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Mashup Score: 2Transient CD4+ T cell depletion during suppressive ART reduces the HIV reservoir in humanized mice - 4 month(s) ago
Author summary Current long-term antiretroviral therapy does not eradicate cells latently infected with HIV. Latently HIV-infected cells are essentially indistinguishable from uninfected cells and cannot be easily targeted by currently available strategies. CD4+ T cells represent the most well-characterized and largest HIV reservoir. Anti-CD4 antibody mediated CD4+ T cells depletion has been proved to be reversible and well-tolerated in humans. In this study, we evaluated the effect of transient depletion of human CD4+ T cells with an anti-CD4 antibody on the size of the HIV reservoir in HIV-infected ART-suppressed humanized mice. CD4+ T cells in the peripheral blood and tissues of humanized mice were effectively depleted. Importantly, the size of the HIV reservoir was significantly decreased in anti-CD4 antibody treated animals following CD4+ T cell recovery compared with untreated controls.
Source: journals.plos.orgCategories: General Medicine News, Infectious DiseaseTweet
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Mashup Score: 2mAb therapy controls CNSāresident lyssavirus infection via a CD4 T cellādependent mechanism - 6 month(s) ago
Rabies is a fatal viral disease of humans, with uniform mortality once central nervous system (CNS) invasion occurs and symptoms appear. This study demonstrates that a single-dose monoclonal (mAb) th…
Source: www.embopress.orgCategories: Infectious Disease, Latest HeadlinesTweet-
This study out of @USUhealthsci shows that a single dose of F11, an anti-lyssavirus human monoclonal #antibody, limited viral load in the š§ brain and reversed disease signs following #infection with a lethal dose of #lyssavirus! @EmboMolMed | https://t.co/xdo3th54zX https://t.co/f6rT6ojs3J
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Mashup Score: 0Danaher to buy antibody supplier Abcam for $5.7B - 8 month(s) ago
The acquisition gives Danaher an entry into the protein consumables market, Stifel analysts said.
Source: www.medtechdive.comCategories: Future of Medicine, Latest HeadlinesTweet-
.@DanaherCorp to buy #antibody supplier @abcam for $5.7B - acquisition gives Danaher an entry into the protein consumables market, Stifel analysts said. | #MnA https://t.co/mRKcmUx0xy
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Mashup Score: 0
An abstract is unavailable.
Source: journals.lww.comCategories: Hem/Onc News and Journals, Latest HeadlinesTweet-
Adding the novel, engineered #antibody domvanalimab to #immunotherapy improves overall response rates and progression-free survival compared to treatment with immunotherapy alone for patients with Stage IV non-small cell lung cancer: https://t.co/kJsSUPEZE7 #CancerResearch https://t.co/QORYkH58XX
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Mashup Score: 2Engineered CAR T Cells Locally Deliver Blocker of CD47 Pathway | ASH Clinical News | American Society of Hematology - 12 month(s) ago
Skip Nav Destination April 11, 2023 Ruth Jessen Hickman, MD, is a freelance medical and science writer based in Bloomington, Indiana. Chimeric antigen receptor (CAR) T-cell therapy has demonstrated high response rates in patients…
Source: ashpublications.orgCategories: Hem/Oncs, Latest HeadlinesTweet-
To combat relapse rates associated with #CAR #Tcell therapy, researchers have engineered "Orexiā CAR T cells to locally secrete CV1, a high-affinity CD47 blocker, at the tumor site, combining treatment with an orthogonally targeted #monoclonal #antibody https://t.co/FCWGIL8Wf6
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Mashup Score: 0Antibody Correlates of Protection for COVID-19 Convalescent Plasma Associated with Reduced Outpatient Hospitalizations - 12 month(s) ago
SARS-CoV-2 antibody levels associated with reduced hospitalization risk remain undefined. Our outpatient COVID-19 convalescent plasma (CCP), placebo-controlled trial observed SARS-CoV-2 antibody levels decreasing 22-fold from matched donor units into post-transfusion seronegative recipients. Unvaccinated recipients were jointly stratified by a) early or late transfusion (ā¤ 5 or >5 days from…
Source: medRxivCategories: Latest Headlines, PulmonologyTweet-
#Antibody Correlates of #Protection for #COVID19 Convalescent #Plasma Associated with Reduced #Outpatient #Hospitalizations https://t.co/Tv9YNOKBoL https://t.co/6F6E6XYqkB
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Mashup Score: 0
Responses in 37% of patients previously treated with anti-PD-1/L1 agents, platinum chemotherapy
Source: www.medpagetoday.comCategories: Latest Headlines, Oncologists2Tweet-
A preliminary clinical trial showed that more than a third of patients with previously treated head and neck #cancer responded to a novel bispecific #antibody. #AACR23 #AACR2023 @AACR https://t.co/KDb5qgGlMf
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Mashup Score: 0
A study of Navy sailors and Marines from the United States found that only 7.7% of participants had neutralizing antibodies for the Omicron variant 8 months after vaccination.
Source: AJMCCategories: General Medicine Journals and Societies, Latest HeadlinesTweet-
Antibodies against Omicron BA.1 saw a reduction as time went on post #COVID-19 vaccination, and researchers found that #antibody responses to BA.2 and BA.5 were also reduced, according to a study published in @JIDJournal. https://t.co/kNhQaV52z5 https://t.co/8tClEjKiIf
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Mashup Score: 0
The efficacy of SARS-CoV-2 vaccines is higher for preventing severe infection and death than for preventing milder infection. Vaccine efficacy wanes over time but can be enhanced by a booster. Higher antibody titres are associated with higher estimates of efficacy but precise predictions are difficult due to large unexplained heterogeneity. These findings provide an important knowledge base for…
Source: The Lancet MicrobeCategories: Infectious Disease, Latest HeadlinesTweet-
The efficacy of #SARSCoV2 vaccines š in preventing severe #COVID19 illness and death is uncertain. That's why researchers assessed š the doseāresponse relationship between the #antibody concentrations and efficacy! Curious for more? @LancetMicrobe | š https://t.co/Z3cSqh5GMj https://t.co/lOw7Jx485e
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Mashup Score: 3For optimal antibody effectiveness, sometimes less is more - 1 year(s) ago
Modulating receptor-binding affinity influences antibody effectiveness.
Source: www.nature.comCategories: Hem/Oncs, Latest HeadlinesTweet-
Optimal #antibody effectiveness depends on the level of affinity binding. For blocking antibodies, a high affinity may be most effective. However, for agonist antibodies, recent results suggest that intermediate affinity works best, for #immunotherapy. https://t.co/gvmj87o5ne https://t.co/4pyCY4WT0J
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Dr. Victor Garcia's team at @UABNews studied #antibody mediated transient CD4+ T cell depletion as a strategy to reduce the latent HIV reservoir! Depletion during suppressive antiretroviral therapy š was found to reduce HIV reservoir! @PLOSPathogens | https://t.co/hfaRbr1BPF https://t.co/5SF3yOWBvG