-
Mashup Score: 1A Holy Grail — The Prediction of Protein Structure | NEJM - 6 month(s) ago
Clinical Implications of Basic Research from The New England Journal of Medicine — A Holy Grail — The Prediction of Protein Structure
Source: www.nejm.orgCategories: General Medicine Journals and Societies, Latest HeadlinesTweet
-
Mashup Score: 25The midnolin-proteasome pathway catches proteins for ubiquitination-independent degradation - 8 month(s) ago
Midnolin associates with the proteasome to promote degradation of nuclear proteins through a ubiquitination-independent mechanism.
Source: www.science.orgCategories: Expert Picks, Latest HeadlinesTweet-
Like cracking the nuclear pore complex, #AI #AlphaFold is helping to unravel biology, advancing life science, that was previously not possible. Here a new pathway for how cells break down proteins https://t.co/EKxVqajGIr https://t.co/H221PrPHFE https://t.co/UIvswYvVDl
-
-
Mashup Score: 7Characterization of a fold in TANGO1 evolved from SH3 domains for the export of bulky cargos - Nature Communications - 11 month(s) ago
The authors characterized a fold in the TANGO1 protein which evolved from SH3 domains for the export of bulky cargos such as collagen. They denote this fold as MOTH (MIA, Otoraplin, TALI/TANGO1 homology) domain.
Source: NatureCategories: General Medicine News, Latest HeadlinesTweet-
The @LabStoll and @droliverarnolds characterized a fold, MOTH (MIA, Otoraplin, TALI/TANGO1 2 homology) domain, in the TANGO1 protein which evolved from SH3 domains for the export of bulky cargos. @ruhrunibochum, #NMRchat #AlphaFold #ER #TANGO1 #metazoa https://t.co/7HeXgZVnOh https://t.co/9gbZujSjEQ
-
-
Mashup Score: 2
End-to-end AI drug discovery process predicts potential inhibitors for a protein implicated in liver cancer
Source: Chemistry WorldCategories: Healthcare Professionals, Latest HeadlinesTweet-
#AlphaFold works with other #AI tools to go from target to hit molecule in 30 days | #science #technology | @ChemistryWorld https://t.co/QVMOZXv0hj
-
-
Mashup Score: 154Programmable protein delivery with a bacterial contractile injection system - Nature - 1 year(s) ago
The tail fibre of an extracellular contractile injection system (eCIS) from Photorhabdus asymbiotica recognizes targets expressed on eukaryotic host cells, and can be reprogrammed to target specific organisms and cell types for delivery of novel protein payloads.
Source: NatureCategories: Expert Picks, Latest HeadlinesTweet-
Discovery of a "molecular syringe": new way to deliver functional proteins into human cells with very high efficiency that exploits #AlphaFold, #AI, and nature https://t.co/yvlBaXBCZO @heidiledford https://t.co/ImfwywvNJ0 @Nature @zhangf and colleagues
-
-
Mashup Score: 3TRAPPC2L-related disorder: first homozygous protein-truncating variant and further delineation of the phenotype - 1 year(s) ago
The TRAPP (TRAfficking Protein Particle) complexes are evolutionarily conserved tethering factors involved in the intracellular transport of vesicles for secretion and autophagy processes. Pathogenic variants in 8 genes (of 14) encoding TRAPP proteins are involved in ultra-rare human diseases, called TRAPPopathies. Seven of them are autosomal recessive neurodevelopmental disorders with…
Source: Journal of Medical GeneticsCategories: General Medicine Journals and Societies, Latest HeadlinesTweet-
#TRAPPC2L syndrome: a severe neurodevelopmental disorder and a rare congenital #MuscularDystrophy First homozygous protein-truncating variant & further phenotype delineation ➡️ https://t.co/hz70mVcLsq @mario_obj @FlorenceRicc Image #Alphafold via @uniprot https://t.co/Cns6SisfXo
-
-
Mashup Score: 5
In a first for drug discovery, a field where the lack of efficiency is a severe bottleneck, scientists at Insilico and the University of Toronto have applied DeepMind’s AlphaFold to an end-to-end AI-powered drug discovery platform (Pharma.AI) that includes a biocomputational engine (PandaOmics) and a generative chemistry platform (Chemistry42), to identify a new drug for a novel target, for the…
Categories: Future of Medicine, Latest HeadlinesTweet-
Scientists at @InSilicoMeds and @UofT have applied #AlphaFold to an end-to-end #AI powered #drugdiscovery engine and identified a new drug for a novel target with no crystal structure within 30 days. Learn more: https://t.co/80hyZtPr9M #cancer #livercancer #AI https://t.co/DMDdb8fpZg
-
-
Mashup Score: 6
In a first for drug discovery, a field where the lack of efficiency is a severe bottleneck, scientists at Insilico and the University of Toronto have applied DeepMind’s AlphaFold to an end-to-end AI-powered drug discovery platform (Pharma.AI) that includes a biocomputational engine (PandaOmics) and a generative chemistry platform (Chemistry42), to identify a new drug for a novel target, for the…
Categories: Future of Medicine, Latest HeadlinesTweet-
Scientists at @InSilicoMeds and @UofT have applied #AlphaFold to an end-to-end #AI powered #drugdiscovery engine and identified a new drug for a novel target with no crystal structure within 30 days. Learn more: https://t.co/80hyZtPr9M #cancer #livercancer #AI https://t.co/ul5ZLajw4U
-
-
Mashup Score: 1
Microbial molecules from soil, seawater and human bodies are among the planet’s least understood proteins.
Source: www.nature.comCategories: Healthcare Professionals, Latest HeadlinesTweet-
#AlphaFold’s new rival? Meta #AI predicts shape of 600 million proteins https://t.co/6XOaNcgnCd #HLTH2022 #Biotechnology
-
-
Mashup Score: 47Discovering faster matrix multiplication algorithms with reinforcement learning - Nature - 2 year(s) ago
A reinforcement learning approach based on AlphaZero is used to discover efficient and provably correct algorithms for matrix multiplication, finding faster algorithms for a variety of matrix sizes.
Source: NatureCategories: Expert Picks, Latest HeadlinesTweet-
You know #AlphaFold for predicting protein structure. Now there's #AlphaTensor with automated discovery of novel and efficient algorithms #AI @Nature https://t.co/iMcWj2UGsS https://t.co/HXxnWbQpUc https://t.co/sCCsMNOSfo
-
The 2023 @LaskerFDN Award for Basic Medical Research underscores the value of an AI system that predicts the three-dimensional structure of proteins from the one-dimensional sequence of their amino acids, known as #AlphaFold. @rbaltman explains: https://t.co/vg18uWyMCy