systems Biology by researchers at the CRG in Barcelona and CeMM/Medical University of Vienna, In a state of crisis, such as widespread DNA damage, the nucleus protects itself by appropriates mitochondrial machinery to carry out urgent repairs that threaten the genome’s integrity The findings…

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    • In crisis, the nucleus calls #antioxidant #enzymes to the rescue; The #nucleus being metabolically active is a profound paradigm shift with implications for #cancerresearch @CRGenomica https://t.co/lM2rtmzQ87

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    Wolters Kluwer Health - 11 month(s) ago

    JavaScript Error JavaScript has been disabled on your browser. You must enable it to continue. Here’s how to enable JavaScript in the following browsers: Internet Explorer From the Tools menu, select Options Click the Content tab Select Enable JavaScript Firefox From the Tools…

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    • Composite #dietary #antioxidant intake and #osteoporosis likelihood in premenopausal and postmenopausal women: a population-based study in the U.S. https://t.co/VWN9yDXRVU @MenopauseOrg @LippincottMed #menopause

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    Wolters Kluwer Health - 1 year(s) ago

    JavaScript Error JavaScript has been disabled on your browser. You must enable it to continue. Here’s how to enable JavaScript in the following browsers: Internet Explorer From the Tools menu, select Options Click the Content tab Select Enable JavaScript Firefox From the Tools…

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    • Composite #dietary #antioxidant intake and #osteoporosis likelihood in #premenopausal and #postmenopausal women: a population-based study in the United States https://t.co/ClRbJdOMTz @MenopauseOrg @LippincottMed

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    Sulfur Rich Foods: Why You Should Eat Them You’ve probably never sought out eating sulfur rich foods, unless of course, you are on the Wahl’s Diet/Protocol. however, a little known fact is that sulfur is a mineral that is critical to the human body. It helps build amino acids and vitamins and is critical to healthy development of skin, bones, nerve cells and other tissues….

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    • Sulfur-rich foods support #glutathione, an intracellular #antioxidant that helps cells detoxify.https://t.co/5MLpx30ybu https://t.co/JlVdzGd0SD