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Mashup Score: 0
AbstractAims. Angiotensin-converting enzyme 2 (ACE2) is a critical component of the compensatory renin–angiotensin system that is down-regulated during the deve
Source: OUP AcademicCategories: Cardiology News and Journals, Latest HeadlinesTweet
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Mashup Score: 1
Background: The ADRB3 (β3-adrenergic receptors), which is predominantly expressed in brown adipose tissue (BAT), can activate BAT and improve metabolic health. Previous studies indicate that the endo
Source: Circulation ResearchCategories: Cardiology News and Journals, Latest HeadlinesTweet-
Lin & colleagues demonstrate that #ADRB3 activation in brown #adipocytes protect against #AngII induced cardiac remodeling via suppressing #iNOS containing #exosomes. Learn more at https://t.co/GmLdrM6mts https://t.co/RsfXTXivUW
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Mashup Score: 0
Background: Perivascular fibrosis, characterized by increased amount of connective tissue around vessels, is a hallmark for vascular disease. Ang II (angiotensin II) contributes to vascular disease a
Source: Circulation ResearchCategories: Cardiology News and Journals, Latest HeadlinesTweet-
Zhuang & colleagues discovered that #Tcell specific removal of #Klf10 exacerbated perivascular #fibrosis & multi-organ dysfunction in an #AngII #hypertension mouse model through #IL9. Learn more at https://t.co/6A4XM05r9I @bwhcvls @BrighamResearch @preetiaahir https://t.co/gfi5jVsjGd
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Mashup Score: 2
12/15-LO (12/15-lipoxygenase), encoded by Alox15 gene, metabolizes arachidonic acid to 12(S)-HETE (12-hydroxyeicosatetraenoic acid). Macrophages are the major source of 12/15-LO among immune cells, a
Source: HypertensionCategories: Cardiology News and Journals, Latest HeadlinesTweet-
Our study provides a new mechanism for sensitizing vasoconstriction, wherein the #Macrophage 12/15-lipoxygenase pathway enhances #AngII effects. Inhibition of this pathway decreases #BloodPressure and may reveal a new approach to treating #Hypertension. https://t.co/tYdKRkPbQy https://t.co/ywUN9edBfd
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Mashup Score: 46β-Hydroxytestosterone Promotes Angiotensin II-Induced Hypertension via Enhanced Cytosolic Phospholipase A2α Activity - 3 year(s) ago
This study was conducted to test the hypothesis that the CYP1B1 (cytochrome P450 1B1)-testosterone metabolite 6β-hydroxytestosterone contributes to angiotensin II-induced hypertension by promoting ac
Source: HypertensionCategories: Cardiology News and Journals, Latest HeadlinesTweet-
#Testosterone metabolites may contribute to #AngII-mediated #Hypertension #HeartDisease and #KidneyDisease via PLA activation. https://t.co/KNwRvHvXS5 https://t.co/CSE1LKjWta
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Mashup Score: 5
Rationale: The renin-angiotensin system is a complex regulatory network that maintains normal physiological functions. The role of the renin-angiotensin system in sepsis-induced myocardial dysfunctio
Source: Circulation ResearchCategories: Cardiology News and Journals, Latest HeadlinesTweet-
Rong et al identified a liver-heart axis in which deficiency of #hepatocyte-derived #angiotensinogen attenuates #sepsis-induced #MyocardialDysfunction via both #AngII-dependent and AngII-independent pathways. https://t.co/xacNZf5qgl @honglu227 @alan_daugherty https://t.co/20vgHXaaof
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Mashup Score: 6Blocking FcγRIIB in Smooth Muscle Cells Reduces Hypertension - 3 year(s) ago
Rationale: Hypertension is a common chronic disease, and its prevalence is increasing. Immunoglobulins play crucial roles in adaptive immune response and have been implicated in the pathogenesis of h
Source: Circulation ResearchCategories: Cardiology News and Journals, Latest HeadlinesTweet-
Song & colleagues found that smooth muscle-specific gene depletion or treatment with antibody against #FcγRIIB alleviates #AngII-induced vascular remodeling and #hypertension in mice. Learn more how FcγRIIB acts as an inhibitory IgG receptor https://t.co/GVYBNFUAJ1 https://t.co/76jD1bqmc1
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Mashup Score: 1Loss of Soluble (Pro)renin Receptor Attenuates Angiotensin-II Induced Hypertension and Renal Injury - 3 year(s) ago
Rationale: Cleavage of the extracellular domain of the PRR ([pro]renin receptor) yields a soluble fragment (sPRR). Although changes in plasma sPRR levels have been reported in hypertension, the causa
Source: Circulation ResearchCategories: Cardiology News and Journals, Latest HeadlinesTweet-
In this issue @niruramkumar and colleagues found that loss of #sPRR reduces #BP at baseline and #AngII induced #hypertension and #kidney injury independent of the #RAAS https://t.co/R327YxRI2z https://t.co/wQMzHfIGE9
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Mashup Score: 0Targeting mitochondrial fission as a potential therapeutic for abdominal aortic aneurysm - 4 year(s) ago
AbstractAims. Angiotensin II (AngII) is a potential contributor to the development of abdominal aortic aneurysm (AAA). In aortic vascular smooth muscle cells (
Source: OUP AcademicCategories: Cardiology News and Journals, Latest HeadlinesTweet-
#ANGII activation of Drp1 drives mitochondrial fission & #inflammatory activation of vascular smooth muscle in abdominal #aortic #aneurysms (AAA). Is Drp1 a potential therapeutic target for AAA? https://t.co/EqxGveOdAJ @CVR_TomaszGuzik #CardioTwitter #CardiovascularResearch https://t.co/ygU2Dl8J3s
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Mashup Score: 0
Rationale: Kidney homeostasis is critically determined by the coordinated activity of the renin-angiotensin system (RAS), including the balanced synthesis of its main effector peptides Ang (angiote…
Source: www.ahajournals.orgCategories: Cardiology News and Journals, Latest HeadlinesTweet-
#Neprilysin regulates Ang-(1-7) and confers protection in the healthy #kidney but in #ChronicKidneyDisease Ang-(1-7) is decreased and #AngII levels increased https://t.co/hEKwwS8mSk @MedUni_Wien https://t.co/SJI2sX0GjQ
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Short-circuiting #BloodPressure regulation🔌⚡️ #ANGII upregulation of neural Nedd4-2 promotes #ACE2 ubiquitination to decrease PVN sympathetic inhibition & drive #hypertension https://t.co/sYErpFMeJm @CVR_TomaszGuzik @DrMikeDrozd @glenpyle #CardiovascularResearch #CardioTwitter https://t.co/I9O0s9dMFS