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    Katie Robinson is a medical writer based in New York. Patients undergoing a human leukocyte antigen (HLA)-matched allogeneic hematopoietic cell transplantation (alloHCT) with reduced-intensity conditioning who received a prophylaxis regimen of cyclophosphamide, tacrolimus, and mycophenolate mofetil had longer graft-versus-host disease (GVHD)-free, relapse-free survival than those who received standard prophylaxis of tacrolimus and methotrexate. These findings from a phase III study were published in the

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    • Patients undergoing an #alloHCT with reduced-intensity conditioning had longer GVHD-free and #relapse-free survival with a prophylaxis regimen of cyclophosphamide, tacrolimus, and mycophenolate mofetil than those treated with standard #prophylaxis. https://t.co/IE3sofWixi

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    Senjo H, Harada S, Kubota SI, et al. Calcineurin Inhibitor Inhibits Tolerance Induction by Suppressing Terminal Exhaustion of Donor T Cells After Allo-HCT. Blood. 2023; (doi:…

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    • Researchers may have uncovered why, despite routine prophylaxis, many #alloHCT recipients fail to attain long-term tolerance w/o development of chronic #GVHD, and it has to do with transitory-tex and terminally-tex T cells. Read more on Nucleus: https://t.co/fN4HklI9Je #CARTcells https://t.co/RMEhTBKflg

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    Fathi AT, Kim HT, Soiffer RJ, et al. Multi-Center Phase I Trial of Ivosidenib as Maintenance Treatment Following Allogeneic Hematopoietic Cell Transplantation for IDH1-Mutated Acute Myeloid Leukemia. Clinical Cancer Research. 2023; (doi: 10.1158/1078-0432.CCR-23-0182). A Phase I trial testing the isocitrate dehydrogenase 1 (IDH1) inhibitor ivosidenib as maintenance therapy in patients with…

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    • A Phase I trial testing isocitrate dehydrogenase 1 (IDH1) inhibitor ivosidenib as maintenance therapy in patients with IDH1-mutated #AML following #alloHCT found that it was safe and well-tolerated. Read more about the findings on Nucleus: https://t.co/q0mQpSStBU #Leusm https://t.co/R7O1kRG2n9

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    Dillon LW, Gui G, Page KM, et al. DNA Sequencing to Detect Residual Disease in Adults with Acute Myeloid Leukemia Prior to Hematopoietic Cell Transplant. JAMA. 2023; 329 (9): 745 (doi: 10.1001/jama.2023.1363). In patients with acute myeloid leukemia (AML) in first remission before undergoing allogeneic hematopoietic cell transplant, new research shows poorer outcomes for individuals with…

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    • A new observational study examined DNA sequencing on pre-transplant blood of adult patients who had received intial #alloHCT during first complete remission for #AML. Read more about the findings and DNA variants: https://t.co/FTr5f7vFoS #Leusm https://t.co/VWJbqZuRo5

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    Wolters Kluwer Health - 11 month(s) ago

    JavaScript Error JavaScript has been disabled on your browser. You must enable it to continue. Here’s how to enable JavaScript in the following browsers: Internet Explorer From the Tools menu, select Options Click the Content tab Select Enable JavaScript Firefox From the Tools…

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    • A monoclonal antibody called JSP191 (briquilimab); low-dose total body #radiation; and fludarabine, a conditioning regimen for #alloHCT, were safe and well-tolerated in patients with acute myeloid #leukemia and #myelodysplastic syndromes. https://t.co/VFmbKmYn18 https://t.co/1Hwvqjoco3